Sialobiology: Chemistry and Biology of Sialic Acids
at the Institute of Biochemistry in Kiel

Prof. Dr. med. Dipl.-Biochem. Roland Schauer † (Emeritus)

Occurrence, analysis, metabolism, molecular biology, function, evolution and pathobiochemistry of sialic acids

Original Publications

Click here to see the full list of Prof. Schauer's original publications (PDF)
354 T. Eckert, M. Jährling-Butkus, H. Louton, M. Burg-Roderfeld, R. Zhang, N. Zhang, K. Hesse, A. K. Petridis, T. Kožár, J. Steinmeyer, R. Schauer, P. Engelhard, A. Kozarova, J. W. Hudson and HC Siebert
Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms
Mar. Drugs 2021, 19, 542.
353 R. Zhang, L. Jin, N. Zhang, A.K. Petridis, T. Eckert, G. Scheiner-Bobis, M. Bergmann, A. Scheidig, R. Schauer, M. Yan, S.A. Wijesundera, B. Nordén, B.K. Chatterjee, and H.-C. Siebert.
The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools
Mar. Drugs 2019, 17, 469 (1-24).
352 R. Zhang, N. Zhang, M. Mohri, L. Wu, T. Eckert, V.B. Krylov, A. Antosova, S. Ponikova, Z. Bednarikova, P. Markart, A. Günther, B. Nordén, M. Billeter, R. Schauer, A.J. Scheidig, B.N. Ratha, A. Bhunia, K. Hesse, M.A. Enani, J. Steinmeyer, A.K. Petridis, T. Kozar, Z. Gazova, N.E. Nifantiev, and H.-C. Siebert
Nanomedical Relevance of the Intermolecular Interaction Dynamics – Examples from Lysozymes and Insulins
ACS Omega 2019, 4, 4206–4220.
351 R. Zhang, L. Wu, T. Eckert, M. Burg-Roderfeld, M.A. Rojas-Macias, T. Lütteke, V.B. Krylov, D.A. Argunov, A. Datta, P. Markart, A. Guenther, B. Nordén, R. Schauer, A. Bhunia, M.A. Enani, M. Billeter, A.J. Scheidig, N.E. Nifantiev, and H.-C. Siebert
Lysozyme's Lectin-Like Characteristics Facilitates Its Immune Defense Function.
Quart. Rev. Biophys. 2017, 50, e9, 1-12.
350 Zhang R, Loers G, Schachner M, Boelens R, Wienk H, Siebert S, Eckert T, Kraan S, Rojas-Macias MA, Lütteke T, Galuska SP, Scheidig A, Petridis AK, Liang S, Billeter M, Schauer R, Steinmeyer J, Schröder JM, Siebert HC.
Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides.
ChemMedChem 990-1002 (2016)
349 Zhang R, Eckert T, Lutteke T, Hanstein S, Scheidig A, Bonvin AM, Nifantiev NE, Kozar T, Schauer R, Enani MA, Siebert HC.
Structure-Function Relationships of Antimicrobial Peptides and Proteins with Respect to Contact Molecules on Pathogen Surfaces.
Curr Top Med Chem 2016 16(1):89-98
348 F. Orizio, E. Damiati, E. Giacopuzzi, G. Benaglia, S. Pianta, R. Schauer, R. Schwartz-Albiez, G. Borsani, R. Bresciani, and E. Monti
Glycan Metabolism – Human Sialic Acid Acetyl Esterase: Towards a Better Understanding of a Puzzling Enzyme
Glycobiology 2015, 25, 992–1006
347 V.S. Gnanapragassam, K. Bork, C.E. Galuska, S.P. Galuska, D. Glanz, M. Nagasundaram, M. Bache, D. Vordermark, G. Kohla, C. Kannicht, R. Schauer, and R. Horstkorte
Sialic Acid Metabolic Engineering: A Potential Strategy for the Neuroblastoma Therapy.
PLoS ONE 2014, 9, e105403 (1–10).
346 C. Mandal, C. Mandal, S. Chandra, R. Schauer, and C. Mandal
Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia.
Glycobiology 2012 22:70-83 ()
345 D. Wipfler, G. Vinayaga Srinivasan, H. Sadick, B. Kniep, S. Arming, M. Willhauck-Fleckenstein, R. Vlasak, R. Schauer, and R. Schwartz-Albiez
Differentially regulated expression of 9-O-acetyl GD3 (CD60b) and 7-O-acetyl-GD3 (CD60c) during differentiation and maturation of human T and B lymphocytes.
Glycobiology 2011 21:1161-1172
344 S. Arming, D. Wipfler, J. Mayr, A. Merling, U. Vilas, R. Schauer, R. Schwartz-Albiez, and R. Vlasak
The human Cas1 protein: A sialic-acid-specific O-acetyltransferase?
Glycobiology 2011 21:553-564
343 H.-C. Siebert, S.-Y. Lu, R. Wechselberger, K. Born, T. Eckert, S. Liang, C.-W. von der Lieth, J. Jiménez-Barbero, R. Schauer, J.F.G. Vliegenthart, T. Lütteke and T. Kočár
A Lectin from the Chinese Bird-Hunting Spider Binds Sialic Acids.
Carbohydr. Res. 2009 344:1515-1525
Special issue in honor of the 65th birthday of Professor Dr. Hans Kamerling.
342 R. Schauer, G.V. Srinivasan, B. Coddeville, J.-P. Zanetta, and Y. Guérardel
Low Incidence of N-Glycolylneuraminic Acid in Birds and Reptiles and Its Absence in the Platypus
Carbohydr. Res. 2009, 344, 1494–1500.
Special issue in honor of the 65th birthday of Professor Dr. Hans Kamerling.


Click here to see the full list of Prof. Schauer's reviews (PDF).
95 R. Schauer, Johannis P. Kamerling
Chapter One - Exploration of the Sialic Acid World
Adv. Carbohydr. Chem. Biochem. 2018, 75, 1–213.
Dedicated to Prof. Dr. Hans-Dieter Klenk on the occasion of his 80th birthday.
94 A. Varki, R.L. Schnaar, and R. Schauer
Sialic Acids and Other Nonulosonic Acids
Essentials of Glycobiology; A. Varki, R.D. Cummings, J.D. Esko, P. Stanley, G.W. Hart, M. Aebi, A. Darvill, T. Kinoshita, N.H. Packer, J.J. Prestegard, R.L. Schnaar, and P.H. Seeberger, Eds.; 3rd ed.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, USA, 2017; pp 179–195
93 R. Schauer
Entwicklung der Biochemie und Biophysik an der Universität zu Kiel
BIOspektrum 2016, 22, 430–432.
92 Schauer R.
Sialic acids as link to Japanese scientists.
Proc Jpn Acad Ser B 2016, Phys Biol Sci
91 J.A. Cabezas Fernández del Campo, M.T. Miras-Portugal, B. Ribas Ozonas, R. Schauer
Spanisch-deutsche Zusammenarbeit in der Biochemie – drei Lebensläufe
BIOspektrum 2016, 22:107-108
90 H.-C. Siebert, R. Zhang, A. Scheidig, T. Eckert, H. Wienk, R. Boelens, M. Mahvash, A.K. Petridis, and R. Schauer
Interaction Studies of Sialic Acids with Model ReceptorsContribute to Nanomedical Therapies.
J. Neurol. Disord. 2015, 3, 212 (1-6).
89 S. Siebert, P. Engelhard, S. Kraan, R. Schauer und H.-C. Siebert
Gibt es die Apotheke aus dem Meer?
PdN – Biologie in der Schule 2014, 63:39-42
88 E. Giacopuzzi, R. Bresciani, R. Schauer, E. Monti and G. Borsani
New Insights on the Sialidase Protein Family Revealed by a Phylogenetic Analysis in Metazoa.
PLOS ONE 2012, 7(8):e44193, 1-17
87 R. Schauer and J.P. Kamerling
The Chemistry and Biology of Trypanosomal trans-Sialidases: Virulence Factors in Chagas Disease and Sleeping Sickness.
ChemBioChem 2011, 12:2246-2264
86 R. Schauer, G.V. Srinivasan, D. Wipfler, B. Kniep and R. Schwartz-Albiez
O-Acetylated Sialic Acids and their Role in Immune Defense.
In: The Molecular Immunology of Complex Carbohydrates-3; A.M. Wu, Ed.; Adv. Exp. Med. Biol., Vol. 705;
Springer, New York, USA, 2011; pp 525–548.
85 E. Monti, E. Bonten, A. D'Azzo, R. Bresciani, B. Venerando, G. Borsani, R. Schauer and G. Tettamanti
Sialidases in Vertebrates: A Family of Enzymes Tailored for Several Cell Functions.
Adv. Carbohydr. Chem. Biochem. 2010, 64:403-479
84 R. Schauer
Sialic Acids
Remarks upon Receiving the 2009 Rosalind Kornfeld Award for Lifetime Achievement in Glycobiology.
Meeting of the Society for Glycobiology, San Diego, November 12-15, 2009.
83 R. Schauer
Sialic Acids as Regulators of Molecular and Cellular Interactions
Curr. Opin. Struct. Biol. 2009, 19, 507–514.
82 A. Varki and R. Schauer
Sialic Acids
In: Essentials of Glycobiology;
A. Varki, R.D. Cummings, J.D. Esko, H.H. Freeze, P. Stanley, C.R. Bertozzi, G.W. Hart, and M.E. Etzler, Eds.
2nd ed.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, USA, 2009; pp 199–217.
81 R. Schauer
The Diversity of Sialic Acids and Their Interplay with Lectins.
In: Glycobiology; C. Sansom, and O. Markman, Eds.; Scion Publishing Ltd.: Bloxham, UK, 2007; pp 136–149.
80 S. Schrader and R. Schauer
Nonradioactive Trans-Sialidase Screening Assay.
In: Glycobiology Protocols; I. Brockhausen, Ed.; Methods Mol. Biol., Vol. 347; Humana Press Inc.: Totowa, USA, 2006; pp 93–107.


2 Essentials of Glycobiology, 2nd edition
Edited by A. Varki, R.D. Cummings, J.D. Esko, H.H. Freeze, P. Stanley, C.R. Bertozzi, G.W. Hart, M.E. Etzler
Cold Spring Harbor Laboratory Press, Woodbury, pp. 197-217 (2009)
Chapter 14: Sialic Acids, Ajit Varki and Roland Schauer
Go to Chapter Index
Go to Chapter 14
1 Sialic Acids - Chemistry, Metabolism and Function, ed. by R. Schauer (1982)
Cell Biology Monographs, Springer-Verlag Wien New York


  Hans Faillard (1924-2005)
[pdf, German]
  Abraham Rosenberg (1924-2006)

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Last change: 20-Okt-2021