Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

The General Assembly of the CRC877 at its meetings in 2020 and 2021 voted unanimously to reject the unscientific statements of Karina Reiss and Sucharit Bhakdi on the COVID19 pandemic and the vaccination against SARS-CoV2. Moreover, we unanimously reject the antisemitic statements of Sucharit Bhakdi given in a recent interview and widely published on Twitter.

All proteins undergo proteolysis and the regulation of these processes is a critical issue for cell sig­na­ling and tissue ho­meo­sta­sis. Although proteolysis is required for protein disposal and the re­gu­la­tion of the lifespan of proteins, an addi­tio­nal major function of protein cleavage is the or­ches­tra­tion of many signaling pathways. The functions of proteases are essential in many physiological pro­ces­ses, including development, blood coagulation, and cell death. Dysregulation of proteolytic events is as­so­ci­at­ed with the onset of many diseases and pathophysiologic conditions such as inflammation, neu­ro­de­ge­ne­ra­tion, cancer and infectious diseases.

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