Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
2008-2012 Dissertation at the Johannes Gutenberg University Mainz
2003–2008 Studies of Biology at the Johannes Gutenberg University Mainz
Research Experience
Since 2013 Scientific Assistant at the Anatomical Institute, University of Kiel
2012-2013 Scientific Assistant at the Johannes Gutenberg-University Mainz
List of 5 Selected Publications
1. Schneppenheim J, Scharfenberg F, Lucius R, Becker-Pauly C, Arnold P (2017) Meprin beta and BMP-1 are differentially regulated by CaCl2. Cell Calcium 65: 8-13
2. Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C (2017) Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling. Sci Rep 7: 44053
3. Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M (2016) Characterization of the complex formed by beta-glucocerebrosidase and the lysosomal integral membrane protein type-2. Proc Natl Acad Sci U S A 113: 3791-3796
4. Arnold P, Schmidt F, Prox J, Zunke F, Pietrzik C, Lucius R, Becker-Pauly C (2015) Calcium negatively regulates meprin beta activity and attenuates substrate cleavage. FASEB J 29: 3549-3557
5. Broder C, Arnold P, Vadon-Le Goff S, Konerding MA, Bahr K, Muller S, Overall CM, Bond JS, Koudelka T, Tholey A, Hulmes DJ, Moali C, Becker-Pauly C (2013) Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength. Proc Natl Acad Sci U S A 110: 14219-14224