Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
2011 Habilitation in Biology University of Mainz
2002–2004 Dissertation at the University of Münster
1995–2002 Studies of Biology at the University of Münster
Research Experience
Since 2012 W2 Professor at the Department of Biochemistry at the University of Kiel
2011-2012 W1 Junior-Professor, Department of Biochemistry, University of Kiel
2008 Visiting Scientist, University of British Columbia, Vancouver, Canada
2004–2011 Scientific Assistant, Department of Cell and Matrix Biology, University of Mainz
Awards and Honors
2009 Young Investigator Award at the "International Symposium on Kallikrein-related Peptidases (IKS)" in Munich
2008/09 Poster price (Physiology) at the annual conference of the DZG
2008 Best talk at the conference "Proteases and Inhibitors" in Tiers, Italy
List of 5 Selected Publications
1. Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.
Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C (2017)
Cell Rep 21(8):2090-2103
2. Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.
Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU (2016)
Mol Neurodegener 11:19
3. Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.
Schütte A, Ermund A, Becker-Pauly C, Johansson ME, Rodriguez-Pineiro AM, Bäckhed F, Müller S, Lottaz D, Bond JS, Hansson GC (2014)
Proc Natl Acad Sci U S A 111(34):12396-401
4. Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength.
Broder C, Arnold P, Vadon-Le Goff S, Konerding MA, Bahr K, Müller S, Overall CM, Bond JS, Koudelka T, Tholey A, Hulmes DJ, Moali C, Becker-Pauly C (2013)
Proc Natl Acad Sci U S A 110(35):14219-24
5. Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane.
Arolas JL, Broder C, Jefferson T, Guevara T, Sterchi EE, Bode W, Stöcker W, Becker-Pauly C, Gomis-Rüth FX (2012)
Proc Natl Acad Sci U S A 109(40):16131-6