Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
1990 Habilitation in Biochemistry, University of Göttingen
1980 Dissertation, University of Leipzig
1971–1975 Studies of Biochemistry, University of Leipzig
Research Experience
Since 2017 Coordinator of the Research Group (FOR2625): Mechanisms of lysosomal homeostasis
Since 2016 Coordinator of the BMBF Network on Rare Diseases (NCL2TREAT): A network for coordinated research and development of clinical biomarkers, diagnostics, pathomechanisms and therapeutic strategies for neuronal ceroid lipofuscinoses
2008–2017 Coordinator of the Research Training Group (GRK) 1459: Sorting and Protein Interactions in Subcellular Compartments
Since 1999 C3 Professor for Molecular Biology, Department of Biochemistry, Children´s Hospital, University Medical Center Hamburg-Eppendorf
1991-1998 Associate Professor and Group Leader, Institute of Biochemistry, University of Göttingen
1987-1999 Scientific Assistant, Institute of Biochemistry, University of Göttingen
1984-1987 Scientific Assistant, Institute of Physiological Chemistry, University of Münster
1980-1984 Research Associate, Institute of Brain Research, University of Leipzig
List of 5 Selected Publications
1. Otomo T, Schweizer M, Kollmann K, Schumacher V, Muschol N, Tolosa E, Mittrücker HW, Braulke T (2015) Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions. J Cell Biol 208: 171-180
2. Kollmann K, Damme M, Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Kakela R, Walkley SU, Braulke T (2012) Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice. Brain 135: 2661-2675
3. Marschner K, Kollmann K, Schweizer M, Braulke T, Pohl S (2011) A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. Science 333: 87-90
4. Tiede S, Storch S, Lübke T, Henrissat B, Bargal R, Raas-Rothschild A, Braulke T (2005) Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase. Nat Med 11: 1109-1112
5. Braulke T, Tippmer S, Neher E, von Figura K (1989) Regulation of mannose 6-phosphate /IGFII receptor expression at the cell surface by mannose 6-phosphate, insulin-like growth factors and epidermal growth factor. EMBO J 8: 681-686