Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
2004 Habilitation in Neuropathology, University of Zurich
1995-1997 Dissertation at the University of Ulm
1990–1997 Studies of Medicine at the Universities of Ulm, Freiburg and Durban, South Africa
Research Experience
Since 2011 Chairman, Center of Diagnostics, University Medical Center Hamburg Eppendorf
Since 2006 W3 Professor and Director of the Institute of Neuropathology, University Medical Center Hamburg Eppendorf
2002-2006 Co-Director of the Swiss National Reference Center for Prion Diseases
2002-2006 Consultant of Neuropathology, University of Zurich
2000-2002 Residency in Pathology/Neuropathology, University of Zurich
1997-2000 Research Associate, University of Zurich
Awards and Honors
2007 Cavanagh Price of the British Neuropathological Society
2004 Georg-Friedrich-Götz-Award of the University of Zurich
2003 Pfizer Award for Neuroscience
List of 5 Selected Publications
1. Sepulveda-Falla D, Barrera-Ocampo A, Hagel C, Korwitz A, Vinueza-Veloz MF, Zhou K, Schonewille M, Zhou H, Velazquez-Perez L, Rodriguez-Labrada R, Villegas A, Ferrer I, Lopera F, Langer T, De Zeeuw CI, Glatzel M (2014) Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. J Clin Invest 124: 1552-1567
2. Dohler F, Sepulveda-Falla D, Krasemann S, Altmeppen H, Schlüter H, Hildebrand D, Zerr I, Matschke J, Glatzel M (2014) High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease. Brain 137: 873-86
3. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM (2013) CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature 28;495(7442): 474-80
4. Glatzel M, Abela E, Maissen M, Aguzzi A (2003) Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease. N Engl J Med 349: 1812-1820
5. Glatzel M, Heppner FL, Albers KM, Aguzzi A (2001) Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron 31: 25-34