Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
1995-1998 Dissertation at the University of Bonn (summa cum laude)
1989-1995 Studies of Biology at the University of Bonn
Research Experience
Since 2003 C3 Professor for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University Mainz
2001-2003 Assistant Project Scientist, School of Medicine, University California San Diego
1998-2001 Postdoctoral Fellow, School of Medicine, University of California San Diego
List of 5 Selected Publications
1. Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU. (2016) Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier. J Clin Invest 126: 123-136
2. Meister S, Storck SE, Hameister E, Behl C, Weggen S, Clement AM, Pietrzik CU. (2015) Expression of the ALS-causing variant hSOD1(G93A) leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model. J Cereb Blood Flow Metab 35: 1112-1121
3. Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, Pietrzik CU. (2013) LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Mol Neurodegener 8: 25
4. Pietrzik CU, Busse T, Merriam DE, Weggen S and Edward H Koo (2002) The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in amyloid precursor protein processing. EMBO J 21: 5691-5700
5. Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE and EH Koo (2001) A subset of NSAIDs lower amyloidogenic Aβ42 independent of COX activity. Nature 414: 212-216