Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and academic positions
2008 Board Qualification as Specialist in Clinical Chemistry/Laboratory Medicine, Bavarian "Landesärztekammer", Munich
2007 Docent Degree ("Habilitation") in Clinical Biochemistry, University of Würzburg
2006 MD thesis (Dr. med.), supervisor: Prof. U. Walter, University of Würzburg
1996-1999 PhD thesis (Dr. rer. nat.), supervisor: Prof. W. Müller-Esterl, University of Mainz
1992-1993 Research fellowship, Bioorganic Chemistry (Prof. Ogoshi), Kyoto University, Japan
1990-1995 Chemistry, Diploma (Master equivalent), University of Mainz
1989-2001 Medical school, University of Mainz
Research Experience
Since 2013 W3 Professor of Clinical Chemistry, Director of the Institute, University Hospital Eppendorf, Hamburg
2008-2017 Professor of Clinical Chemistry and Coagulation, Karolinska Institute and University Hospital, Stockholm, Sweden
2008 Senior physician in Clinical Chemistry/Coagulation, University Hospital Würzburg
2007 Assistant Professor of Clinical Biochemistry, University of Würzburg
2002-2007 Residency in Medicine and Laboratory Medicine, University Hospital Würzburg
2002-2007 Junior group leader in the DFG-funded SFB355 and 655, University Würzburg
2001-2002 Postdoctoral Fellow, Mentor: Prof. D. Gailani, Vanderbilt University, TN, USA
2000-2001 Postdoctoral Fellow, Mentor: Prof. W. Müller-Esterl, University of Frankfurt
Awards and Honors
2013 Investigator Recognition Award, International Society on Thrombosis and Hemostasis (ISTH)
2011 Theodor Naegeli Award, Basel, Switzerland
2007 Alexander Schmidt Award and Lecture of the Society for Thrombosis and Hemostasis research, GTH
2004-2015 Chair and Co-chair of the SSC subcommittee of the ISTH on Factor XI and the plasma contact system
2005 Gábor-Szász Award of the German Society for Clinical Chemistry and Laboratory
List of 5 Selected Publications
1. Björkqvist J, de Maat S, Lewandrowski U, Di Gennaro A, Oschatz C, Schönig K, Nöthen, MM, Drouet C, Braley H, Nolte MW, Sickmann A, Panousis C, Maas C, Renné T. (2015) Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III. J Clin Invest 25: 3132-3146.
2. Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash, AD, Panousis C, Renné T. (2014) A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk. Science Transl Med 6: 222ra17
3. Oschatz C, Maas C, Lecher B, Jansen T, Björquist J, Tradler T, Sedlmeier R, Burfeind P, Cichon, S, Hammerschmidt S, Müller-Esterl W, Wuillemin WA, Nielsson G, Renné T (2011) Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. Immunity 34: 258-268
4. Müller F, Mutch NJ, Schenk WA, Smith SA, Esterl L, Spronk HM, Schmidbauer S, Gahl WA, Morrissey JH, Renné T (2009) Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 139: 1143-1156
5. Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer U, Renné C, Gailani D, Nieswandt B, Renné T (2006) Targeting coagulation Factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med 203: 513-518