Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
1992 Habilitation in Biochemistry, RWTH Aachen
1979–1982 Dissertation at the University of Heidelberg
1973–1979 Studies of Biology (Chemistry, Physics) at the University of Heidelberg
Research Experience
Since 2000 C4 Professor and Executive Director of the Department of Biochemistry at the University of Kiel
1994–2000 C3 Professor for Pathophysiology, I. Medical Clinic, University of Mainz
1988–1994 Scientific Assistant, Department of Biochemistry, RWTH Aachen
1985–1988 Scientific Assistant, Department of Biochemistry, DKFZ, Heidelberg
1983–1984 Research Associate, Michigan State University, USA
Awards and Honors
2014 Elected Member of the Hamburg Academy of Sciences
2011 Re-elected Member of the DFG Study Section "Biochemistry, Biophysics, Structural Biology and Bioinformatics"
2008 Elected Member of the DFG Study Section "Biochemistry, Biophysics, Structural Biology and Bioinformatics"
2006 Elected Member of the ScanBalt Academy
2005 Science Award of the City Council of Kiel
2004 Boltzmann Award for International Collaboration in Cytokine Research
List of 5 Selected Publications
1. Rose-John S, Winthrop K, Calabrese L (2017) The role of IL-6 in host defense against infections: Immunobiology and Clinical Implications. Nat Rev Rheumatol 13: 399-409
2. Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du X-J, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA (2015) Blocking IL-6 trans-signaling prevents high fat diet-induced adipose tissue macrophage recruitment but does not exacerbate weight gain, liver steatosis or insulin resistance. Cell Metabol 21: 403-416
3. Scheller J, Chalaris A, Garbers C, Rose-John S (2011) ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 32: 380-387
4. Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S (2010) Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med 207: 1617-1624
5. Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, Schutz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schurmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF (2000) Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 6: 583-588