Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
2000 Habilitation in Biochemistry, University of Göttingen
1991-1994 Dissertation at the University of Göttingen, advisor: Prof. K. von Figura
1984-1990 Studies of Biology at the Universities of Bonn and East Anglia, Norwich (Great Britain)
Research Experience
Since 2001 C3 Professor and Director of the Department of Biochemistry at the University of Kiel
1994-2000 Research Associate, University of Göttingen; Biochemie I
Awards and Honors
2010 Hans & Ilse Breuer Alzheimer Award 2011
2002 Selected Finalist of the European Union Descartes Prize
List of 5 Selected Publications
1. Neculai D, Schwake M, Ravichandran M, Zunke F, Collins R, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JP, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S (2013) Structure of LIMP-2/LGP85 provides functional insights; implications for SR-BI and CD36. Nature, in press
2. Reczek D, Schwake M, Schroder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P (2007) LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Cell 131: 770-783
3. Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C (2006) Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314: 664-666
4. Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lullmann-Rauch R, Janssen PM, Blanz J, von Figura K, Saftig P (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406: 902-906
5. De Strooper B*, Saftig P*, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391: 387-390