Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
2007 Habilitation, Charité-Universitätsmedizin Berlin
1997 PhD, University of Cologne
1992-1997 PhD student, Institute of Genetics, University of Cologne
1985-1992 Chemistry, University of Freiburg and Cologne
Research Experience
Since 2018 Director, Institute of Immunology, University of Kiel
2012-2018 University Professor (W2) Charité-Universitätsmedizin Berlin, Clinics for Rheumatology and Clinical Immunology, Cellular Immunology Group
2008-2011 Group Leader, T cell Immunology at Miltenyi Biotec, R&D Department
1997-2011 Head of the research group „Immunomodulation“ at the DRFZ Berlin and head of the Flow-Cytometry Core Facility of DRFZ, MPI for Infection Biology and Charité (2001-2007)
List of 5 Selected Publications
1. Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango MG, Kaufmann S, Röhmel J, Eschenhagen P, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A. (2019) Instruction of human anti-fungal Th17 immunity and immune pathology by cross-reactivity against a single member of the microbiota. Cell 176(6):1340-1355
2. Neumann C, Blume J, Roy U, Teh P,, Vasanthakumar A, Beller A, Liao Y, Heinrich F, Arenzana TL, Hackney JA, Eidenschenk C, Gálvez EJC, Stehle C, Heinz  GA, Maschmeyer P, Sidwell T, Hu Y, Amsen D, Romagnani C, Chang HD, Kruglov A, Mashreghi MF, Shi W, Strowig T, Rutz S*, Kallies A*, Scheffold A*. * (shared authorship) (2019) c-Maf-dependent regulatory T cell control of intestinal Th17 cells and immunoglobulin A establishes host-microbiota homeostasis. Nat. Immunol. 20(4):471-481.
3. Bacher P, Heinrich F, Stervbo U, Nienen N, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A. (2016). Regulatory T cell specificity directs tolerance versus allergy against aeroantigens in humans. Cell. 167(4):1067-1078
4. Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A. (2014). Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med. 211(9):1807-19.
5. Rutz S, Janke M, Kassner N, Hohnstein T, Krueger M, Scheffold A. (2008). Notch regulates IL-10 production by T helper 1 cells. Proc Natl Acad Sci USA. 105(9):3497-502.