Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
2015 Docent degree (Habilitation) in Biochemistry, University of Kiel
2005-2007 Ph.D. (Dr. rer. physiol.) at the Institute of Physiological Chemistry, Philipps-University Marburg
2004 Memorial University of Newfoundland, St. John's, Canada
Clinical elective in Paediatrics
2001-2002 Imperial College School of Medicine, London, UK
Exchange student
1997-2004 Studies of Human Medicine, Philipps-University Marburg and Imperial College School of Medicine, London
Research Experience
Since 04/2018 W2 Professor for Physiological Chemistry and Molecular Biology at the Institute of Physiological Chemistry, Technical University of Dresden, Germany
2007-2018 Scientist and group leader, Biochemical Institute, University of Kiel
Awards and Honors
Since 2012 Member in the Cluster of Excellence "Inflammation at Interfaces
Since 2010 Member in the Collaborative Research Centre (SFB877)
"Proteolysis as a Regulatory Event in Pathophysiology"
2001-2002 Scholarship: Deutscher Akademischer Austauschdienst (DAAD)
1997-2004 Scholarship: Studienstiftung des deutschen Volkes
List of 5 Selected Publications
1. Mentrup T, Häsler R, Fluhrer R, Saftig P, Schröder B (2015) A cell-based assay reveals nuclear translocation of intracellular domains released by SPPL proteases. Traffic 16: 871-892
2. Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass, C, Fluhrer R (2014) Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J 33: 2809-2905
3. Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B (2014) The intramembrane proteases Signal-peptide-peptidase-like 2a/b have distinct functions in vivo. Mol Cell Biol 34: 1398-1411
4. Schneppenheim J, Dressel R, Hüttl S, Lüllmann-Rauch R, Engelke M, Dittmann K, Wienands J, Eskelinen EL, Hermans-Borgmeyer I, Fluhrer R, Saftig P, Schröder B (2013) The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. J Exp Med 210: 41-58
5. Schröder B, Wrocklage C, Pan C, Jäger R, Kösters B, Schäfer H, Elsässer HP, Mann M, Hasilik A (2007) Integral and associated lysosomal membrane proteins. Traffic 8: 1676-1686