Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Third Funding Period (2018-2022)

We analyze in molecular detail extracellular, intramembrane and intracellular proteolytic reactions, which are integral steps of various signaling processes. Examples of extracellular proteolytic events (Research Area A) are the cleavage of cytokines and cytokine receptors, cell adhesion molecules and extracellular matrix proteins, postsynaptic proteins, growth factors and their cognate receptors by various membrane proteases, such as ADAM and meprin metalloproteases, and the importance of these events in development, modulation of the immune system and cancer. Furthermore, we study the involvement of intramembrane and intracellular proteolysis (Research Area B) in apoptotic and caspase-independent cell death, in lysosomal function, in the regulation of epithelial barrier function and in autophagy in the context of inflammatory bowel disease.