Publications of Research Area A1
Analysis of the role to role of the shedding protease ADAM17 in vivo
Teilprojektleiter: Athena Chalaris / Stefan Rose-John
- The interleukin 6 pathway and atherosclerosis.Scheller J, Rose-John S. Lancet. 2012 Jul 28;380(9839):338.
- The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J. FEBS Lett. 2012 Apr 24;586(8):1093-100.
- Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, Rose-John S, Scheller J, Thiery J, Kratzsch J. PLoS One. 2012;7(4):e34787.
- A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S. Biochem J. 2012 Jul 1;445(1):135-44.
- Therapeutic blockade of interleukin-6 in chronic inflammatory disease.Yamamoto K, Rose-John S. Clin Pharmacol Ther. 2012 Apr;91(4):574-6.
- The pro- and anti-inflammatory properties of the cytokine interleukin-6.Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S.Biochim Biophys Acta. 2011 May;1813(5):878-88
- Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model.Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH. Crit Care Med. 2011 Jun;39(6):1407-13.
- Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J. J Biol Chem. 2011 Apr 29;286(17):14804-11.
- Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H. Cancer Cell. 2011 Apr 12;19(4):456-69.
- Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P, Rose-John S, Neurath MF, Geissler EK, Schlitt HJ, Strober W, Fichtner-Feigl S. J Clin Invest. 2011 May;121(5):1692-708.
- ADAM17: a molecular switch to control inflammation and tissue regeneration.Scheller J, Chalaris A, Garbers C, Rose-John S.Trends Immunol. 2011 Aug;32(8):380-7.
- Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.Jones SA, Scheller J, Rose-John S. J Clin Invest. 2011 Sep;121(9):3375-83.
- IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS. J Clin Invest. 2011 Oct;121(10):3846-59.
- Statins potently reduce the cytokine-mediated IL-6 release in SMC / MNC cocultures.Loppnow H, Zhang L, Buerke M, Lautenschläger M, Chen L, Frister A, Schlitt A, Luther T, Song N, Hofmann B, Rose-John S, Silber RE, Müller-Werdan U, Werdan K. J J Cell Mol Med. 2011 Apr;15(4):994-1004
- IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ. J Immunol. 2011 Jan 15;186(2):1199-208
- IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer.Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, Chang JS, Lai TC, Rose-John S, Kuo ML, Wei LH. Cancer Res. 2011 Jan 15;71(2):424-34
- Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis.Loppnow H, Buerke M, Werdan K, Rose-John S. J J Cell Mol Med. 2011 Mar;15(3):484-500
- Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.McGreal EP, Davies PL, Powell W, Rose-John S, Spiller OB, Doull I, Jones SA, Kotecha S. Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58
- ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J.Biochim Biophys Acta. 2010 Feb;1803(2):234-45.
- TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell HW, Rose-John S, Engert A, von Strandmann EP, Hansen HP.Leukemia. 2010 Jan;24(1):51-7.
- Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T. J Immunol. 2010 Feb 1;184(3):1543-51
- Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA. J Immunol. 2010 Feb 15;184(4):2130-9
- Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.McGreal EP, Davies PL, Powell W, Rose-John S, Spiller OB, Doull I, Jones SA, Kotecha S. Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58
- Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6.Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R. J Leukoc Biol. 2010 Sep;88(3):579-87
- Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R. Immunology. 2010 Nov;131(3):395-404
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S. J Exp Med. 2010 Aug 2;207(8):1617-24
- Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B. Blood. 2010 Oct 28;116(17):3347-55
- A role for IL-27p28 as an antagonist of gp130-mediated signaling.Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA. Nat Immunol. 2010 Dec;11(12):1119-26
- VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF. J Exp Med. 2010 Dec 20;207(13):2855-68
