Publications of Research Area A1
Analysis of the role to role of the shedding protease ADAM17 in vivo
Teilprojektleiter: Athena Chalaris / Stefan Rose-John
- IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H. J Clin Invest. 2013, in press
- ADAM17, shedding, TACE as therapeutic targets.Rose-John S. Pharmacol Res. 2013 Feb 12, in press
- The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B. J Thromb Haemost. 2012 Dec;10(12):2581-92
- ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.Trad A, Hansen HP, Shomali M, Peipp M, Klausz K, Hedemann N, Yamamoto K, Mauermann A, Desel C, Lorenzen I, Lemke H, Rose-John S, Grötzinger J. Cancer Immunol Immunother. 2012 Sep 1. [Epub ahead of print]
- The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C. Cell Mol Life Sci. 2013 Jan;70(2):309-33
- A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S. Biochem J. 2012 Jul 1;445(1):135-44.
- Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, Rose-John S, Scheller J, Thiery J, Kratzsch J. PLoS One. 2012;7(4):e34787.
- The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J. FEBS Lett. 2012 Apr 24;586(8):1093-100.
- Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):281-90
- IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS. J Clin Invest. 2011 Oct;121(10):3846-59.
- Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.Jones SA, Scheller J, Rose-John S. J Clin Invest. 2011 Sep;121(9):3375-83
- ADAM17: a molecular switch to control inflammation and tissue regeneration.Scheller J, Chalaris A, Garbers C, Rose-John S. Trends Immunol. 2011 Aug;32(8):380-7
- The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J. Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94
- Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J. J Biol Chem. 2011 Apr 29;286(17):14804-11.
- Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H. Cancer Cell. 2011 Apr 12;19(4):456-69.
- Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B. Blood. 2010 Oct 28;116(17):3347-55
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S. J Exp Med. 2010 Aug 2;207(8):1617-24
- Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.McGreal EP, Davies PL, Powell W, Rose-John S, Spiller OB, Doull I, Jones SA, Kotecha S. Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58
- ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J.Biochim Biophys Acta. 2010 Feb;1803(2):234-45.
- Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA. J Immunol. 2010 Feb 15;184(4):2130-9
- TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell HW, Rose-John S, Engert A, von Strandmann EP, Hansen HP.Leukemia. 2010 Jan;24(1):51-7.
