Publications of Research Area A2
Mechanisms of ADAM17 activation in the context of IL-6R biology
Teilprojektleiter: Jürgen Scheller
- Modalities of Experimental TNF Blockade In Vivo: Mouse Models. Kruglov AA, Tumanov AV, Grivennikov SI, Shebzukhov YV, Kuchmiy AA, Efimov GA, Drutskaya MS, Scheller J, Kuprash DV, Nedospasov SA. Adv Exp Med Biol. 2011;691:421-31
- Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization. Suthaus J, Adam N, Grötzinger J, Scheller J, Rose-John S. Eur J Cell Biol. 2011 Jun-Jul;90(6-7):495-504
- The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer. Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J.Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94
- Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B. Blood. 2010 Oct 28;116(17):3347-55
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S. J Exp Med. 2010 Aug 2;207(8):1617-24
- Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R. J Leukoc Biol. 2010 Sep;88(3):579-87
- Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA. J Immunol. 2010 Feb 15;184(4):2130-9
- Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T. J Immunol. 2010 Feb 1;184(3):1543-51
- ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J. Biochim Biophys Acta. 2010 Feb;1803(2):234-45
