Publications of Research Area A3
Analysis of the postnatal and tissue-specific role of the protease
ADAM10
Teilprojektleiter: Paul Saftig
- Activity-dependent proteolytic cleavage of neuroligin-1.Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T. Neuron. 2012 Oct 18;76(2):410-22.
- Ectodomain shedding and ADAMs in development.Weber S, Saftig P. Development. 2012 Oct;139(20):3693-709.
- Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin.Prox J, Rittger A, Saftig P. Exp Brain Res. 2012 Apr;217(3-4):331-41.
- Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T. Mol Cell Biol. 2012 Feb;32(4):774-82.
- Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice.Sina C, Lipinski S, Gavrilova O, Aden K, Rehman A, Till A, Rittger A, Podschun R, Meyer-Hoffert U, Haesler R, Midtling E, Pütsep K, McGuckin MA, Schreiber S, Saftig P, Rosenstiel P. Gut. 2012 Mar 22. [Epub ahead of print]
- Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.Prox J, Willenbrock M, Weber S, Lehmann T, Schmidt-Arras D, Schwanbeck R, Saftig P, Schwake M. Cell Mol Life Sci. 2012 Sep;69(17):2919-32.
- Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X. Nat Immunol. 2012 May 20;13(7):642-50.
- Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.Tharmarajah G, Faas L, Reiss K, Saftig P, Young A, Van Raamsdonk CD. Pigment Cell Melanoma Res. 2012 Sep;25(5):555-565.
- β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, Joussen AM, Boulton ME. EMBO Mol Med. 2012 Sep;4(9):980-91.
- β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current.Huth T, Rittger A, Saftig P, Alzheimer C. Pflugers Arch. 2011 Mar;461(3):355-71.
- Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2.Desmond MJ, Lee D, Fraser SA, Katerelos M, Gleich K, Martinello P, Li YQ, Thomas MC, Michelucci R, Cole AJ, Saftig P, Schwake M, Stapleton D, Berkovic SF, Power DA. Am J Physiol Renal Physiol. 2011 Jun;300(6):F1437-47.
- Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo.Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D, Jorissen E, Petrowitz B, Bartsch U, De Strooper B, Saftig P, Glatzel M. Mol Neurodegener. 2011 May 27;6:36.
- Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.Sulis ML, Saftig P, Ferrando AA. Leukemia. 2011 Oct;25(10):1564-9.
- The effect of cathepsin K deficiency on airway development and TGF-β1 degradation.Zhang D, Leung N, Weber E, Saftig P, Brömme D. Respir Res. 2011 May 31;12:72.
- Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP. Blood. 2011 Jul 28;118(4):1163-74.
- Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jézégou A, Reinheckel T, Hasilik A, Saftig P, Schröder B. Biochem J. 2011 Oct 1;439(1):113-28.
- Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits.Dauth S, Sîrbulescu RF, Jordans S, Rehders M, Avena L, Oswald J, Lerchl A, Saftig P, Brix K. BMC Neurosci. 2011 Jul 27;12:74.
- The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M. J Neurochem. 2011 Oct;119(1):231-9.
- The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.van Niel G, Charrin S, Simoes S, Romao M, Rochin L, Saftig P, Marks MS, Rubinstein E, Raposo G. Dev Cell. 2011 Oct 18;21(4):708-21.
- The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P. Development. 2011 Feb;138(3):495-505
- The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: Novel drug targets with therapeutic potential? Saftig P, Reiss K.Eur J Cell Biol. 2011 Jun-Jul;90(6-7):527-35
- The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, Saftig P. J Neurosci. 2010 Apr 7;30(14):4833-44
- Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST. J Biol Chem. 2010 Jul 23;285(30):22919-26
- Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways. Mendelson K, Swendeman S, Saftig P, Blobel CP. J Biol Chem. 2010 Aug 6;285(32):25024-32
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S. J Exp Med. 2010 Aug 2;207(8):1617-24
- ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP. J Cell Sci. 2010 Nov 15;123(Pt 22):3913-22
