Publications of Research Area A5
Molecular mechanisms and functional consequences of
ADAM protease activation induced by extracellular NAD or ATP
Teilprojektleiter: Friedrich Koch-Nolte
- Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation. Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse AH, Haag F, Adriouch S, Koch-Nolte F. PLoS One. 2012;7(7):e41269
- Extracellular NAD(+): a danger signal hindering regulatory T cells.Adriouch S, Haag F, Boyer O, Seman M, Koch-Nolte F. Microbes Infect. 2012 Nov;14(14):1284-92
- Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrä J, Bhakdi S, Reiss K. J Biol Chem. 2012 Jul 6;287(28):23678-89
- Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P, Schröder B. FEBS Lett. 2011 Oct 3;585(19):2951-7
- Strategies for the identification of arginine ADP-ribosylation sites.Laing S, Koch-Nolte F, Haag F, Buck F. J Proteomics. 2011 Dec 10;75(1):169-76
- Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death.Bannas P, Scheuplein F, Well L, Hermans-Borgmeyer I, Haag F, Koch-Nolte F. Mol Immunol. 2011 Sep;48(15-16):1762-70
- Progress in the function and regulation of ADP-Ribosylation.Hottiger MO, Boothby M, Koch-Nolte F, Lüscher B, Martin NM, Plummer R, Wang ZQ, Ziegler M. Sci Signal. 2011 May 24;4(174):mr5
- Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J. J Biol Chem. 2011 Apr 29;286(17):14804-11
- Compartmentation of NAD+-dependent signalling.Koch-Nolte F, Fischer S, Haag F, Ziegler M. FEBS Lett. 2011 Jun 6;585(11):1651-6
- Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium. Alzogaray V, Danquah W, Aguirre A, Urrutia M, Berguer P, García Véscovi E, Haag F, Koch-Nolte F, Goldbaum FA. FASEB J. 2011 Feb;25(2):526-34
- ADP-ribosylation of arginine. Laing S, Unger M, Koch-Nolte F, Haag F. Amino Acids. 2011 Jul;41(2):257-69
- Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M, Adriouch S. J Exp Med. 2010 Nov 22;207(12):2561-8
- Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells. Bannas P, Graumann O, Balcerak P, Peldschus K, Kaul MG, Hohenberg H, Haag F, Adam G, Ittrich H, Koch-Nolte F. Mol Imaging. 2010 Aug;9(4):211-22
- Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F. Trends Biochem Sci. 2010 Apr;35(4):208-19
- A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV. J Autoimmun. 2010 Mar;34(2):145-54
