Publications of Research Area A6
Structure-function analysis of the
extracellular part of ADAM17
Teilprojektleiter: Joachim Grötzinger
- d(GGGT)4 and r(GGGU)4 are both HIV-1 Inhibitors and Interleukin-6 Receptor Aptamers. Magbanua, E., Zivkovic, T., Hansen, B., Beschorner, N., Meyer, C., Lorenzen, I., Grötzinger, J., Hauber, J., Torda, A.E., Mayer, G., Rose-John, S., Hahn, U. RNA Biology 10, 1-12 (2013)
- Rat Oncostatin M equals human Oncostatin M by signaling via the type I gp130/LIFR as well as the type II gp130/OSMR complex. Drechsler, J., Grötzinger, J., Hermanns, H.M. Plos One 7, e43155 (2012)
- Plasticity and cross-talk of interleukin 6-type cytokines.Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J. Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97.
- The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J. FEBS Lett. 2012 Apr 24;586(8):1093-100.
- A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S. Biochem J. 2012 Jul 1;445(1):135-44.
- Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain.
Lorenzen, I., Trad, A., Grötzinger, J. Biochem Biophys Res Commun 415, 330-336 (2011) - Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17. Trad A, Hedemann N, Shomali M, Pawlak V, Grötzinger J, Lorenzen I. J Immunol Methods. 2011 Aug 31;371(1-2):91-6
- The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution. Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J.Eur J Cell Biol. 2011 Jun-Jul;90(6-7):515-20
- A role for IL-27p28 as an antagonist of gp130-mediated signaling. Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA. Nat Immunol. 2010 Dec;11(12):1119-26
- The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. J Immunol. 2010 Feb 15;184(4):1990-2000
- N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. J Biol Chem. 2010 Jan 15;285(3):1781-9
