Publications of Research Area A6
Structure-function analysis of the
extracellular part of ADAM17
Teilprojektleiter: Joachim Grötzinger.
- The disintegrin domain of ADAM17 antagonises fibroblast-carcinoma cell interactions.
Trad, A., Riese, M., Shomali, M., Hedeman, N. Grötzinger, J., Lorenzen, I.
Int J Oncol 42, 1793-1800 (2013) - An interleukin-6 ±-receptor dependent molecular switch mediates the IL-27 cytokine subunit p28 (IL-30) signal transduction via a gp130 ¾-receptor homodimer.Garbers, C., Spudy, B., Aparicio-Siegmund, S. Waetzig, G.H., Sommer, J., Hölscher, C., Rose-John, S., Grötzinger, J., Lorenzen, I., Scheller, J. J Biol Chem 288, 4346-4354, (2013)
- Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.Smith, K.R., Dahl, H.H., Canafoglia, L., Andermann, A., Damiano, J., Morbin, M., Franceschetti, S., Cossette, P., Saftig, P., Grötzinger, J., Schwake, M., Andermann, F., Staropoli, J.F., Sims,K.B., Mole, S.E., Alexander, N.A. Cooper, J.D.,Chapman, H.A., Carpenter, S., Berkovic, S.F., Bahlo, M. Hum Mol Genet 22, 1417-1423 (2013)
- ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugate. Trad, A., Hansen, H.P., Shomali, M., Peipp, M., Klausz, K., Hedemann, N., Yamamoto, K., Desel, C., Lorenzen, I., Lemke, H., Rose-John, S., Grötzinger, J. Cancer Immunology Immunotherapy 62, 411-421 (2013)
- d(GGGT)4 and r(GGGU)4 are both HIV-1 Inhibitors and Interleukin-6 Receptor Aptamers. Magbanua, E., Zivkovic, T., Hansen, B., Beschorner, N., Meyer, C., Lorenzen, I., Grötzinger, J., Hauber, J., Torda, A.E., Mayer, G., Rose-John, S., Hahn, U. RNA Biology 10, 1-12 (2013)
- Rat Oncostatin M equals human Oncostatin M by signaling via the type I gp130/LIFR as well as the type II gp130/OSMR complex. Drechsler, J., Grötzinger, J., Hermanns, H.M. Plos One 7, e43155 (2012)
- Plasticity and cross-talk of interleukin 6-type cytokines.Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J. Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97.
- The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J. FEBS Lett. 2012 Apr 24;586(8):1093-100.
- A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S. Biochem J. 2012 Jul 1;445(1):135-44.
- Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain.
Lorenzen, I., Trad, A., Grötzinger, J. Biochem Biophys Res Commun 415, 330-336 (2011) - Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17. Trad A, Hedemann N, Shomali M, Pawlak V, Grötzinger J, Lorenzen I. J Immunol Methods. 2011 Aug 31;371(1-2):91-6
- The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution. Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J.Eur J Cell Biol. 2011 Jun-Jul;90(6-7):515-20
- A role for IL-27p28 as an antagonist of gp130-mediated signaling. Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA. Nat Immunol. 2010 Dec;11(12):1119-26
- The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. J Immunol. 2010 Feb 15;184(4):1990-2000
- N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. J Biol Chem. 2010 Jan 15;285(3):1781-9
