Publications of Research Area A9
Function of the metalloproteases meprin α and meprin β in pathophysiology
Teilprojektleiter: Christoph Becker-Pauly
- The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C. Cell Mol Life Sci. 2013 Jan;70(2):309-33.
- Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.Geurts N, Becker-Pauly C, Martens E, Proost P, Van den Steen PE, Stöcker W, Opdenakker G. FEBS Lett. 2012 Dec 14;586(24):4264-9.
- Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane.Arolas JL, Broder C, Jefferson T, Guevara T, Sterchi EE, Bode W, Stöcker W, Becker-Pauly C, Gomis-Rüth FX.Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16131-6.
- Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit BMP-1/tolloid-like proteinases. Bijakowski C, Vadon-Le Goff S, Delolme F, Bourhis JM, Lécorché P, Ruggiero F, Becker-Pauly C, Yiallouros I, Stöcker W, Dive V, Hulmes DJ, Moali C.J Biol Chem. 2012 Sep 28;287(40):33581-93.
- The metalloprotease meprin β generates amino terminal truncated Aβ-peptide species. Bien J, Jefferson T, Causevic M, Jumpertz T, Muenter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU.J Biol Chem. 2012 Sep 28;287(40):33304-13.
- Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. Minder P, Bayha E, Becker-Pauly C, Sterchi EE.J Biol Chem. 2012 Oct 12;287(42):35201-11.
- Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer. Lottaz D, Maurer CA, Noël A, Blacher S, Huguenin M, Nievergelt A, Niggli V, Kern A, Müller S, Seibold F, Friess H, Becker-Pauly C, Stöcker W, Sterchi EE. PLoS One. 2011;6(11):e26450.
- Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. Biniossek ML, Nägler DK, Becker-Pauly C, Schilling O. J Proteome Res. 2011 Dec 2;10(12):5363-73.
- A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, Becker-Pauly C, Ghatei MA, Bloom SR, Murphy KG. Endocrinology. 2011 Dec;152(12):4630-40.
- Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli. Vazeille E, Bringer MA, Gardarin A, Chambon C, Becker-Pauly C, Pender SL, Jakob C, Müller S, Lottaz D, Darfeuille-Michaud A. PLoS One. 2011;6(6):e21199.
- Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Mol Cell Proteomics. 2011 Sep;10(9):M111.009233.
- Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion. Ohler A, Becker-Pauly C. Biol Chem. 2011 Jul;392(7):653-64.
- Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. Jefferson T, Čaušević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. J Biol Chem. 2011 Aug 5;286(31):27741-50.
