Publications of Research Area B3
Proteolysis-mediated regulation of mannose
6-phosphate-dependent transport of lysosomal enzymes
Teilprojektleiter: Sandra Pohl / Thomas Braulke
- Transport of the GlcNAc-1-phosphotransferase α/β-Subunit Precursor Protein to the Golgi Apparatus Requires a Combinatorial Sorting Motif.Franke M, Braulke T, Storch S. J Biol Chem. 2013 Jan 11;288(2):1238-49.
- Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.Kollmann K, Damme M, Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T. Brain. 2012 Sep;135(Pt 9):2661-75.
- Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T. Mol Cell Biol. 2012 Feb;32(4):774-82.
- Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis.Thelen M, Damme M, Schweizer M, Hagel C, Wong AM, Cooper JD, Braulke T, Galliciotti G. PLoS One. 2012;7(4):e35493.
- Residual activity and proteasomal degradation of p.Ser298Pro sulfamidase identified in patients with a mild clinical phenotype of Sanfilippo A syndrome.Muschol N, Pohl S, Meyer A, Gal A, Ullrich K, Braulke T. Am J Med Genet A. 2011 Jul;155A(7):1634-9.
- A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism.Marschner K, Kollmann K, Schweizer M, Braulke T, Pohl S. Science. 2011 Jul 1;333(6038):87-90.
- Post-translational modifications of the gamma-subunit affect intracellular trafficking and complex assembly of GlcNAc-1-phosphotransferase.Encarnacao M, Kollmann K, Trusch M, Braulke T, Pohl S. J J Biol Chem. 2011 Feb 18;286(7):5311-8
- Mannose phosphorylation in health and disease. Kollmann K, Pohl S, Marschner K, Encarnação M, Sakwa I, Tiede S, Poorthuis BJ, Lübke T, Müller-Loennies S, Storch S, Braulke T. Eur J Cell Biol. 2010 Jan;89(1):117-23
- Loss of N-acetylglucosamine-1-phosphotransferase gamma subunit due to intronic mutation in GNPTG causes mucolipidosis type III gamma: Implications for molecular and cellular diagnostics. Pohl S, Encarnacão M, Castrichini M, Müller-Loennies S, Muschol N, Braulke T. Am J Med Genet A. 2010 Jan;152A(1):124-32
- A novel single-chain antibody fragment for detection of mannose 6-phosphate-containing proteins: application in mucolipidosis type II patients and mice. Müller-Loennies S, Galliciotti G, Kollmann K, Glatzel M, Braulke T. Am J Pathol. 2010 Jul;177(1):240-7
- Proteolytic processing of the gamma-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages. Pohl S, Tiede S, Marschner K, Encarnação M, Castrichini M, Kollmann K, Muschol N, Ullrich K, Müller-Loennies S, Braulke T. J Biol Chem. 2010 Jul 30;285(31):23936-44
