Publications of Research Area B9
Genetic variants in protein degradation
pathways: from normal population variability to altered inflammatory
responses in the intestinal tract
Teilprojektleiter: Philip Rosenstiel / Stefan Schreiber
- ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, Penninger JM. Nature. 2012 Jul 25;487(7408):477-81.
- The 1000 Genomes Project: data management and community access. Clarke L, Zheng-Bradley X, Smith R, Kulesha E, Xiao C, Toneva I, Vaughan B, Preuss D, Leinonen R, Shumway M, Sherry S, Flicek P; 1000 Genomes Project Consortium. Nat Methods. 2012 Apr 27;9(5):459-62.
- mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. Derer S, Till A, Haesler R, Sina C, Grabe N, Jung S, Nikolaus S, Kuehbacher T, Groetzinger J, Rose-John S, Rosenstiel PC, Schreiber S. Gut. 2012 Apr 25. [Epub ahead of print]
- Microbial pattern recognition causes distinct functional micro-RNA signatures in primary human monocytes. Häsler R, Jacobs G, Till A, Grabe N, Cordes C, Nikolaus S, Lao K, Schreiber S, Rosenstiel P. PLoS One. 2012;7(2):e31151.
- Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Rausch P, Rehman A, Künzel S, Häsler R, Ott SJ, Schreiber S, Rosenstiel P, Franke A, Baines JF. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19030-5.
- Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH. Crit Care Med. 2011 Jun;39(6):1407-1413
- Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Häsler R, Kerick M, Manke T, Seegert D, Hanidu A, Schäfer H, van Heel D, Li J, Schreiber S, Rosenstiel P. J Immunol. 2011 Apr 1;186(7):4027-38
- IL-1β and ADAM17 are central regulators of β-defensin expression in Candida esophagitis.Pahl R, Brunke G, Steubesand N, Schubert S, Böttner M, Wedel T, Jürgensen C, Hampe J, Schäfer H, Zeissig S, Schreiber S, Rosenstiel P, Reiss K, Arlt A. Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G547-53
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S. J Exp Med. 2010 Aug 2;207(8):1617-24
- SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region. Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A. Hum Mutat. 2010 Jul;31(7):875-85
- Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma. Schulte JH, Marschall T, Martin M, Rosenstiel P, Mestdagh P, Schlierf S, Thor T, Vandesompele J, Eggert A, Schreiber S, Rahmann S, Schramm A. Nucleic Acids Res. 2010 Sep 1;38(17):5919-28
- Both copy number and sequence variations affect expression of human DEFB4. Groth M, Wiegand C, Szafranski K, Huse K, Kramer M, Rosenstiel P, Schreiber S, Norgauer J, Platzer M. Genes Immun. 2010 Sep;11(6):458-66
- Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH; IBSEN study group, Krawczak M, Rosenstiel P, Karlsen TH, Schreiber S. Nat Genet. 2010 Apr;42(4):292-4
- N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. J Biol Chem. 2010 Jan 15;285(3):1781-9
- Screening of human gene promoter activities using transfected-cell arrays. Cheng X, Guerasimova A, Manke T, Rosenstiel P, Haas S, Warnatz HJ, Querfurth R, Nietfeld W, Vanhecke D, Lehrach H, Yaspo ML, Janitz M. Gene. 2010 Jan 15;450(1-2):48-54
- Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB. Sina C, Arlt A, Gavrilova O, Midtling E, Kruse ML, Müerköster SS, Kumar R, Fölsch UR, Schreiber S, Rosenstiel P, Schäfer H. Inflamm Bowel Dis. 2010 Feb;16(2):320-31
