Proteolysis as a Regulatory Event in Pathophysiology

Sonderforschungsbereich 877

An der Christian-Albrechts-Universitšt zu Kiel

First Funding Period


Research Area A

Proteases at the Plasma Membrane: Structure, Function and Mechanisms of Pathophysiology

A1 - Analysis of the role to the shedding protease ADAM17 in vivo
Chalaris / Rose-John (Biochemisches Institut, CAU Kiel)

A2 - Mechanisms of ADAM activation in the context of IL-6/sIL-6R biology
Scheller (Biochemisches Institut, Uni Düsseldorf)

A3 - Analysis of the postnatal and tissue-specific role of the protease ADAM10
Saftig (Biochemisches Institut, CAU Kiel)

A4 - Regulation and functional relevance of ADAM10 and ADAM17-mediated proteolysis
Reiß (Hautklinik CAU Kiel)

A5 - Molecular mechanisms and functional consequences of ADAM protease activation induced by extracellular NAD or ATP
Koch-Nolte (Institut für Immunologie, UKE Hamburg)

A6 - Structure-function analysis of the extracellular part of ADAM17
Grötzinger (Biochemisches Institut, CAU Kiel)

A7 - Mechanisms and implications of NKG2D ligand shedding
Kabelitz (Institut für Immunologie, UKSH Kiel)

A9 - Function of the metalloproteases meprin α and meprin β in pathophysiology
(Biochemisches Institut, CAU Kiel)


Research Area B

Intracellular Proteolysis: From Cell Biology to Disease

B1 - Role of ubiquitinylation and proteolysis in the regulation of pro- and anti-apoptotic TNF-RI signaling
Schütze (Institut für Immunologie, UKSH Kiel)

B2 - Proteolysis in the regulation of caspase-independent programmed cell death
Adam / Schütze (Institut für Immunologie, UKSH Kiel)

B3 - Proteolysis-mediated regulation of mannose 6-phosphate-dependent transport of lysosomal enzymes
Pohl / Braulke (Abteilung Biochemie, Kinderklinik, UKE Hamburg)

B4 - Proteolysis-dependent post-translational modifications in control of the death factor CD95L
Janßen (Institut für Immunologie, CAU Kiel)

B7 - Characterization of the in vivo functions of signal-peptide-peptidase-like 2-a/b (SPPL2-a/b) in mouse models
Saftig (Biochemisches Institut, CAU Kiel)

B8 - Determinants of voltage-gated cation channels as substrates for regulated proteolysis
Schwake (Biochemisches Institut, CAU Kiel)

B9 - Genetic variants in protein degradation pathways: from normal population variability to altered inflammatory responses in the intestinal tract
Rosenstiel / Schreiber (Institut für Klinische Molekularbiologie, UKSH Kiel)


Research Area Z

Central Service Projects

Z2 - Proteomics platform for the analysis of proteolysis-induced protein alterations and modifications
Tholey / Janßen / Leippe (Institut für Experimenelle Medizin, CAU Kiel, Institut für Immunologie CAU Kiel; Zoologisches Institut, CAU Kiel)

Z3 - Microscopy core facility and antibody production: Analysis of protease structure, cell biology and function
Saftig / Grötzinger (Biochemisches Institut, CAU Kiel)


Integrated Research Training Group (IRTG)

Click here for a list of publications of members of the IRTG