Prof. Dr. rer. nat. Dieter Adam
Institut für Immunologie, CAU Kiel
Born 24.11.1961
| 1982–1987 | Studies of Biology at the Ludwig-Maximilians-University, Munich |
| 1988–1990 | Dissertation at the Max-Planck-Institute for Biochemistry, Martinsried |
| 1991 | Post-Doc at the Max-Planck-Institute, Martinsried |
| 1991–1993 | Post-Doc at the Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, USA |
| 1993–1995 | Post-Doc at the Institute for Medical Microbiology and Hygiene, Technical University of Munich |
| Since 1995 | Principal Investigator at the Institute of Immunology, Christian-Albrechts-University, Kiel |
| 1998 | Habilitation and Venia legendi for Immunology |
| Since 2003 | Professor at the Institute of Immunology, Christian-Albrechts-University, Kiel |
10 Selected Publications
- Nguyen, X-H*, Lang, P*, Lang, K*, Adam, D*, Fattakhova, G, Föger, N, Kamal, A, Prilla, P, Mathieu, S, Wagner, C, Mak, T, Chan, AC, Lee, K-H. (2011) Toso regulates the balance between apoptotic and non-apoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood, in press.
*these authors contributed equally to this paper
- Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Schütze S, Adam D. (2010) The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase. Proc Natl Acad Sci U S A. 107: 1112-1117
- von Bismarck P, Wistädt CFG, Klemm K, Winoto-Morbach S, Uhlig U, Schütze S, Adam D, Lachmann B, Uhlig S, Krause MF. (2008) Improved pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model. Am J Resp Crit Care Med 177: 1233-1241
- Egberts JH, Cloosters V, Noack A, Schniewind B, Thon L, Klose S, Kettler B, von Forstner C, Kneitz C, Tepel J, Adam D, Wajant H, Kalthoff H, Trauzold A. (2008) Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 68: 1443-1450
- Möhlig H, Mathieu S, Thon L, Frederiksen MC, Ward DM, Kaplan J, Schütze S, Kabelitz D, Adam D. (2007) The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation/membrane recruitment of protein kinase C. Exp Cell Res 313: 2703- 2718
- Thon L, Mathieu S, Kabelitz D, Adam D. (2006) The murine TRAIL-receptor signals caspaseindependent cell death through ceramide. Exp Cell Res 312: 3808-3821
- Neumeyer J, Hallas C, Merkel O, Winoto-Morbach S, Jakob M, Thon L, Adam D, Schneider- Brachert W, Schütze S. (2006) TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinase. Exp Cell Res 312: 2142-2153
- Thon L, Möhlig H, Mathieu S, Lange A, Bulanova E, Winoto-Morbach S, Schütze S, Bulfone- Paus S, Adam D. (2005) Ceramide mediates caspase-independent programmed cell death. FASEB J 19: 1945-1956
- Lange A, Thon L, Mathieu S, Adam D. (2005) The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor. Biochem Biophys Res Commun 335: 575-583
- Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D, Mentlein R, Kabelitz D, Schütze S. (2004) Compartmentalization of TNF-receptor 1 signaling: internalized TNF-receptosomes as death signaling vesicles. Immunity 21: 415-428
