Prof. Dr. rer. nat. Christoph Becker-Pauly
Biochemisches Institut, CAU Kiel
Born 08.08.1975
| 1995–2002 | Studies of Biology at the University of Münster |
| 2002–2004 | Dissertation at the University of Münster |
| 2004-2007 | Scientific Assistant, University of Mainz |
| 2008 | Visiting Scientist, University of British Columbia, Vancouver, Canada |
| 2007–2011 | Principal Investigator, University of Mainz |
| 2011 | Habilitation in Biology University of Mainz |
| since 2011 | W1 Professor at the Department of Biochemistry at the University of Kiel |
10 Selected Publications
- Jefferson T, auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi EE, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C*. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Cellular and Molecular Life Sciences, in press
- Bien J, Jefferson T, Causevic M, Jumpertz T, Muenter L, Multhaup G, Weggen S, Becker-Pauly C*, Pietrzik CU* (2012). The metalloprotease meprin β generates amino terminal truncated Aβ-peptide species. Journal of Biological Chemistry, doi: 10.1074/jbc.M112.395608
- Arolas JL, Broder C, Jefferson T, Guevera T, Sterchi EE, Bode W, Stöcker W, Becker-Pauly C, Xavier Gomis-Rüth F. Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane. Proc Natl Acad Sci USA, in press
- Minder P, Bayha E, Becker-Pauly, C, Sterchi EE (2012). Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. Journal of Biological Chemistry
- Becker-Pauly C*, Barré O, Schilling O, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, and Overall CM (2011). Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Molecular & Cellular Proteomics, doi: 10.1074/mcp.M111.009233
- Jefferson T, Causevic M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU*, and Becker-Pauly C* (2011). Metalloprotease Meprin β Generates Nontoxic Amyloid Precursor Fragments in Vivo. Journal of Biological Chemistry, 286(31), 27741-50
- Kronenberg D, Bruns BC, Moali C, Vadon-Le Goff S, Sterchi EE, Traupe H, Böhm M, Hulmes DJS, Stöcker W, and Becker-Pauly C* (2010). Processing of procollagen III by meprins: new players in extracellular matrix assembly? Journal of Investigative Dermatology, 130(12), 2727-35
- Hedrich J, Lottaz D, Meyer K, Yiallouros I, Jahnen-Dechent W, Stöcker W, and Becker-Pauly C* (2010). Fetuin-A and Cystatin C are Endogenous Inhibitors of human Meprin Metalloproteases. Biochemistry, 49 (39), 8599–8607
- Ohler A, Debela M, Magdolen V, and Becker-Pauly C* (2010). Meprin Metalloproteases are activated specifically by KLK 4,5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation. Biological Chemistry, 391(4), 455-460
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Schütte A, Hedrich J, Stöcker W, Becker-Pauly C* (2010). Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2. PLoS One, 21;5(1):e8835
* corresponding author
