Prof. Dr. Thomas Braulke
Kinderklinik - Abteilung Biochemie, Universitätsklinikum Hamburg Eppendorf
Born 07.06.1953
| 1971–1975 | Studies of Biochemistry at the University of Leipzig |
| 1980 | Ph.D. thesis |
| 1980–1990 | Post-Doctorate at the University of Leipzig (Dept Neurochemistry, Prof. Biesold); at the Universität Münster (Inst. of Physiol. Chemistry; Prof. K. von Figura), Georg-August-Universität Göttingen (Inst. of Biochemistry II; Prof. K. von Figura) |
| 1990 | Habilitation in Biochemistry |
| 1991–1995 | Privatdozent, University of Göttingen |
| 1995–1998 | Associate Professor and Tenure, Institute of Biochemistry II, University of Göttingen |
| since 1999 | C3-Professor in Hamburg |
10 Selected Publications
- Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T. (2011) Mannose 6-dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. Mol Cell Biol. 2011 Dec 12. [Epub ahead of print]
- Marschner K, Kollmann K, Schweizer M, Braulke T, Pohl S. (2011) A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. Science. 333: 87-90.
- Müller-Loennies S, Galliciotti G, Kollmann K, Glatzel M, Braulke T. A novel single-chain antibody fragment for detection of mannose 6-phosphate-containing proteins: application in mucolipidosis type II patients and mice. Am J Pathol. 2010 Jul;177(1):240-7. Epub 2010 May 14.
- Pohl S, Tiede S, Marschner K, Encarnação M, Castrichini M, Kollmann K, Muschol N, Ullrich K, Müller-Loennies S, Braulke T. (2010) Proteolytic processing of the γ-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages. J Biol Chem. 285: 23936-23944
- Keyser B, Mühlhausen C, Dickmanns A, Christensen E, Muschol N, Ullrich K, Braulke T (2008) Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH). Hum Mol Genet 17: 3854-3863
- Storch S, Pohl S, Quitsch A, Falley K, Braulke T. (2007) C-terminal prenylation of the CLN3 membrane glycoprotein is required for efficient endosoma l sorting to lysosomes. Traffic 8: 431-444
- Tiede S, Cantz M, Spranger J, Braulke T. (2006) Missense mutation in the N-acetylglucosamine-1-phosphotransferase gene (GNPTA) in a patient with mucolipidosis II induces changes in the size and cellular distribution of GNPTG. Hum. Mutat 27: 830-835
- Tiede S, Storch S, Lübke T, Henrissat B, Bargal R, Raas-Rothschild A, Braulke T. (2005) Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase. Nat Med 11: 1109-1112
- Storch S, Pohl S, Braulke T. (2004) A dileucine motif and a cluster of acidic amino acids in the second cytoplasmic domain of the batten disease-related CLN3 protein are required for efficient lysosomal targeting. J Biol Chem 279: 53625-53634
- Scharf JG, Dombrowski F, Novosyadlyy R, Eisenbach C, Demori I, Kübler B, Braulke T. (2004) Insulin-like growth factor binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cells. Endocrinology 145: 3463-3472
