Prof. Dr. rer. biol. hum. Ottmar Janßen
Institut für Immunologie, Molekulare Immunologie, CAU Kiel
Born 23.07.1958
| 1979–1986 | Studies of Biology at University of Ulm |
| 1989 | Doctorate (Dr. rer. biol. hum.), Medical Faculty, University of Ulm |
| 1989–1991 | Postdoctoral Fellow, Institute for Immunology, University of Heidelberg |
| 1992–1994 | Research Fellow and Research Associate, Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA |
| 1994–1999 | Group Leader, Department of Immunology, Paul-Ehrlich-Institute Langen |
| 1999 | Habilitation, Venia legendi Biochemistry, Faculty of Natural Sciences, University of Frankfurt |
| 1999–2006 | Group Leader, Institute for Immunology, University of Kiel |
| 2002 | Venia legendi Molecular Immunology, Faculty of Medicine, University of Kiel |
| since 2006 | Professor for Molecular Immunology, Christian-Albrechts-University of Kiel |
| 2007 | Research award of the Hensel Foundation |
10 Selected Publications
- Biller L, Schmidt H, Krause E, Gelhaus C, Handal G, Lotter H, Janssen O, Tannich E, Bruchhaus I. (2009) Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties. Proteomics published online
- Schmidt H, Gelhaus C, Latendorf T, Nebendahl M , Petersen A, Krause S, Leippe M, Becker W-M, Janssen O. (2009) 2D-DIGE analysis of the proteome of extracts from peanut variants reveals striking differences in major allergen contents. Proteomics 9: 3507-3521
- Paulsen M, Mathew B, Lettau M, Qian J, Kabelitz D, Janssen O. (2009) FasL crosslinking inhibits activation of human peripheral T cells. Int Immunol 21: 587-598
- Lettau M, Paulsen M, Kabelitz D, Janssen O. (2008) Storage, expression and function of Fas ligand, the key death factor of immune cells. Curr Med Chem 15: 1684-1696
- Schmidt H, Gelhaus C, Nebendahl M, Lettau M, Watzl C, Kabelitz D, Leippe M, Janssen O. (2008) 2D-DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells. Proteomics 8: 2911-2925
- Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. (2007) ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death Diff 14: 1040-1049
- Lettau M, Qian J, Linkermann A, Larose L, Latreille M, Kabelitz D, Janssen O. (2006) The adapter protein Nck interacts with FasLigand: Guiding the death factor to the cytotoxic immunological synapse. P Natl Acad Sci (USA) 103: 5911-5916
- Qian J, Chen W, Lettau M, Podda G, Zörnig M, Kabelitz D, Janssen O. (2006) Regulation of FasL expression: A SH3 domain containing protein family involved in the lysosomal association of FasL. Cell Signal 18: 1327-1337
- Linkermann A, Qian J, Lettau M, Kabelitz D, Janssen O. (2005) Considering Fas Ligand as a target for therapy. Expert Opin Ther Tar 9: 119-134
- Baum W, Kirkin V, Mateus Fernández S B, Pick R, Lettau M, Janssen O, Zörnig M. (2005) Binding of the intracellular Fas Ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL. J Biol Chem 280: 40012-40024
