Prof. Dr. med. Friedrich Koch-Nolte
Institut für Immunologie, UKE Hamburg
Born 17. 03. 1957
| 1973–1976 | Studies of Biology, Lehigh and Wesleyan Universities, USA |
| 1976 | Bachelor of Arts in Biology, Wesleyan University |
| 1976–1983 | Study of Medicine, Universities of Hamburg and Tübingen |
| 1983 | MD, University of Tübingen |
| 1984–1986 | Studies of Molecular Biology, University of Hamburg |
| 1986 | Abschlussdiplom Molekularbiologie, University of Hamburg |
| 1986–1997 | Habilitation and venia legendi in Immunology and Molecular Biology, University of Hamburg |
| Since 1997 | Professor of Immunology and Molecular Biology, Deputy Director of the Institute of Immunolgy University Medical Center, Hamburg |
10 Selected Publications
- Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch- Nolte F. (2009) NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells. J Immunol 182: 2898- 2908
- Koch-Nolte F, Haag F, Guse AH, Lund F, Ziegler M. (2009) Emerging roles of NAD+ and its metabolites in cell signaling. Sci Signal 2 (57):mr1. Review
- Schwarz N, Fliegert R, Adriouch S, Seman M, Guse AH, Haag F, Koch-Nolte F. (2009) Activation of the P2X7 ion channel by soluble and covalently bound ligands. Purinergic Signal. 5: 139-149
- Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse AH, Seman M, Haag F, Koch-Nolte F. (2008) ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site. FASEB J 22: 861-869
- Möller S, Jung C, Adriouch S, Dubberke G, Seyfried F, Seman M, Haag F, Koch-Nolte F. (2007) Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation. Purinergic Signal 3: 359-366
- Koch-Nolte F, Reyelt R, Schössow B, Schwarz N, Scheuplein F, Rothenburg S, Haag F, Alzogaray V, Cauerhff A, Goldbaum F (2007) Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo. FASEB J 21: 3490- 3498
- Adriouch S, Hubert S, Pechberty S, Koch-Nolte F, Haag F, Seman M. (2007) NAD released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo. J Immunol 179: 186-194
- Mueller-Dieckmann C, Kernstock S, Lisurek M, von Kries JP, Haag F, Weiss MS, Koch-Nolte F. (2006) The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proc Natl Acad Sci U S A. 103: 15026-15031
- Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N,
Haag F, Koch-Nolte F. (2005) CD38 Controls ADP-Ribosyltransferase-2-Catalyzed ADPRibosylation
of T Cell Surface Proteins. J Immunol 174:1971-1979 - Bannas P, Adriouch S, Kahl S, Braasch F, Haag F, Koch-Nolte F. (2005) Activity and specifity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts. Blood 105: 3663-3670
