Prof. Dr. rer. nat. Matthias Leippe
Zoologisches Institut - Zoophysiologie, CAU Kiel
Born 21.12.1958
| 1977–1984 | Studies of Biology at University of Hamburg |
| 1984–1989 | Dissertation at the University of Hamburg (1987-1988 Civil Services) |
| 1989–2001 | Researcher at the Bernhard Nocht Institute for Tropical Medicine, Hamburg; Independent Group leader since 1993, Fellowship of the Heisenberg-Programm of the German Research Council (DFG) since 1997 |
| 1992–1993 | Guest scientist at the European Molecular Biology Laboratory (EMBL), Heidelberg |
| 1995 | Habilitation in Zoology at the University of Hamburg |
| 2001–2003 | C3 Professor, Molecular Parasitology, University of Würzburg |
| Since 2003 | C4 Professor and Director, Dept. Zoophysiology, Zoological Institute at the Christian-Albrechts-Universität Kiel |
10 Selected Publications
- Jung S, Dingley AJ, Augustin R, Anton-Erxleben F, Stanisak M, Gelhaus C, Gutsmann T, Hammer MU, Podschun R, Bonvin AMJJ., Leippe M, Bosch TCG, Grötzinger J. (2009) Hydramacin-1: Structure and antibacterial activity of a peptide from the basal metazoan Hydra. J Biol Chem 284: 1896-1905
- Fedders H, Michalek M, Grötzinger J, Leippe, M. (2008) An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of hemocytes of the marine invertebrate Ciona intestinalis. Biochem J 416: 65-75
- Schikorski D, Cuvillier-Hot V, Leippe M, Wichlacz-Boidin C, Slomianny C, Macagno E, Salzet M, Tasiemski A. (2008) Microbial challenge promotes the regenerative process of the injured central nervous system of the medicinal leech by inducing the synthesis of antimicrobial peptides in neurons and microglia. J Immunol 181: 1083-1095
- Schmidt H, Gelhaus C, Nebendahl M, Lettau M, Watzl C, Kabelitz, D, Leippe M, Janssen O. (2008) 2D-DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells. Proteomics 8: 2911- 2925
- Gelhaus C, Jacobs T, Andrä J, Leippe M (2008). The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum. Antimicrob. Agents Chemother 52: 1713-1720
- Harrington J M, Chou HT, Gutsmann T, Gelhaus C, Stahlberg H, Leippe M, Armstrong PB. (2008) Membrane pore formation by pentraxin proteins from Limulus, the American horseshoe crab. Biochem J 413: 305-313
- Gelhaus C, Fritsch J, Krause E, Leippe M. (2005) Fractionation and identification of proteins by two-dimensional electrophoresis and mass spectrometry: towards proteome analysis of Plasmodium falciparum. Proteomics 5: 4213-4222
- Müller I, Subert N, Otto H, Herbst R, Rühling H, Maniak M, Leippe M. (2005) A Dictyostelium mutant with reduced lysozyme levels compensates by increased phagocytic activity. J Biol Chem 280: 10435-10443
- Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guillen N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C, El-Sayed NM, Petri WA Jr, Clark CG, Embley TM, Barrell B, Fraser CM, Hall N. (2005) The genome of the protist parasite Entamoeba histolytica. Nature 433: 865-868
- Hecht O, van Nuland N, Schleinkofer K, Dingley AJ, Bruhn H, Leippe M, Grötzinger J. (2004) Solution structure of the pore-forming protein of Entamoeba histolytica. J Biol Chem 279: 17834-17841
