Dr. rer. nat. Sandra Pohl
Kinderklinik - Abteilung Biochemie, Universitätsklinikum Hamburg Eppendorf
Born 11.11.1975
| 1998–2003 | Studies of Biochemistry/Molecular Biology, University of Hamburg |
| 2003–2004 | Diploma Thesis, Biocenter Klein Flottbek, University of Hamburg |
| 2004–2007 | Doctoral Thesis, Department of Biochemistry, Children’s Hospital, UKE Hamburg |
| Since 2007 | Scientific Assistance and Group Leader, Department of Biochemistry, Children’s Hospital, UKE Hamburg |
Selected Publications
- Muschol N, Pohl S, Meyer A, Gal A, Ullrich K, Braulke T. (2011) Residual activity and proteasomal degradation of p.Ser298Pro sulfamidase identified in patients with a mild clinical phenotype of Sanfilippo A syndrome. Am J Med Genet A. 155A: 1634-1639.
- Marschner K, Kollmann K, Schweizer M, Braulke T, Pohl S. (2011) A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. Science. 333: 87-90.
- Lebrun A-H, Moll-Khosrawi P, Pohl S, Makrypidi G, Storch S, Kilian D, Streichert T, Otto B, Mole S E, Ullrich K, Cotman S, Kohlschütter A, Braulke T, Schulz A. (2011) Analysis of potential biomarkers and modifier genes affecting the clinical course of CLN3 disease. Mol Med. 17: 1253-1261
- Encarnação M, Kollmann K, Trusch M, Braulke T, Pohl S. (2011) Posttranslational modifications of the γ-subunit affect intracellular trafficking and complex assembly of the GlcNAc-1-phosphotransferase. J Biol Chem. 286: 5311-5318.
- Pohl S, Tiede S, Marschner K, Encarnação M, Castrichini M, Kollmann K, Muschol N, Ullrich K, Müller-Loennies S, Braulke T. (2010) Proteolytic processing of the γ-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages. J Biol Chem. 285: 23936-23944.
- Kollmann K, Pohl S, Marschner K, Encarnação M, Sakwa I, Tiede S, Poorthuis BJ, Lübke T, Müller-Loennies S, Storch S, Braulke T. (2009) Mannose phosphorylation in health and disease, Eur J Cell Biol, Eur J Cell Biol. 89: 117-123.
- Pohl S, Marschner K, Storch S, and Braulke T. (2009) Glycosylation- and phosphorylation dependent intracellular transport of lysosomal hydrolases. Biol Chem 390: 521-527
- Pohl S, Mitchison HM, Kohlschütter A, van Diggelen O, Braulke T, Storch S. (2007) Increased expression of lysosomal acid phosphatase (LAP/ACP2) in CLN3-defective cells and mouse brain tissue. J Neurochem 103: 2177-2188
- Storch S, Pohl S, Quitsch A, Falley K, Braulke T. (2007) C-Terminal prenylation of the CLN3 membrane glycoprotein is required for efficient endosomal sorting to lysosomes. Traffic 16: 431-444
- Storch S, Pohl S, Braulke T. (2004) A dileucine motif and a cluster of acidic amino acids in the second cytoplasmic domain of the batten disease-related CLN3 protein are required for efficient lysosomal targeting. J Biol Chem 279: 53625-53634
