Prof. Dr. rer. nat. Stefan Rose-John
Institute of Biochemistry, CAU Kiel
Born 17. 12. 1954
| 1973–1979 | Studies of Biology (Chemistry, Physics) at the University of Heidelberg |
| 1979–1982 | Dissertation at the University of Heidelberg |
| 1983–1984 | Research Associate, Michigan State University, USA |
| 1985–1988 | Scientific Assistant, Department of Biochemistry, DKFZ, Heidelberg |
| 1988–1994 | Scientific Assistant, Department of Biochemistry, RWTH Aachen |
| 1992 | Habilitation in Biochemistry RWTH Aachen |
| 1994–2000 | C3 Professor for Pathophysiology, I. Medical Clinic, University of Mainz |
| Since 2000 | C4 Professor and Chairman of the Department of Biochemistry at the Christian-Albrechts-Universität Kiel |
10 Selected Publications
- Grivennikov S, Karin E, Teric J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. (2009). IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer. Cancer Cell 15: 103-113.
- Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, Schmidt J, Galle PR, Rose-John S, Neurath MF. (2008) The transcription factor NFATc2 controls IL-6– dependent T cell activation in experimental colitis. J Exp Med 205:2099-2110
- Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones S, Rose-John S*, Scheller J (2007) Transgenic blockade of Interleukin-6-trans-signaling abrogates inflammation. Blood, 111: 1021-1028
- Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones S, Rose-John S*, Scheller J (2007) Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils. Blood 110: 1748-1755
- Chen Q, Fisher DT, Clancy KA, Gauguet J-M M, Wang W-C, Unger E, Rose-John S, von Andrian UH, Baumann H, and Evans SS (2006) Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules through an IL-6 trans-signaling mechanism. Nature Immunol 7: 1299-1308
- Stuhlmann-Laisz C, Lang S, Chalaris A, Sudarman E, Eichler J, Klingmüller U, Samuel M, Ernst M, Rose-John S*, and Scheller J (2006) Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells. Mol Biol Cell 17: 2986-2995
- Watt MJ, Dzamko N, Thomas W, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio MA, Steinberg GR. (2006) Ciliary neurotrophic factor reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Med. 12: 541-548
- Becker C, Fantini MC, Schramm C, Lehr HA, Nikolaev A, Wirtz S, Burg S, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF (2004) TGF-ß suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 21: 491-501
- Rose-John S and Neurath M (2004) IL-6 trans-signaling: The heat is on. Immunity 20: 2-4
- Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen K-J, Rose-John S, (2003) Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J. Biol. Chem. 278: 38829-38839
