Prof. Dr. med. Philip Rosenstiel
Institut für Klinische Molekularbiologie, CAU Kiel
Born 10. 10. 1973
| 1994–2001 | Study of Medicine at the Christian-Albrechts-University, Kiel, Germany and Tufts University, Boston, USA |
| 1997–1998 | Research scholarship (BMEP) at the Jackson Laboratory, Bar Harbor, USA. |
| 2003 | Dissertation in Medicine (‘summa cum laude’) |
| 2001–2005 | Internship and Resident at the 1st Medical Dept., Christian-Albrechts-University Hospital Kiel (Dir. Prof. Dr. med. U.R.Fölsch) |
| 2005–2006 | Group leader Cell biology at the Institute of Clinical Molecular Biology (Dir. Prof. Dr. med. S. Schreiber) |
| 2006–2007 | PostDoc (delegated) Max-Planck-Institute of Molecular Genetics, Berlin-Dahlem (Dir. Prof. H. Lehrach) |
| 2007 | Professorship (W2) in Experimental and Marine Medicine, University Kiel |
| Since 2008 | Deputy Director Institute of Clinical Molecular Biology, Kiel. Head of Functional Genomics and Cell Biology |
10 Selected Publications
- Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede KI, Schurmann M, Muller- Quernheim J, Krawczak M, Rosenstiel P, Schreiber S. (2008) Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet 40: 1103-1106
- Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, Mathew CG, Schreiber S. (2008) Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 40: 1319-1323
- Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Folsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S. (2007) Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. J Immunol 178: 8203-8211
- Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Gunther S, Prescott NJ, Onnie CM, Hasler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S. (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39: 207-211
- Weichart D, Gobom J, Klopfleisch S, Hasler R, Gustavsson N, Billmann S, Lehrach H, Seegert D, Schreiber S, Rosenstiel P. (2006) Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells. J Biol Chem 281: 2380-2389
- Rosenstiel P, Huse K, Till A, Hampe J, Hellmig S, Sina C, Billmann S, von Kampen O, Waetzig GH, Platzer M, Seegert D, Schreiber S. (2006) A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways. Proc Natl Acad Sci U S A 103: 3280-3285
- Waetzig GH, Rosenstiel P, Arlt A, Till A, Brautigam K, Schafer H, Rose-John S, Seegert D, Schreiber S. (2005) Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1. FASEB J 19: 91-93
- Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede KI, Franke A, Haesler R, Koch A, Lengauer T, Seegert D, Reiling N, Ehlers S, Schwinger E, Platzer M, Krawczak M, Muller-Quernheim J, Schurmann M, Schreiber S. (2005) Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet 37: 357-364
- Schreiber S, Rosenstiel P, Albrecht M, Hampe J, Krawczak M. (2005) Genetics of Crohn disease, an archetypal inflammatory barrier disease. Nat Rev Genet 6: 376-388
- Rosenstiel P, Fantini M, Bräutigam K, Kühbacher T, Waetzig GH, Seegert D, Schreiber S. (2003) TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124:1001-1009
