Prof. Dr. rer. nat. Paul Saftig
Institute of Biochemistry, CAU Kiel
Born 02. 09. 1962
| 1984–1990 | Studies of Biology at the University of Bonn and Norwich, U.K. |
| 1994 | Dissertation at the University of Göttingen, Biochemistry |
| 1985–1996 | Research Associate, University Göttingen, Biochemistry |
| 1996–2001 | Group leader, University Göttingen, Biochemistry |
| 2000 | Habilitation in Biochemistry, University Göttingen |
| since 2001 | C3 Professor and Director at the Department of Biochemistry at the Christian- Albrechts-Universität Kiel |
10 Selected Publications
- Saftig P, Klumperman J. (2009) Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat Rev Mol Cell Biol 10: 623-635
- Saftig P, Eskelinen EL (2008). Live longer with LAMP-2 Nature Med 14:909-910.
- Asagiri M., Hirai T.,Kunigami T., Kamano S., Gober H-J., Okamoto K., Nishikawa K., Latz E., Golenbock DT, Aoki K, Ohya K, Imai K, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H (2008) Cathepsin K-Dependent Toll-like Receptor 9 Signaling Revealed in Experimental Arthritis. Science, 319, 624-627
- Reczek D, Schwake M, Schröder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P (2007) LIMP-2 is a receptor for lysosomal mannose 6-phosphate independent targeting of beta-glucocerebrosidase. Cell, 131,770-783
- Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, Ryffel B, Barrat FJ, Saftig P, Levi F, Lidereau R, Nogues C, Mira JP, Chompret A, Joulin V, Clavel- Chapelon F, Bourhis J, Andre F, Delaloge S, Tursz T, Kroemer G, Zitvogel L (2007) Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med., 13,1050-1059
- Willem M, Garrat A, Novak B, Citron M, Kaufmann S, Rittger A, de Strooper B, Saftig P, Birchmeyer C, Haass C (2006) Control of peripheral myelination by the beta-secretase BACE-1. Science 314,664-666.
- Weskamp G, Ford J, Sturgill J, Martin S, Dogherty A, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Fujisawa-Sehara A, Black RA, Ludwig A, Becherer JD, Conrad D, Blobel C (2006) Identification of ADAM10 as a major sheddase of the low affinity IgE receptor CD23. Nature Immunol., 7, 1293-1298
- Reiß K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P (2005) DAM10 cleavage of Ncadherin and regulation of cell-cell adhesion and beta-catenin nuclear signaling. EMBO J. 24, 742-752
- Maretzky T, Reiß K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P (2005) ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration and beta-catenin translocation. Proc. Natl. Acad. Sci. USA 102, 9182-9187.
- Eskelinen EL, Tanaka Y, Saftig P (2003) At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol. 13, 137-145.
