Prof. Dr. rer. nat. Jürgen Scheller
Institut für Biochemie und Molekularbiologie II, Universität Düsseldorf
Born 10. 12. 1970
| 1991–1997 | Studies of Biology at University of Göttingen |
| 1999 | Doctorate (Dr. rer. nat.) |
| 1999-2002 | PostDoc Fellowship in Biotechnology, Leibniz-Institut IPK, Gatersleben |
| 2002-2008 | Assistant professor, Department of Biochemistry, University of Kiel |
| 2007 | Habilitation in Biochemistry, Faculty of Medicine, University of Kiel |
| since 2008 | W2-professor, Department of Biochemistry, University of Kiel |
10 Selected Publications
- Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J. (2009) Unraveling Viral Interleukin 6 binding to gp130 and activation of STAT-Signaling Pathways independent of Interleukin 6-Receptor. J Virol 83: 5117-5126
- Grivennikov S, Karin E, Teric J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. (2009) IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer. Cancer Cell 15: 103-113
- Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, Richards PJ, Slinn S, Ernst M, Jenkins BJ, Topley N, Rose-John S. Jones SA. (2009) Therapeutic targeting of IL-6 trans-signaling counteracts STAT3 control of the inflammatory infiltrate in experimental arthritis. J Immunol 182: 613-622
- Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones S, Rose-John S, Scheller J. (2008) Transgenic blockade of Interleukin-6-trans-signaling abrogates inflammation. Blood 111: 1021-1028
- West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C. (2008) TLRligand induced podosome disassembly in dendritic cells is ADAM17 dependent. J Cell Biol 182: 993-1005
- Chalaris A, Rabe B, Paliga K, Laskay T, Ludwig A, Lange H, Rose-John S, Scheller J. (2007) Caspase-dependent ADAM17-mediated IL-6R-shedding during the early phase of intrinsic and extrinsic apoptosis. Blood110: 1748-1755
- Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose- John S, Neurath MF, Becker C. (2007) Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells. J Immunol 179: 2041-2045
- Lin M, Rose-John S, Grötzinger J, Conrad U, Scheller J. (2006) The functional expression of a biologically active fragment of soluble gp130 as an ELP fusion protein in transgenic plants: purification via inverse-transition-cycling. Biochem J 398: 577-583
- Kovaleva M, Bußmeyer I, Rabe B, Grötzinger J, Sudarman E, Eichler J, Conrad J, Rose-John S, Scheller J. (2006) Abrogation of vIL-6 induced signaling by intracellular retention and neutralization of vIL-6 with an anti vIL-6 single-chain antibody selected by phage display. J. Virol 80: 8510-8520
- Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, Handa K, Tsuruta O, Funabashi H, Scheller J, Toyonaga A, Sata M. (2006) STAT3 activation via interleukin-6 trans-signaling contributes to ileitis in SAMP1/Yit mice. Gut 55: 1263-1269
