Prof. Dr. rer. nat. Stefan Schütze
Institut für Immunologie, CAU Kiel
Born 19. 09. 1950
| 1971–1978 | Studies of Biology at the Free University of Berlin |
| 1981–1983 | Dissertation at the Free University of Berlin |
| 1983–1986 | Scientific Assistant, Institute for Molecular Biology, Free University of Berlin |
| 1986–1991 | Scientific Assistant, Clinical Research Group, Max-Planck-Institute Göttingen |
| 1991–1995 | Scientific Assistant, Institute for Clinical Microbiology, TU München |
| 1995 | Habilitation in Immunology, Faculty of Medicine, University of München |
| since 1995 | Principal Investigator at the Institute of Immunology, University of Kiel |
| 2001 | Vice-Director, Institute of Immunology, University of Kiel |
| 2002 | Professor, Institute of Immunology, University of Kiel |
10 Selected Publications
- Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M. (2009) Riboflavin kinase couples TNF Receptor 1 to NADPH oxidase. Nature 460: 1159-1163
- Schütze S, Tchikov V, Schneider-Brachert W. (2008) Regulation of TNF-R1 and CD95 signalling by receptor compartmentalization. Nat Rev Mol Cell Biol 9: 655-662
- Liao W, Xiao Q, Liao Z, Wincovitch S, Garfield S, Yang W, Tchikov V, Schütze S, El-Deiry W, Srinivasula SM. (2008) CARP-2 is an endosomal ubiquitin protein ligase for RIP and regulates TNFinduced NF-κB activation. Current Biology 18: 641-649
- von Bismarck P, Wistädt CFG, Klemm K, Winoto-Morbach S, Uhlig U, Adam D, Schütze S, Uhlig S, Lachmann B, Krause MF. (2008) Reduced acid sphingomyelinase activity improves lung edema and gas exchanges in a newborn piglet lavage model, Am J of Resp and Crit Care Med 177: 1233- 1241
- Feig C, Tchikov V, Schütze S, Peter ME. (2007) Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. EMBO J 26: 221-231 6. Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schütze S, Peter ME, Chan AC. (2006) The role of receptor internalization in CD95 signaling. EMBO J 25: 1009-1023
- Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schütze S, Peter ME, Chan AC. (2006) The role of receptor internalization in CD95 signaling. EMBO J 25: 1009-1023
- Schneider-Brachert W, Tchikov V, Kruse ML, Lehn A, Jakob M, Hallas C, Hildt E, Held-Feindt J, Kabelitz D, Krönke M, Schütze S. (2006) Inhibition of TNF receptor 1 internalization by adenovirus E3-14.7K as a novel immune escape mechanism. J Clin Invest 116: 2901-2913
- Schneider-Brachert W, Tchikov V, Held-Feindt J, Winoto-Morbach S, Neumeyer J, Jakob M, Merkel O, Ehrenschwender M, Heinrich D, Adam D, Kabelitz D, Schütze S. (2004) Compartmentalization of TNF receptor-1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21: 415-428
- Göggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky S, Schütze S, Gulbins E, Uhlig S. (2004) PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med 10: 155-160
- Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, Trauzold A, Hethke A, Schütze S. (2004) Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and caspase-3 activation. Cell Death Differ 11: 550-563
