Proteolysis as a Regulatory Event in Pathophysiology

PD Dr. rer. nat. Michael Schwake

Biochemisches Institut, CAU Kiel

Born 18. 04. 1970

1991–1997	Biochemistry, Free University of Berlin
1996–1997	Diploma thesis in the laboratory of Prof. F. Hucho at the Free University of Berlin
1997	Diploma (Free University of Berlin)
1995	University of Cape Town, Prof. Dr. H. H. Klump
1996	University of California, San Francisco, Prof. R. B. Kelly
1996	University of Washington, Seattle, Prof. Dr. W. A. Catterall
1997–2001	PhD. thesis at the Center for Molecular Neurobiology in Hamburg in the laboratory of Prof. Dr. T. J. Jentsch, Ph.D. (Free University of Berlin)
2002	Postdoc at the Stanford University, Prof. Dr. S. R. Pfeffer
Since 2002	Group leader at the University of Kiel in the laboratory of Prof. Dr. P. Saftig Habilitation in Biochemistry (Christian-Albrechts- University of Kiel)

 

10 Selected Publications

• Lange W, Geissendörfer J, Schenzer A, Grötzinger J, Seebohm G, Friedrich T, Schwake M. (2009). Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels. Mol Pharmacol 75: 272-280
• Shuk Yin M Yeung, Schwake M, Pucovský V, Greenwood IA. (2008) Bimodal effects of the K_v7 channel activator retigabine on vascular K⁺ currents. Br J Pharmacol 155: 62-72
• Reczek* D, Schwake* M, Schröder* J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P. (2007) Lysosomal integral membrane protein-2 (LIMP-2) is a receptor for lysosomal mannose 6-phosphate independent targeting of β-glucocerebrosidase. Cell 131: 770- 783.
• Wehling C, Beimgraben C, Gelhaus C, Friedrich T, Saftig P, Grötzinger J, Schwake M. (2007) Self-Assembly of the isolated KCNQ2 subunit interaction domain. FEBS Lett 581: 1594-1598.
• Shuk Yin M Yeung, Pucovsky V, Moffatt JD, Saldanha L, Johnston S, Kaan T, Yip PK, Schwake M, Ohya S, Greenwood IA. (2007) Novel identification of a functional role of K⁺ channels encoded by KCNQ2-5 in murine vascular reactivity. Brit J Pharmacol 151: 758-770
• Schroen B, Leenders JJ, van Erk A, Bertrand B T, van Loon M, van Leeuwen RE, Kubben N, Duisters RF, Schellings MW, Janssen BJ, Debets JJ, Schwake M, Heymans S, Saftig P, Pinto YM. (2007) Lysosomal integral membrane protein-2 is a novel component of intercalated discs and prevents dilated cardiomyopathy. J Exp Med 204: 1227-1235
• Knipper M, Claussen C, Rüttiger L, Zimmermann U, Lüllmann-Rauch R, Eskelinen EL, Schröder J, Schwake M, Saftig P. (2006) Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis. J Physiol 576: 73-86.
• Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch TJ, Saftig P, Friedrich T. (2006) Structural determinants of M-type KCNQ (K_v7) K⁺ channel assembly. J Neurosci 26: 3757-3766
• D'Hooge R, Lullmann-Rauch R, Beckers T, Balschun D, Schwake M, Reiss K, von Figura K, Saftig P. (2005) Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis. J Neurosci 25: 6539-6549
• Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grotzinger J, Schwake M. (2005) Molecular determinants of KCNQ (K_v7) K⁺ channel sensitivity to the anticonvulsant retigabine. J Neurosci 25: 5051-5060

* equally contributed.