The Symposium was organized by the members of the CRC877 from institutes at the University of Kiel, the University Medical Center Schleswig-Holstein & the University Medical Center Hamburg-Eppendorf:
Biochemisches Institut, Kiel; Institut für Immunologie, Kiel; III Med Klinik UKE Hamburg; Klinik für Dermatologie, Kiel; Institut für Immunologie, UKE Hamburg; Kinderkl.-Biochemie, UKE Hamburg; Klin. Molekularbiologie, Kiel; Institut für Experimentelle Medizin, Kiel
Proteases constitute 1%–5% of eukaryotic genes and the human genome encodes 566 predicted proteolytic enzymes. The functions of proteases are essential in many physiological processes, including development, blood coagulation, and cell death, as well as many pathophysiologic events such as inflammation, cancer and infectious diseases. The general aim of the CRC 877 is to obtain a profound understanding of proteolytic processes in cellular regulation and signaling and to define the involvement of such processes in human pathophysiology.
The process of proteolysis is, in contrast to other posttranslational modifications such as protein phosphorylation, protein lipidation or protein methylation, completely irreversible. Therefore – at least theoretically – it might represent an entirely different and presumably higher level of regulation than the other mentioned protein modifications.