Univ. Prof. Dr. rer. nat Stefan Rose-John
Tel.
: 0431/880- 3336 or -2018 (secretary) Fax
: 0431/880-5007 Mail
:
Molecular Biology Of Cytokines, Chemokines And Metalloproteinase
| · | Structural aspects of cytokines and cytokine receptor complexes | |
| · | Biochemistry and physiology of soluble cytokine receptors | |
| · | Characterization of shedding enzymes | |
| · | Role of cytokines in cellular differentiation | |
| · | Molecular and physiological characterization of viral cytokines | |
| · | Molecular and physiological characterization of matrix metalloproteinases | |
| Research is carried out in the following units | ||
|
Prof. Dr. S. Rose-John | Molekulare Biologie der Zytokine |
|
Prof. Dr. H. Lemke | Biochemie des Immunsystems |
|
Prof. Dr. J. Grötzinger | Strukturbiologie |
|
Dr. H. Hansen | Shedding von Oberflächenproteinen |
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 THE DESIGNER CYTOKINE HYPER-IL-6 Hyper-IL-6: a highly active designer cytokine consisting of Interleukin-6
(IL-6) and soluble Interleukin-6 receptor (sIL-6R). Molecular model
of the fusion protein consisting of IL-6 (gray) and sIL-6R (yellow)
fused by a flexible peptide linker (green). A, B, C, and D denote the
four helices of IL-6; D-II and D-III are the two cytokinebinding receptor
domains of the soluble IL-6R used for the construction of the fusion
protein. The fusion protein Hyper-IL-6 is 100-1000 times more active
than the separate proteins IL-6 and sIL-6R. Hyper-IL-6 can be used to
stimulate several types of target cells, which are not stimulated by
IL-6 alone, since they do not express the membrane bound IL-6R. Such
cells include embryonic stem cells, endothelial cells, hematopoietic
progenitor cells, osteoclasts and neuronal cells. |