Department of Clinical Pharmacy
 

Prof. Dr. Thomas Kunze

+49-(0)431- 880-1331

E-Mail

 
in englishgerman
 
Research topics
Publications
Curriculum vitae
Staff
C U R R I C U L U M    V I T A E
     
  1960 born
  1980-1984 School of Pharmacy, University of Marburg
  1990 Dr. rer. nat. with Prof. Dr. B. Clement, Dept. of Pharmaceutical Chemistry, University of Marburg
  1990-1996 Wissenschaftlicher Assistent, Uni Kiel
  1997 Habilitation in Pharmaceutical Chemistry, Pharmaceutical and Medicinal Institute, University of Kiel
  since 2009 apl. Professor of Clinical Pharmacy, Pharmaceutical Institute, University of Kiel
 
L I T E R A T U R E
       
 
1.
  B. Clement und T. Kunze, Zur mikrosomalen N-Hydroxylierung des Adenins,
Arch. Pharm. 321, 601 (1988).
 
2.
  B. Clement and T. Kunze, Hepatic microsomal N-hydroxylation of adenine to 6-
N-hydroxylaminopurine, Biochem. Pharmacol. 39, 925-933 (1990).
 
3.
  B. Clement, K. Lustig, H. Pfundner und T. Kunze, Untersuchungen von N-
oxidativen Biotransformationsvorgängen mit gereinigten Enzymen, Arch. Pharm.
(Weinheim) 323, 663 (1990).
 
4.
  B. Clement und T. Kunze, Die Reduktion von 6-N-Hydroxyaminopurin durch
Xanthin Oxidase, Pharm. Unserer Zeit 20, 124 (1991).
 
5.
  B. Clement and T. Kunze, The reduction of 6-N-hydroxylaminopurine to adenine by xanthine oxidase, Biochem. Pharmacol. 44, 1501-1509 (1992).
 
6.
  B. Clement and T. Kunze, Microsomal N-oxygenation of adenine to adenine 1-N-
oxide, Arch. Pharm. 326, 25-27 (1993).
 
7.
  B. Clement and T. Kunze, The in vitro oxygenation of N,N'-diphenylguanidines,
Xenobiotica 23, 155-167 (1993).
 
8.
  T. Kunze, Neue Glutathion-Analoga als Hemmstoffe von gereinigten Glutathion
S-Transferasen, Arch. Pharm. 326, 579 (1993).
 
9.
  T. Kunze, Purification and biochemical characterization of the major cytosolic
glutathione S-transferases from pig liver, Eur. J. Pharm. Sci. 2, 173 (1994).
 
10.
  T. Kunze, Isolation and Biochemical characterization of the major cytosolic
glutathione S-transferases from porcine liver - comparision with the
corresponding human enzymes, ISSX-Proceedings 7, 79 (1995).
 
11.
  T. Kunze, Phosphono analogues of glutathione as new inhibitors of glutathione
S-transferases, Arch. Pharm. Pharm. Med. Chem. 329, 503-509 (1996).
 
12.
  T. Kunze, Purification and characterization of class Alpha and Mu glutathione S-
transferase from porcine liver, Comp. Biochem. Physiol. 116B, 397-406 (1997).
 
13.
  T. Kunze and S. Heps, Phosphono analogues of glutathione: Inhibition of
glutathione transferases, metabolic stability and uptake by cancer cells,
Biochem. Pharmacol. 59, 973-981 (2000).
 
14.
  Xie WZ, Leibl M, Clark MR, Dohrmann P, Kunze T, Gieseler F., Activation of the
coagulation system in cancerogenesis and metastasation. Biomed
Pharmacother. 59, 70-75 (2005).
 
15.
  Zebothsen I, Kunze T, Clement B., Inhibitory effects of cytostatically active 6-
aminobenzo[c]phenanthridines on cytochrome P450 enzymes in human hepatic
microsomes. Basic Clin Pharmacol Toxicol. 99, 37-43 (2006).
 
16.
  Clement B, Kunze T, Heberling S., Reduction of N-omega-hydroxy-L-arginine to
L-arginine by pig liver microsomes, mitochondria, and human liver microsomes.
Biochem Biophys Res Commun. 349, 869-873 (2006).
 
17.
  Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B.,
Identification of the missing component in the mitochondrial benzamidoxime
prodrug-converting system as a novel molybdenum enzyme. J Biol Chem. 281,
34796-34802 (2006).
 
18.
  Gieseler F, Lühr I, Kunze T, Mundhenke C, Maass N, Erhart T, Denker M,
Beckmann D, Tiemann M, Schulte C, Dohrmann P, Cavaillé F, Godeau F,
Gespach C., Activated coagulation factors in human malignant effusions and
their contribution to cancer cell metastasis and therapy. Thromb Haemost. 97,
1023-1030 (2007).
 
19.
  Gieseler F, Stelck B, Blume LF, Denker M, Dohrmann P, Mundhenke C,
Bauerschlag D, Tiemann M, Kunze T., Coagulation and formation of malignant
effusions. Hamostaseologie. 27, 273-277 (2007).
 
20.
  Bürenheide A, Kunze T, Clement B, Inhibitory effects on cytochrome p450
enzymes of pentamidine and its amidoxime pro-drug. Basic Clin Pharmacol
Toxicol. 103, 61-65, (2008).
 
21.
  Blume L-F, Denker M, Gieseler F, Kunze T, Temperature corrected
transepithelial electrical resistance (TEER)
measurement to quantify rapid changes in paracellular permeability.
 
   
R E S E A R C H   T O P I C S
       
     
  • Clinical Pharmacy in cooperation with colleagues of the medicinal faculty of the CAU Kiel.
  • Therapy optimization malignancies.
  • Resistance modulation of cancer therapy.
  • Enzyme kinetics
  • Genetic polymorphism
  • Transepithelial electrical resistance
  • Adhesion, migration and invasion of cancer cells
       
S T AF F
     

 

 

Ebbing, Laura , Wissenschaftliche Mitarbeiterin / Ph. D. Student . Tel.: +49-(0) 431-880-5381

Gersonde, Franziska, Wissenschaftliche Mitarbeiterin / Ph. D. Student, Tel.: +49-(0)431-880-5381