Prof. Dr. Thomas Kunze

Department of Clinical Pharmacy

+49-(0)431- 880-1331

	Research topics
	Publications
	Curriculum vitae
	Staff


C U R R I C U L U M V I T A E

	1960		born
	1980-1984		School of Pharmacy, University of Marburg
	1990		Dr. rer. nat. with Prof. Dr. B. Clement, Dept. of Pharmaceutical Chemistry, University of Marburg
	1990-1996		Wissenschaftlicher Assistent, Uni Kiel
	1997		Habilitation in Pharmaceutical Chemistry, Pharmaceutical and Medicinal Institute, University of Kiel
	since 2009		apl. Professor of Clinical Pharmacy, Pharmaceutical Institute, University of Kiel

L I T E R A T U R E

	1.	B. Clement und T. Kunze, Zur mikrosomalen N-Hydroxylierung des Adenins, Arch. Pharm. 321, 601 (1988).
	2.	B. Clement and T. Kunze, Hepatic microsomal N-hydroxylation of adenine to 6- N-hydroxylaminopurine, Biochem. Pharmacol. 39, 925-933 (1990).
	3.	B. Clement, K. Lustig, H. Pfundner und T. Kunze, Untersuchungen von N- oxidativen Biotransformationsvorgängen mit gereinigten Enzymen, Arch. Pharm. (Weinheim) 323, 663 (1990).
	4.	B. Clement und T. Kunze, Die Reduktion von 6-N-Hydroxyaminopurin durch Xanthin Oxidase, Pharm. Unserer Zeit 20, 124 (1991).
	5.	B. Clement and T. Kunze, The reduction of 6-N-hydroxylaminopurine to adenine by xanthine oxidase, Biochem. Pharmacol. 44, 1501-1509 (1992).
	6.	B. Clement and T. Kunze, Microsomal N-oxygenation of adenine to adenine 1-N- oxide, Arch. Pharm. 326, 25-27 (1993).
	7.	B. Clement and T. Kunze, The in vitro oxygenation of N,N'-diphenylguanidines, Xenobiotica 23, 155-167 (1993).
	8.	T. Kunze, Neue Glutathion-Analoga als Hemmstoffe von gereinigten Glutathion S-Transferasen, Arch. Pharm. 326, 579 (1993).
	9.	T. Kunze, Purification and biochemical characterization of the major cytosolic glutathione S-transferases from pig liver, Eur. J. Pharm. Sci. 2, 173 (1994).
	10.	T. Kunze, Isolation and Biochemical characterization of the major cytosolic glutathione S-transferases from porcine liver - comparision with the corresponding human enzymes, ISSX-Proceedings 7, 79 (1995).
	11.	T. Kunze, Phosphono analogues of glutathione as new inhibitors of glutathione S-transferases, Arch. Pharm. Pharm. Med. Chem. 329, 503-509 (1996).
	12.	T. Kunze, Purification and characterization of class Alpha and Mu glutathione S- transferase from porcine liver, Comp. Biochem. Physiol. 116B, 397-406 (1997).
	13.	T. Kunze and S. Heps, Phosphono analogues of glutathione: Inhibition of glutathione transferases, metabolic stability and uptake by cancer cells, Biochem. Pharmacol. 59, 973-981 (2000).
	14.	Xie WZ, Leibl M, Clark MR, Dohrmann P, Kunze T, Gieseler F., Activation of the coagulation system in cancerogenesis and metastasation. Biomed Pharmacother. 59, 70-75 (2005).
	15.	Zebothsen I, Kunze T, Clement B., Inhibitory effects of cytostatically active 6- aminobenzo[c]phenanthridines on cytochrome P450 enzymes in human hepatic microsomes. Basic Clin Pharmacol Toxicol. 99, 37-43 (2006).
	16.	Clement B, Kunze T, Heberling S., Reduction of N-omega-hydroxy-L-arginine to L-arginine by pig liver microsomes, mitochondria, and human liver microsomes. Biochem Biophys Res Commun. 349, 869-873 (2006).
	17.	Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B., Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme. J Biol Chem. 281, 34796-34802 (2006).
	18.	Gieseler F, Lühr I, Kunze T, Mundhenke C, Maass N, Erhart T, Denker M, Beckmann D, Tiemann M, Schulte C, Dohrmann P, Cavaillé F, Godeau F, Gespach C., Activated coagulation factors in human malignant effusions and their contribution to cancer cell metastasis and therapy. Thromb Haemost. 97, 1023-1030 (2007).
	19.	Gieseler F, Stelck B, Blume LF, Denker M, Dohrmann P, Mundhenke C, Bauerschlag D, Tiemann M, Kunze T., Coagulation and formation of malignant effusions. Hamostaseologie. 27, 273-277 (2007).
	20.	Bürenheide A, Kunze T, Clement B, Inhibitory effects on cytochrome p450 enzymes of pentamidine and its amidoxime pro-drug. Basic Clin Pharmacol Toxicol. 103, 61-65, (2008).
	21.	Blume L-F, Denker M, Gieseler F, Kunze T, Temperature corrected transepithelial electrical resistance (TEER) measurement to quantify rapid changes in paracellular permeability.

R E S E A R C H T O P I C S

		Clinical Pharmacy in cooperation with colleagues of the medicinal faculty of the CAU Kiel. Therapy optimization malignancies. Resistance modulation of cancer therapy. Enzyme kinetics Genetic polymorphism Transepithelial electrical resistance Adhesion, migration and invasion of cancer cells

S T AF F
			Ole Helm, Diplomand, Tel. +49-(0)-431-597-143 Knudsen, Lena , Wissenschaftliche Mitarbeiterin / Ph. D. Student . Tel.: +49-(0) 431-880-5381 Denker, Momme, Wissenschaftliche Mitarbeiterin / Ph. D. Student, Tel.: +49-(0)431-880-5381