2012
Hattermann, K., and Mentlein, R. Trio infernal: The chemokine CXCL12 and its both receptors CXCR4 and CXCR7 in tumor biology. Ann. Anat., in press.
Held-Feindt J, Schmelz S, Hattermann K, Mentlein R, Mehdorn HM, Sebens S. The neural adhesion molecule L1CAM confers chemoresistance in human glioblastomas. Neurochem Int., in press.
Hattermann K, Mentlein R, Held-Feindt J. CXCL12 mediates apoptosis resistance in rat C6 glioma cells. Oncology Reports 27:1348-52, 2012.
Mentlein R, Hattermann K, Held-Feindt J. Lost in disruption: Role of proteases in glioma invasion and progression. Biochim Biophys Acta - Rev. Cancer 825:178-85, 2012.
Odemis V, Lipfert J, Kraft R, Hajek P, Abraham G, Hattermann K, Mentlein R, Engele J. The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells. Glia 60:372-81, 2012.
Lippross S, Klueter T, Steubesand N, Oestern S, Mentlein R, Hildebrandt F, Podschun R, Pufe T, Seekamp A, Varoga D. Multiple trauma induces serum production of host defence peptides. Injury, Int. J. Care Injured 43:137-42, 2012.
2011
Meincke M, Tiwari S, Hattermann K, Kalthoff H, Mentlein R. Near-infrared molecular imaging of tumors via chemokine receptors CXCR4 and CXCR7. Clin Exp Metastasis 28: 713-20, 2011.
Hattermann K, Held-Feindt J, Mentlein R. Spheroid confrontation assay: A simple method to monitor the three-dimensional migration of different cell types in vitro. Ann Anat 193:181-184, 2011.
Mentlein R, Hattermann K, Hemion C, Jungbluth A, Held-Feindt J. Expression and role of the cell surface protease seprase/fibroblast activation protein-α (FAP-α) in astroglial tumors. Biol Chem 392, 199-207, 2011.
Held-Feindt J, Hattermann K, Knerlich-Lukoschus F, Mehdorn HM, Mentlein R. SP100 reduces malignancy of human glioma cells. Int J Oncol 38: 1023-30, 2011.
Schlorf T, Meincke M, Kossel E, Glüer CC, Jansen O, Mentlein R. Biological properties of iron oxide nanoparticles for cellular and molecular magnetic resonance imaging. Int J Mol Sci 12: 12-23, 2011.
2010
Hattermann K, Held-Feindt J, Lucius R, Sebens Müerköster S, Penfold M E T, Schall T J, Mentlein R. The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates anti-apoptotic effects. Cancer Res 70: 3299-308, 2010.
Held-Feindt J, Hattermann K, Müerköster SS, Wedderkopp H, Knerlich-Lukoschus F, Ungefroren H, Mehdorn HM, Mentlein R. CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). Exp Cell Res 16: 1553-66, 2010.
Lettau I, Hattermann K, Held-Feindt J, Brauer R, Sedlacek R, Mentlein R. Matrix Metalloproteinase-19 is Highly Expressed in Astroglial Tumors and Promotes Invasion of Glioma Cells. J Neuropathol Exp Neurol 69:215-23, 2010.
Lemke AK, Sandy JD, Voigt H, Dreier R, Lee JH, Grodzinsky AJ, Mentlein R, Fay J, Schünke M, Kurz B. Interleukin-1α treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2. Cell Tissue Res 340:179-88, 2010.
Akay I, Oxmann D, Helfenstein A, Mentlein R, Schünke M, Hassenpflug J, Kurz B. Tumor risk by tissue engineering: cartilaginous differentiation of mesenchymal stem cells reduces tumor growth. Osteoarthritis Cartilage 18:389-96, 2010.
Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P. ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma. J Invest Dermatol 130: 763-73, 2010.
Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P. ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma. J Invest Dermatol 130: 763-73, 2010.
2009
Kranich S, Hattermann K, Specht A, Lucius R, Mentlein R. VEGFR-3/Flt-4
mediates proliferation and chemotaxis in glial precursor cells.
Neurochem Int 55: 747-753, 2009.
Voigt H, Lemke AK, Mentlein R, Schünke M, Kurz B. Tumor
necrosis factor alpha-dependent aggrecan cleavage and release
of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent
aggrecanase activity in vitro. Arthritis Res Ther 11: R141, 2009.
Mentlein R. Mechanisms underlying the rapid degradation and elimination
of the incretin hormones GLP-1 and GIP. Best Pract Res Clin Endocrinol
Metab 23: 443-452, 2009.
Minsel I, Mentlein R, Sel S, Diebold Y, Bräuer L, Mühlbauer
E, Paulsen FP. Somatostatin actions via somatostatin receptors
on the ocular surface are modulated by inflammatory processes.
Endocrinology 150: 2254-2263, 2009.
Varoga D, Wruck CJ, Tohidnezhad M, Brandenburg L, Paulsen F,
Mentlein R, Seekamp A, Besch L, Pufe T. Osteoblasts participate
in the innate immunity of the bone by producing human beta defensin-3.
Histochem Cell Biol 131: 207-18, 2009.
2008
Varoga D, Tohidnezhad M, Paulsen F, Wruck CJ, Brandenburg
L, Mentlein R, Lippross S, Hassenpflug J, Besch L, Müller
M, Jürgens C, Seekamp A, Schmitt L, Pufe T. The role of human
beta-defensin-2 in bone. J Anat 213: 749-757, 2008.
Hattermann K, Ludwig A, Gieselmann V, Held-Feindt J, Mentlein
R. The chemokine CXCL16 induces migration and invasion of glial
precursor cells via its receptor CXCR6. Mol Cell Neuroscience
39: 133-141,2008.
Ludwig A, Mentlein R. Gial cross-talk by transmemberane chemokines
CX3CL1 and CXCL16. J. Neuroimmunol 198: 92-97, 2008.
Beck IM, Rückert R, Brandt K, Mueller MS, Sadowski T, Brauer
R, Schirmacher P, Mentlein R, Sedlacek R. MMP19 is essential for
T cell development and T cell-mediated cutaneous immune responses.
PLOS One 3: e2343 (1-11), 2008.
Meincke M, Schlorf T, Kossel E Jansen O, Glüer C-C, Mentlein
R. Iron oxide - loaded liposomes for MR imaging. Frontiers Bioscience
13: 4002-4008, 2008.
Hattermann K, Mehdorn HM, Mentlein R, Schultka S, Held-Feindt
J. A methylation-specific and SYBER®-Green-based quantitative
PCR technique for MGMT promoter methylation analysis. Anal Biochem
377: 62-71, 2008.
Held-Feindt J, Rehmke B, Mentlein R, Hattermann K, Knerlich F,
Hugo H-H, Ludwig A, Mehdorn HM. Overexpression of CXCL16 and its
receptor CXCR6/Bonzo promotes growth of human schwannomas. Glia
56: 764-774, 2008.
Oxman D, Held-Feindt J, Stark AM, Hattermann K, Yoneda T, Mentlein
R. Endoglin expression in metastatic breast cancer cells enhances
their invasive phenotype. Oncogene 27: 3567-3575. 2008.
Pufe T, Petersen W, Fändrich F, Varoga D, Wruck CJ, Mentlein
R, Helfenstein A, Hoseas D, Dressel S, Tillmann B, Ruhnke M. Programmable
cells of monocytic origin (PCMO): a source of peripheral blood
stem cells that generate collagen type II-producing chondrocytes.
J Orthop Res 26: 304-13, 2008.
Ma Y, Mentlein R, Kruse ML, Knerlich F, Mehdorn HM, Held-Feindt
J. Expression of tumor stem cell markers in astrocytomas of different
WHO grades. J Neuro-Oncol 86: 31-45, 2008.
2007
Beck IM, Müller M, Mentlein R, Sadowski T, Mueller MS, Paus
R, Sedlacek R. Matrix metalloproteinase-19 expression in keratinocytes
is repressed by transcription factors Tst-1 and Skn-1a: implications
for keratinocyte differentiation. J Invest Dermatol 127: 1107-14,
2007.
Tong Y, Mentlein R, Buhl R, Hugo H-H, Mehdorn HM, Held-Feindt
J. Overexpression of midkine contributes to anti-apoptotic effects
in human meningiomas. J Neurochem 100: 1097-1107, 2007
Stark AM, Anuszkiewicz B, Mentlein R, Yoneda T, Mehdorn HM, Held-Feindt
J. Differential expression of matrix metalloproteinases in brain-
and bone-seeking clones of metastatic MDA-MB-231 breast cancer
cells. J Neuro-Oncol 81: 39-48, 2007.
Pufe T, Groth G, Goldring MB, Tillmann B, Mentlein R. Effects
of pleiotrophin, a heparin-binding growth factor, on human primary
and immortalized chondrocytes. Osteoarthritis Cartilage 15: 155-62,
2007.
Koch, M., May, U., Kuhns, S., Drechsler, H., Adam, N., Hattermann,
K., Wirtz, S., Rose-John, S., and Scheller, J. Interleukin 27
induces differentiation of neural C6-precursor cells into astrocytes.
Biochem Biophys Res Commun. 364: 483-7, 2007.
Mentlein, R. Targeting pleiotrophin to treat osteoarthritis.
Expert Opinion on Therapeutic Targets 11: 861-867, 2007.
2006
Varoga, D., Paulsen, F., Mentlein, R., Fay, J., Kurz,
B., Schutz, R., Wruck, C., Goldring, M., and Pufe, T. (2006).
TLR-2-mediated induction of vascular endothelial growth factor
(VEGF) in cartilage in septic joint disease. J. Pathol. 210, 315-324.
Held-Feindt, J., Dörner, L., Gülcan, S., Mehdorn, H.
M., and Mentlein, R. (2006). Cannabinoid receptors in human gliomas. J. Neurochem. 98, 886-893.
Schindler, R., and Mentlein, R. (2006) Flavonoids and vitamin
E reduce the release of the angiogenic peptide vascular endothelial
growth factor from human tumor cells. J. Nutrition 136,
1477-1482.
Mentlein, R., Stec, I., und Wiegers G. J. (2006). Immunologie
des Thymus und Einflüsse des Nervensystems und der Glucokortikoide.
In: "Lehrbuch der klinischen Pathophysiologie komplexer chronischer
Erkrankungen. Band 1, Physiologische Grundlagen" (R. H. Straub,
Ed.), S. 119-129. Vandenhoeck & Ruprecht, Göttingen.
Varoga, D., Paulsen, F. P., Kohrs, S., Grohmann, S., Lippross,
S., Mentlein, R., Tillmann, B. N., Goldring, M. B., Besch, L.,
and Pufe, T. (2006). Expression and regulation of human beta-defensin
2 in osteoarthritic cartilage. J. Pathol. 209, 166-173.
Held-Feindt, J., Bernedo Paredes, E., Blömer, U., Seidenbecher,
C., Stark, A. M., Mehdorn, H. M., and Mentlein, R. (2006). The
matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and
metalloproteinases with thrombospondin motifs 4 and 5) are expressed
in human glioblastomas. Int. J. Cancer 118, 55-61.
2005
Mentlein, R. (2005). Dipeptidyl-peptidase
IV and aminopeptidase P: molecular switches of NPY/PYY receptor
affinities. In: "The NPY Family of Peptides in Immune Disorders,
Inflammation, Angiogenesis and Cancer" (Z. Zukowska, G. Z.
Feuerstein, Eds.). Birkhäuser-Verlag, Basel, pp. 75-84.
Varoga, D., Pufe,
T., Mentlein, R., Kohrs, S., Grohmann, S., Tillmann, B., Hassenpflug,
J., and Paulsen, F. (2005). Expression and regulation of antimicrobial
peptides in articular joints. Ann. Anat. 187, 499-508.
Pufe, T., Kurz, B.,
Petersen, W., Varoga, D., Mentlein, R., Kulow, S., Lemke, A.,
and Tillmann, B. (2005). The influence of biomechanical parameters
on the expression of VEGF and endostatin in the bone and joint
system. Ann. Anat. 187, 461-72.
Pufe, T., Petersen,
W., Mentlein, R., and Tillmann, B. (2005). The role of vasculature
and angiogenesis for the pathogenesis of degenerative tendons
disease. Scand. J. Med. Sci. Sports 15, 211-22.
Ludwig, A., Schulte,
A., Schnack, C., Hundhausen, C., Reiss, K., Brodway, N., Held-Feindt,
J., and Mentlein, R. (2005). Enhanced expression and shedding
of the transmembrane chemokine CXCL16 by reactive astrocytes and
glioma cells. J. Neurochem. 93, 1293-1303.
Varoga, D., Pufe,
T., Harder, J., Schröder, J.-M., Mentlein, R., Meyer-Hoffert,
U., Goldring, M. B., Tillmann, B., and Paulsen, F. (2005). Human
?-defensin-3 mediates tissue remodelling processes in articular
cartilage by increasing metalloproteinases and reducing their
endogenous inhibitors. Arthritis Rheumatism 52,
1736-1745.
Huang, H., Held-Feindt,
J., Buhl, R., Mehdorn, H. M., Mentlein, R. (2005). Expression
of VEGF and its receptors in different brain tumors. Neurological
Res. 27, 371-377.
Gebhardt, M., Mentlein,
R., Schaudig, U., Pufe, T., Recker, K., Nolle, B., Al-Samir, K.,
Geerling, G., and Paulsen, F.P. (2005). Differential expression
of vascular endothelial growth factor implies the limbal origin
of pterygia. Ophthalmology 112, 1023-1030.
Mest, H.-J., and
Mentlein, R. (2005). Dipeptidyl peptidase inhibitors as new drugs
for the treatment of type 2 diabetes. Diabetologia 48,
616-620.
Mentlein, R. (2005).
Therapeutic assessment of glucagon-like peptide-1 agonists compared
with dipeptidyl peptidase IV inhibitors as potential antidiabetic
drugs. Expert Opin. Invest. Drugs 14, 57-64.
Mentlein, R., and
Pufe, T. (2005). New functions of angiogenic peptides in osteoarthritic
cartilage. Current Rheumatology Reviews 1, 37-43.
2004
Varoga, D., Pufe, T., Harder, J., Meyer-Hoffert, U., Mentlein,
R., Schröder, J.-M., Petersen, W. J., Tillmann, B. N., Proksch,
E., Goldring, M. B., and Paulsen, F. P. (2004). Production of
endogenous antibiotics in articular cartilage. Arthritis Rheumatism
50, 3526-3534
Schneider-Brachert W, Tchikov V, Winoto-Morbach S, Neumeyer J,
Jakob M, Held-Feindt J, Heinrich M, Merkel O,
Ehrenschwender M, Adam D, Mentlein R, Kabelitz D, Schütze
S (2004). Compartmentalization of TNF-Receptor-1
Signaling: Internalized TNF-Receptosomes as Death Signaling Vesicles.
Immunity 21, 415-428.
Pufe T, Petersen W J, Miosge N, Goldring M B, Mentlein R, Varoga
D J, Tillmann B N (2004). Endostatin / collagen
XVIII - an inhibitor of angiogenesis - is expressed in cartilage
and fibrocartilage. Matrix Biology 23, 267-276.
Becker, R., Pufe, T., Kulow, S., Giessmann, N., Neumann, W., Mentlein,
R., and Petersen, W. (2004). Expression of vascular endothelial
growth factor during healing of the meniscus in a rabbit model.
J. Bone Joint Surgery (British) 86, 1082-1087.
Pufe, T., Mentlein, R., Tsokos, M., Steven, P., Varoga, D., Goldring,
M.B., Tillmann, B. N., and Paulsen, F. P. (2004). VEGF expression
in adult permanent thyroid cartilage: Implications for lack of
cartilage. Bone 35, 543-552.
Mentlein R (2004). Cell surface peptidases. Int. Rev. Cytology
235, 165-213.
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout T A, Broadway
N, Hartmann D, Sedlacek R, Dietrich S,
Muetze B, Schuster B, Kallen K-J, Saftig P, Rose-John S, Ludwig
A (2004). The transmembrane CXC-chemokine
ligand 16 is induced by IFN-? and TNF-a and shed by the activity
of the disintegrin-like metalloproteinase ADAM10. J.
Immunol. 172, 6362-6372.
Mentlein R, Forstreuter F, Mehdorn H M, Held-Feindt J (2004).
Functional significance of vascular endothelial growth
factor receptor expression on human glioma cells. J. Neuro-Oncology
67, 9-18.
Petersen, W., Varoga, D., Zantop, T., Hassenpflug, J., Mentlein,
R., and Pufe, T. (2004). Cyclic strain influences the expression
of the vascular endothelial growth factor (VEGF) and the hypoxia
inducible factor 1 alpha (HIF-1alpha) in tendon fibroblasts. J.
Orthop. Res. 22, 847-853.
Pufe T, Harde V, Petersen W, Goldring M B, Tillmann B, Mentlein
R (2004). Vascular endothelial growth factor (VEGF)
induces matrix metalloproteinase expression in immortalized chondrocytes,
J. Pathol. 202, 367-374.
Petersen W, Pufe T, Zantop T, Tillmann, B, Tsokos M, Mentlein
R (2004) Expression of VEGFR-1 and VEGFR-2 in
degenerative Achilles tendons. Clin. Orthop. 420, 286-291.
Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, and Mentlein
R (2004) Mechanical overload induces VEGF in
cartilage discs via hypoxia-inducible factor (HIF). Amer. J. Pathol.
164, 185-192. |
|
