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Instiut Mitarbeiter Forschung Lehre Wissenschaftliche Sammlung Zentrum für Klinische Anatomie
[ AG Lüllmann ] [ AG Mentlein ] [ AG Schünke/Kurz ] [ AG Sievers/Lucius ] [ AG Wedel/Böttner ]
 
Arbeitsgruppe Wedel/Böttner English version
Prof. Dr. med. Thilo Wedel Prof. Dr. med. Thilo Wedel
Arzt, Facharzt für Anatomie
Tel: +49 431 880-2489
Fax: +49 431 880-2699
E-Mail:
t.wedel@anat.uni-kiel.de
Priv.-Doz. Dr. rer. nat. Martina Böttner Priv.-Doz.
Dr. rer. nat. Martina Böttner
Biologin
Tel: +49 431 880-2430
E-Mail:
m.boettner@anat.uni-kiel.de
(siehe auch "Zentrum für Klinische Anatomie")
Wissenschaftliche Mitarbeiter/in
Dr. rer. nat. Martina Barrenschee Dr. rer. nat. Martina Barrenschee
Dipl.-Biologin
Tel: +49 431 880-3087
E-Mail: m.barrenschee@anat.uni-kiel.de
Jonas Harde Jonas Harde
Arzt
Tel: +49 431 880-3087
E-Mail: j.harde@anat.uni-kiel.de
Dr. med. vet. Ines Hellwig Dr. med. vet. Ines Hellwig
Tierärztin
Tel: +49 431 880-3087
E-Mail: i.hellwig@anat.uni-kiel.de
   
Technische Mitarbeiter/in
Inka Geuring Inka Geurink
MTA
Tel: +49 431 880-3088
E-Mail: i.geurink@anat.uni-kiel.de
Miriam Lemmer Miriam Lemmer
MTA
Tel: +49 431 880-3791
E-Mail: m.lemmer@anat.uni-kiel.de
Karin Stengel Karin Stengel
MTA
Tel: +49 431 880-3791
E-Mail: k.stengel@anat.uni-kiel.de
   
Forschung

Neurogastroenterologie
Forschungsschwerpunkt ist das enterische Nervensystem (ENS). Das ENS ("Darmgehirn", "little brain of the gut") ist das größte Nervensystem außerhalb des Zentralnervensystems, das die peristaltischen Bewegungen und zahlreiche andere Funktionen (z.B. Resorption, Sekretion, Immunabwehr) des Magendarmtraktes steuert.
Unsere Untersuchungen über Entwicklung, Aufbau und Funktion des ENS sowie der sog. intestinalen Schrittmacherzellen (interstitielle Cajal-Zellen) leisten einen Beitrag, um die Ursachen für schwere gastrointestinale Passagestörungen zu klären. Besonderer Schwerpunkt liegt auf der histopathologischen Diagnostik von enterischen Neuro- und Myopathien bei verschiedenen funktionellen Magendarmerkrankungen (z.B. primäre chronische Obstipation, Megakolon, chronische intestinale Pseudoobstruktion, Reizdarmsyndrom, Divertikelkrankheit).
Unsere Arbeitsgruppe ist Mitglied einer internationalen Expertengruppe zur Etablierung von Leitlinien für die Klassifizierung sog. gastrointestinaler neuromuskulärer Pathologien.
Die interdisziplinären Forschungsansätze umfassen sowohl klinische als auch tierexperimentelle Projekte.

Wissenschaftliche Gesellschaften
Die Deutsche Gesellschaft für Neurogastroenterologie und Motilität (DGNM) dient dem Austausch und der Verbreitung medizinischer, diagnostischer und therapeutischer sowie wissenschaftlicher Ergebnisse und Informationen auf dem Gebiet der Neurogastroenterologie und Motilität. Unsere Arbeitsgruppe ist aktiv in der Gesellschaft engagiert (Vorstandsmitglied, 2006-2008).

Darüber hinaus sind wir beteiligt an der Erstellung von folgenden Leitlinien im Auftrag der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen (DGVS):

  • Reizdarmsyndrom
  • intestinale Motilitätsstörungen
  • Obstipation
  • Divertikelkrankheit
Links:
Deutsche Gesellschaft für Neurogastroenterologie und Motilität: http://www.neurogastro.de
Deutsche Gesellschaft für Verdauungs- und Stoffwechselerkrankungen: http://www.dgvs.de
European Society for Neurogastroenterology & Motility: http://www.neurogastroenterology.eu

Klinische Anatomie
Schwerpunkt der klinischen Anatomie liegt auf der Vermittlung von anatomischen Sachverhalten, die Voraussetzung für das Verständnis und den erfolgreichen Einsatz von Operationsverfahren und spezieller Operationsinstrumente bzw. -materialien sind.
Mit unterschiedlichsten Präparationstechniken werden anatomische Präparate hergestellt, die die Erprobung von chirurgischen Instrumenten und Implantaten sowie das Training innovativer Operationsmethoden erlauben. Die damit verbundenen wissenschaftlichen Projekte und das Angebot von Schulungs- und Fortbildungsveranstaltungen für Ärzte und Medizintechnologie-Firmen werden durch das Zentrum für Klinische Anatomie des Anatomischen Institutes organisiert.

Link: http://www.uni-kiel.de/anatomie/klinanat

 
Kooperationen

Christian-Albrechts-Universität zu Kiel:
Klinik für Neurologie, UKSH Campus Kiel:
- Prof. Dr. Deuschl
- PD Dr. Schneider
- Dr. Zorenkov
Klinik für Allgemeine Chirurgie und Thoraxchirurgie, UKSH Campus Kiel:
- Prof. Dr. Becker
- PD Dr. Egberts
Klinik für Innere Medzin I, UKSH Campus Kiel:
- Prof. Dr. Fritscher-Ravens
Institut für Physiologie, Christian-Albrechts Universität Kiel:
- PD Dr. Schmidtmayer
Städtisches Krankenhaus, Klinik für Chirurgie:
- Prof. Dr. Vogel

National:
Fachhochschule Kaiserslautern, Informatik und Mikrosystemtechnik:
- Prof. Dr. Schäfer
- Dr. Hagl
Praxis für Gastroenterologie und Ernährungsmedizin / Enddarmzentrum Mannheim:
- Prof. Dr. Krammer
- Prof. Dr. Herold
Abteilung für Endokrinologie, Universität Göttingen:
- Prof. Dr. Jarry

International:
Institut für Neurophysiolgie, Freie Universität Brüssel, Belgien:
- Prof. Dr. Vanderwinden
Klinik für Chirurgie, Universität Innsbruck, Österreich:
- Prof Dr. Aigner
Institut für Biologie, Universität Pelotas, Brasilien:
- Prof. Dr. Teixeira

 
Drittmittel
Deutsche Forschungsgemeinschaft
Forschungsförderung, Medizinische Fakultät, Universität zu Lübeck
Forschungsförderung, Medizinischen Fakultät, Christian-Albrechts-Universität zu Kiel
Fraunhofer Gesellschaft
United European Gastroenterology Federation
Forschungsförderung des Kinderkrankenhauses Köln
Industrie
Arbeitstechniken
  • konventionelle Histologie
  • Immunhistochemie
  • Darmwandschicht-Präparationen
  • Durchlicht- und Fluoreszenzmikroskopie
  • Morphometrie
  • Rasterelektronenmikroskopie
  • Transmissionselektronenmikroskopie
  • Quantitative Real-time RT-PCR
  • Low-Density-PCR-Arrays (microfluidic cards)
  • Western-Blot
  • In-Situ-Hybridisierung
  • Laser-Mikrodissektion
  • Organbad für glattmuskuläre Kontraktilitätsmessungen
  • Zellkultur

 
Publikationen
Original- und Übersichtsarbeiten: 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999

2012

Kayser O, Osmonov D, Harde J, Girolami G, Wedel T, Schäfer P (2012) Less invasive causal treatment of ejaculatory duct obstruction by balloon dilation: a case report, literature review and suggestion of a CT- or MRI-guided intervention. GMS German Medical Science 10:1-8

Wedel T, Barrenschee M, Hellwig I, Harde J, Böttner M (2012) Pathogenesis of diverticulosis and diverticular disease of the colon. Viszeralmedizin 28:164-70

Böttner M, Wedel T (2012) Abnormalities of neuromuscular anatomy in diverticular disease. Dig Dis 30:19-23

Böttner M, Zorenkov D, Hellwig I, Barrenschee M, Harde J, Fricke T, Deuschl G, Egberts JH, Becker T, Fritscher-Ravens A, Arlt A, Wedel T (2012) Expression pattern and localization of alpha-synuclein in the human enteric nervous system. Neurobiol Dis 48:474-80

Böttner M, Barrenschee M, Hellwig I, Harde J, Egberts JH, Becker T, Zorenkov D, Wedel T (2012) The enteric serotonergic system is altered in patients with diverticular disease. Gut 27

Fritscher-Ravens A, Milla P, Ellrichmann M, Hellwig I, Böttner M, Hadeler KG, Wedel T (2012) A novel endoscopic prototype device for gastric full-thickness biopsy for the histopathological diagnosis of GI neuromuscular pathology: in vivo porcine long-term survival study (with videos). Gastrointest Endosc 27

2011

Pahl R, Brunke G, Steubesand N, Schubert S, Böttner M, Wedel T, Jürgensen C, Hampe J, Schäfer H, Zeissig S, Schreiber S, Rosenstiel P, Reiss K, Arlt A (2011) IL-1β and ADAM17 are central regulators of β-defensin expression in Candida esophagitis. Am J Physiol Gastrointest Liver Physiol 300:G547-53

Knowles CH, Veress B, Kapur RP, Wedel T, Farrugia G, Vanderwinden JM, Geboes K, Smith VV, Martin JE, Lindberg G, Milla PJ, De Giorgio R (2011) Quantitation of cellular components of the enteric nervous system in the normal human gastrointestinal tract. Report on behalf of the Gastro 2009 International Working Group. Neurogastroentrol Motil 23:115-24

Petto C, Lesko S, Gäbel G, Böttner M, Wedel T, Kacza J, Pfannkuche H (2011) Establishment and characterisation of porcine colonic epithelial cells grown in primary culture. Cells Tissue Organs 194:457-68

Keller J, Wedel T, Seidl H, Kreis ME, Andresen V, Preiß JC, Layer P, van der Voort I (2011) S3-Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) zu Definition, Pathophysiologie, Diagnostik und Therapie intestinaler Motilitätsstörungen. Z Gastroenterol 49: 374-390

Stelzner S, Holm T, Moran BJ, Heald RJ, Witzigmann H, Zorenkov D, Wedel T (2011) Deep pelvic anatomy revisited for a description of crucial steps in extralevator abdominoperineal excision for rectal cancer. Dis Colon Rectum 54:947-57

Van Landeghem L, Chevalier J, Mahé MM, Wedel T, Urvil P, Derkinderen P, Savidge TC, Neunlist M (2011) Enteric glia promotes intestinal mucosal healing via activation of focal adhesion kinase and release of ProEGF. Am J Physiol Gastrointest Liver Physiol 300:G976-87

Zorenkov D, Otto S, Böttner B, Hedderich J, Vollrath O, Peter JP, Buhr H, Wedel T (2011) Morphological alterations of the enteric nervous system in young male patients with rectal prolapse. Int J Colorectal Dis 26:1483-91

2010

Böttner M, Leonhardt S, Wuttke W, Wedel T, Jarry H (2010) Expression of estrogen receptors in the hypothalamo-pituitary-ovarian axis in middle-aged rats after re-instatement of estrus cyclicity. Biogerontol 11:75-85 (IF=3,6)

Böttner M, Bär F, von Koschitzky H, Tafazzoli K, Roblick UJ, Bruch HP, Wedel T (2010) Laser microdissection as a new tool to investigate site-specific gene expression in enteric ganglia of the human intestine. Neurogastroenterol Motil 22:168-72

Wedel T, Büsing V, Heinrichs G, Nohroudi K, Bruch HP, Roblick U, Böttner M (2010): Diverticular disease is associated with an enteric neuropathy as revealed by morphometric analysis. Neurogastroenterol Motil 22:407-14

Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T (2010) The London classification of gastrointestinal neuromuscular pathology (GINMP): report on behalf of the Gastro 2009 International Working Group. Gut 59:882-7

2009
Teixeira AF, Kühnel W, Vives P, Wedel T (2009). Functional morphology of unguiculiform papillae of the reticular groove in the ruminant stomach. Ann Anat 191:469-76.

Knowles CH, De Giorgio R, Farrugia G, Geboes K, Gershon MD, Hutson J, Kapur RP, Lindberg G, Martin JE, Milla PJ, Smith VV, Veress B, Wedel T (2009) Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropatho 118:271-301

Neunlist M, Coron E, Flamant M, Aubert P, Wedel T, Pedron T, Letessier E, Galmiche JP, Sansonetti PJ (2009) Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon. PLoS ONE 4(3):e4713

Bär F, von Koschitzky H, Roblick U, Bruch HP, Schulze L, Sonnenborn U, Böttner M, Wedel T (2009): Cell-free supernatants of Escherichia coli Nissle 1917 (EcN) modulate human colonic motility - evidence from an in-vitro organ bath study (2009) Neurogastroenterol Motil 21:559-66

Spanholtz T, Maichle A, Niedworok C, Stoeckelhuber BM, Krüger S, Wedel T, Aach T, Middeler G, Hellwig-Bürgel T, Bader A, Krengel S, Müller OJ, Franz WM, Lindenmaier W, Machens HG (2009) Timing and targeting of cell-based VEGF(165) gene expression in ischemic tissue. J Surg Res 151:153-62

2008
Böttner M, Christoffel J, Wuttke W. (2008) Effects of long-term treatment with 8-prenylnaringenin and oral estradiol on the GH-IGF-1 axis and lipid metabolism in rats. J Endocrinol. 198: 395-401

Aigner F, Gruber H, Conrad F, Eder J, Wedel T, Zelger B, Engelhardt V, Lametschwandtner A, Wienert V, Böhler U, Margreiter R, Fritsch H: Revised morphology and hemodynamics of the anorectal vascular plexus: Impact on the course of hemorrhoidal disease. Int J Colorectal Dis 24:105-13

Jacobsen HC, Hakim SG, Lauer I, Dendorfer A, Wedel T, Sieg P (2008) Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca. J Craniomaxillofac Surg 36: 227-233

Harloff S, Hartwig D, Kasper K, Wedel T, Müller M, Geerling G (2008): Epitheliotrophic Capacity of Serum Eye Drops from Healthy Donors versus Serum from Immunosuppressed Patients with Rheumatoid Arthritis. Klin Monatsbl Augenheilkd 225: 200-206

Farke S, Paech A, Duchrow M, Bethge T, Wedel T, Lindner B, Roblick UJ, Bruch HP, Broll R (2008): Re-Sterilization of Surgical Polypropylene Meshes: Should it be Done? Research Journal of Medical Science 2: 7-12

2007
Böttner M, Leonhardt S, Wuttke W, Jarry H (2007) Changes of expression of genes related to the activity of the gonadotrophin-releasing hormone pulse generator in young versus middle-aged male rats. J Neuroendocrinol. 19:779-787.

Suzuki S, Gerhold LM, Böttner M, Rau SW, Dela Cruz C, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM (2007) Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. J Comp Neurol 500; 1064-1075.

Wedel T (2007) Functional Anatomy - Prerequisite for the understanding of defecation disorders. Chir Gastroenterol 23: 220-227

Wedel T, Böttner M, Krammer HJ (2007) The enteric nervous system and interstitial cells of Cajal. Changes in chronic constipation in adults. Pathologe 28:143-148

Schrader S, Wedel T, Kremling C, Laqua H, Geerling G (2007) Amniotic membrane as a carrier for lacrimal gland acinar cells. Graefes Arch Clin Exp Ophthalmol 245: 1699-704

Hernando-Harder AC, Franke A, Wedel T, Bottner M, Krammer HJ, Singer MV, Harder H (2007) Intestinal Gas Retention in Patients with Idiopathic Slow-Transit Constipation. Dig Dis Sci 52: 2667-75

Beutel J, Schroder C, von Hof K, Rades D, Kosmehl H, Wedel T, Sieg P, Geerling G, Hakim S (2007) Pharmacological prevention of radiation-induced dry eye - An experimental study in a rabbit model. Graefes Arch Clin Exp Ophthalmol 245: 1347-55

Neunlist M, Aubert P, Bonnaud S, van Landeghem L, Coron E, Wedel T, Naveilhan P, Ruhl A, Lardeux B, Savidge T, Paris F, Galmiche JP (2007) Enteric glia inhibits intestinal epithelial cell proliferation partly through a TGF-ß1-dependent pathway. Am J Physiol Gastrointest Liver Physiol 292: 231-241

Kohl M, Wedel T, Entenmann A, Stuttmann J, Bendiks M, Loff S, Koster S, Ortfeld S, Bos I (2007) Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model. J Pediatr Gastroenterol Nutr 44: 237-44

2006
Trauzold A, Siegmund D, Schniewind B, Sipos B, Egberts J, Zorenkov D, Emme D, Röder C, Kalthoff H, Wajant H (2006) TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene 25:7434-9.

von Schassen C, Fester L, Prange-Kiel J, Lohse C, Huber C, Böttner M, Rune GM (2006) Oestrogen synthesis in the hippocampus: role in axon outgrowth. J Neuroendcrinol 18: 847-856.

Böttner M, Wuttke W. (2006) Chronic treatment with physiological doses of estradiol affects the GH-IGF-1 axis and fat metabolism in young and middle-aged ovariectomized rats. Biogerontology 7: 91-100.

Böttner M, Christoffel J, Jarry H, Wuttke W. (2006) Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats. J Endocrinol 189:77-88.

Fester L, Ribeiro-Gouveia V., Prange-Kiel J, von Schassen C, Böttner M, Jarry H, Rune GM (2006) Proliferation and apoptosis of hippocampal granule cells require local oestrogen synthesisl J. Neurochem 97:1136-1144.

Böttner M, Christoffel J, Rimoldi G, Wuttke W. (2006) Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on the pituitary-thyroid axis. Exp Clin Endocrinol Diabetes 114:82-90.

Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki G, Gerhold LM, Böttner M, Dubal SB, Merchanthaler I, Kindy MS, Wise PM. (2006) Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death. Endocrinology 147: 3076-3084.

Kruse C, Kajahn J, Petschnik AE, Maass A, Klink E, Rapoport DH, Wedel T (2006) Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures. Ann Anat 188: 503-517

Schrader S, Wedel T, Moll R, Geerling G (2006) Combination of serum eye drops with hydrogel bandage contact lenses in the treatment of persistent epithelial defects. Graefes Arch Clin Exp Ophthalmol 244: 1345-1349

Wedel T (2006) Der Beckenboden: Anatomische Grundlagen. Viszeralchirurgie 41: 153-162

Wedel T, van Eys G, Glénisson W, Waltregny D, Vanderwinden JM (2006) Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Neurogastroenterol Motil 18: 526-538

Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G (2006) Corneal epitheliotrophic capacity of three different blood-derived preparations. Invest Ophtamol Vis Sci 47: 2438-2444

Nishino T, Wedel T, Schmitt O, Bühlmeyer K, Schönfelder M, Hirtreiter C, Schulz T, Kühnel W, Michna H (2006) The xenoestrogen bisphenol A in the Hershberger assay: androgen receptor regulation and morphometrical reactions indicate no major effects. J Steroid Biochem Mol Biol 98: 155-163

Hakim S, Schroder C, Geerling G, Lauer I, Wedel T, Kosmehl H, Driemel O, Jacobsen HC, Trenkle T, Hermes D, Sieg (2006) Early and late immunohistochemical and ultrastructural changes associated with functional impairment of the lacrimal gland following external beam radiation. Int J Exp Pathol 87: 65-71

2005
Böttner M, Dubal DB, Rau SW, Suzuki S, Wise PM. (2005) Stroke injury in rats causes an increase in activin A gene expression which is unaffected by estradiol treatment. J Neuroendocrinol. 18: 97-103.

Böttner M, Wuttke W (2005). Chronic treatment with low doses of estradiol affects pituitary and thyroid function in middle-aged ovariectomized rats. Biogerontology 6: 261-269.

Hakim S, Kosmehl H, Lauer I, Nadrowitz R, Wedel T, Sieg P (2005) A comparative study on the protection profile of lidocaine, amifostine and pilocarpine on the parotid gland during radiotherapy. Cancer Res 65: 10486-10493

Niessen P, Rensen S, van Deursen J, De Man J, De Laet A, Vanderwinden JM, Wedel T, Baker D, Doevendans P, Hofker M, Gijbels M, van Eys G (2005) Smoothelin-A is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology 129: 1592-1601

de Lorijn F, de Jonge WJ, Wedel T, Vanderwinden JM, Benninga MA, Boeckxstaens GE (2005) Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex. Gut 54: 1107-13

Tafazzoli K, Soost K, Wessel L, Wedel T (2005) Topographic pecularities of the submucous plexus in the human anorectum - consequences for histopathologic evaluation of rectal biopsies. Eur J Pediatr Surg 15: 159-63

Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G (2005) An optimised protocol for the production of autologous serum eyedrops. Graefes Arch Clin Exp Ophthalmol 243: 706-714

Wedel T (2005) Obstipation. Coloproctology 27: 204-208

Sayk F, Bos I, Schubert U, Wedel T, Sievers HH (2005) Histopathologic findings in a novel decellularized pulmonary homograft: an autopsy study. Ann Thorac Surg 79: 1755-8

Tiedemann K, Sasaki T, Gustafsson E, Göhring W, Bätge B, Notbohm H, Wedel T, Schlötzer-Schrehardt U, Reinhardt DP (2005). Microfibrils at basement membrane zones interact with perlecan via fibrillin-1. J Biol Chem 25: 11404-12

Hartwig D, Herminghaus D, Wedel F, Schlenke P, Geerling G (2005) Topical treatment of ocular surface defects: Comparison of the epitheliotrophic capacity of fresh frozen plasma and serum on corneal epithelial cells in an in-vitro cell culture model. Transfusion Med 15: 107-113

Most P, Boerries M, Eicher C, Schweda C, Wedel T, Söllner S, Katus HA, Remppis A, Aebi U, Koch WJ, Schoenenberger CA (2005). Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes. J Cell Science 118:421-31

2004
Bruch HP, Schwandner O, Krammer HJ, Söllner S, Wedel T (2004) Ursachen und Therapie des Megakolons beim Erwachsenen. Chir Praxis 62, 605-617

Hartwig D, Harloff S, Liu L, Schlenke P, Wedel T, Geerling G (2004) Epitheliotrophic capacity of a growth factor preparation produced from platelet concentrates on corneal epithelial cells: A potential agent for the treatment of ocular surface defects? Transfusion 44: 1724-31

Birth M, Wedel T, Hildebrand P, Bruch HP, Kruse C (2004) Isolation, culture and characterization of adult pluripotent stem cells of pancreas. Chir Forum 33: 405-407

Herminghaus P, Hartwig D, Wedel T, Dibbelt L, Geerling G (2004) Epitheliotrophic capacity of serum and plasma eyedrops. Influence of centrifugation. Ophtalmologe 101: 998-1005

Holland-Cunz S, Bainczyk S, Hagl C, Wink E., Wedel T, Back W, Schäfer KH (2004) Three dimensional co-culture model of enterocytes and primary enteric neuronal tissue. Pediatr Surg Internat 20: 233-7

Nishino T, Wedel T, Schmitt O, Bühlmeyer K, Schönfelder M, Hirtreiter C, Schulz T, Kühnel W, Michna H (2004) Androgen-dependent morphology of prostate and seminal vesicles in the Hershberger Assay: Evaluation of immunohistochemical and morphometric parameters. Ann Anat 186: 247-253

Kruse C, Birth M, Rohwedel J, Assmuth K, Göpel A, Wedel T (2004) Pluripotency of adult stem cells derived from human and rat pancreas. Appl Phys A

2003
Rau SW, Dubal DB, Böttner M, Gerhold LM, Wise PM. (2003) Estradiol attenuates programmed cell death after stroke-like injury. J Neurosci. 23:11420-11426.

Rau SW, Dubal DB, Böttner M, Wise PM. (2003) Estradiol differentially regulates c-Fos after focal cerebral ischemia. J Neurosci. 23:10487-10494.

Wulf J, Busch LC, Wedel T (2003) Anatomie der Leber - vom Orakel zum dreidimensionalen Modell. Focus MUL 20: 237-240

Holland-Cunz S, Krammer HJ, Süss A, Tafazzoli K, Wedel T (2003) Molecular genetics of colorectal motility disorders. Eur J Pediatr Surg 13, 146-151

Wedel T, Tafazzoli K, Söllner S, Krammer HJ, Holschneider AM (2003) Mitochondrial myopathy (complex I deficiency) associated with chronic intestinal pseudoobstruction. Eur J Pediatr Surg 13, 201-205

2002
Wise PM, Smith MJ, Dubal DB, Wilson ME, Rau SW, Cashion AB, Böttner M, Rosewell KL. (2002) Neuroendocrine modulation and repercussions of female reproductive aging. Recent Prog Horm Res. 57:235-256. Review.

Krammer HJ, Süss A, Singer MV, Wedel T (2002) Neurogastroenterology - From the Basics to the Clinics. R J Gastroenterology 11, 313-319

Wedel T, Spiegler J, Söllner S, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ (2002) Interstitial cells of Cajal and the enteric nervous system are concomitantly altered in patients with slow-transit constipation and megacolon. Gastroenterology 123: 1459-1467

Hakim S, Kossmehll H, Lauer I, Nadrowitz R, Wedel T, Sieg P (2002). The role of myoepithelial cells in the short-term radiogenic impairment of salivary glands. An immunohistochemical, ultrastructural and scintigraphic study. Anticancer Res 22: 4121-4128

Von Boyen GBT, Krammer HJ, Dembowski C, Ehrenreich H, Wedel T (2002) Abnormalities of the enteric nervous system in heterozygous endothelin B-receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia. Gut 51: 414-419

Wedel T, Roblick UJ, Ott V, Eggers R, Schiedeck THK, Krammer HJ, Bruch HP (2002) Oligoneuronal hypoganglionosis in patients with idiopathic slow transit constipation. Dis Colon Rectum 45: 54-62

2001
Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M, Rosewell KL. (2001) Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Res Brain Res Rev. 37(1-3):313-319. Review.

Schober A, Böttner M, Strelau J, Kinscherf R, Bonaterra GA, Barth M, Schilling L, Fairlie WD, Breit SN, Unsicker K. (2001) Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain. J Comp Neurol. 439(1):32-45.

Roosen A, Schober A, Strelau J, Böttner M, Faulhaber J, Bendner G, McIlwrath SL, Seller H, Ehmke H, Lewin GR, Unsicker K. (2001) Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation. J Neurosci. 21(9):3073-3084.

Teixera AF, Krammer HJ, Kühnel W, Wedel T (2001) Structural organisation of the enteric nervous system in the cattle esophagus revealed by wholemount immunohistochemistry. It J Anat Embryol 106: 313-321

2000
Strelau J, Böttner M, Lingor P, Suter-Crazzolara C, Galter D, Jaszai J, Sullivan A, Schober A, Krieglstein K, Unsicker K. (2000) GDF-15/MIC-1 a novel member of the TGF-beta superfamily.J Neural Transm Suppl. (60):273-276. Review.

Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M. (2000) Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology. 142(3):969-973. Review.

Böttner M, Krieglstein K, Unsicker K. (2000) The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions. J Neurochem. 75(6):2227-2240. Review.

Strelau J, Sullivan A, Böttner M, Lingor P, Falkenstein E, Suter-Crazzolara C, Galter D, Jaszai J, Krieglstein K, Unsicker K. (2000) Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. J Neurosci. 20(23):8597-8603.

Wedel T, Spiegler J, Ott V, Kühnel W, Sigge W, Reusche E, Krammer HJ (2000) Intestinale Innervationsstörungen bei chronischer Obstipation. Focus MUL 17: 233-240

Wedel T (2000) Mögliche Ursachen der chronischen Obstipation. Zentralbl Chir 125:564-566

Wedel T, Roblick UJ, Schiedeck THK, Bruch HP, Reusche E (2000) Erworbene Hypoganglionose als Folge einer enterischen Ganglionitis. Focus MUL 17: 246-248

1999
Wedel T, Roblick UJ, Quoß J, Schiedeck THK, Bruch HP, Krammer HJ (1999) Intestinale Innervationsstörungen: Anatomische Grundlagen und Diagnostik. Coloproctology 21: 101-108

Wedel T, Eggers R, Gleiß J, Schiedeck THK, Bruch HP, Sigge W, Krammer HJ (1999) Das enterische Nervensystem: Von der Anatomie zur Klinik. Focus MUL 16: 22-30

Böttner M, Laaff M, Schechinger B, Rappold G, Unsicker K, Suter-Crazzolara C. (1999) Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Gene. 237(1):105-111.

Böttner M, Suter-Crazzolara C, Schober A, Unsicker K. (1999) Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res. 297(1):103-110.

Galter D, Böttner M, Krieglstein K, Schomig E, Unsicker K. (1999) Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins. Eur J Neurosci. 11(7):2444-2452.

Galter D, Böttner M, Unsicker K. (1999) Developmental regulation of the serotonergic transmitter phenotype in rostral and caudal raphe neurons by transforming growth factor-betas. J Neurosci Res. 56(5):531-538.

Leffler A, Wedel T, Busch LC (1999) Congenital colonic hypoganglionosis in murine trisomy 16 - a model for Down´s syndrome. Eur J Pediatr Surg 9: 381-388

Wedel T, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ (1999) Ist die Divertikelkrankheit mit intestinalen Innervationsstörungen assoziiert? Viszeralchirurgie 34: 307-311

Wedel T, Roblick UJ, Gleiß J, Ott V, Eggers R, Kühnel W, Krammer HJ (1999) Intestinale Innervationsstörungen als mögliche Ursache der chronischen Obstipation. Zentralbl Chir 124: 796-803

Wedel T, Roblick UJ, Gleiß J, Schiedeck THK, Bruch HP, Kühnel W, Krammer HJ (1999) Organization of the enteric nervous system in the human colon demonstrated by wholemount immunohistochemistry with special reference to the submucous plexus. Ann Anat 181: 327-337

Michailova K, Wassilev W, Wedel T (1999) Scanning and transmission electron microscopic study of visceral and parietal peritoneal regions in the rat. Ann Anat 181: 253-260

Entenmann A, Wedel T, Kolbert G, Bruch HP, Kühnel W (1999) Morphologische Untersuchungen zur alloplastischen Deckung von Bauchwanddefekten. Focus MUL 16: 148-154

Entenmann A, Wedel T, Kolbert G, Kühnel W, Bruch HP (1999) Scanning electron microscopy study including maceration techniques of an absorbable alloplastic implant designed for the reconstruction of ventral abdominal wall defects. Ann Anat 181: 237-245

Wedel T, Holschneider AM, Krammer HJ, Kühnel W (1999) Ultrastructural features of nerve fascicles and basal lamina abnormalities in Hirschsprung´s disease. Eur J Ped Surg 9: 75-82

Buchbeiträge / Bücher: 2012 2010 2009 2008 2006 2005 2002 2001 2000 1999 1995

2012
Wedel T (2012) Anatomy of the rectum, anal canal and pelvic floor. In Moran B, Heald RJ (eds.) Manual of Total Mesorectal Excision. Hodder Arnold´s Publishers (im Druck)

2010
Wedel T, Krammer HJ (2010) Anatomische und physiologische Grundlagen der gastrointestinalen Motilität. In Buchmann P, Degen L P (eds) Chronische Bauchbeschwerden. Verlag Hans Huber, Bern, Göttingen, Toronto

Wedel T, Böttner M (2010) Pathogenese der Divertikelkrankheit. In Kruis W (ed) Divertikelkrankheit. Verlag Uni-Med. Bremen, London, Boston

Wedel T, Pauli F (2010) Anatomische und chirurgische Grundlagen zur Netzrekonstruktion des Beckenbodens. Thieme Verlag.

2009
Wedel T, Krammer HJ (2009) Neuroanatomie und Neuropathologie. In Jost W (ed) Neurokoloproktologie - Neurologie des Beckenbodens, 2. Auflage. Verlag Uni-Med. Bremen, London, Boston

Wedel T (2009) Ätiologie der chronischen Obstipation. In Krammer HJ, Herold A (ed) Chronische Obstipation in der Praxis und Klinik, Verlag Uni-Med. Bremen, London, Boston

2008
Wedel T (2008) Anatomy of the Colon, Rectum, Anus and Pelvic Floor. In Herold A, Lehur PA, Matzel KE, O´Connell PR (eds) European Manual of Medicine: Coloproctology. Springer.

Wedel T, Krammer HJ, Holschneider AM (2008) Electron microscopical studies of Hirschsprung´s disease. In Holschneider AM, Puri P (eds) Hirschsprung´s disease and allied disorders. 3. edition. Springer.

2006
Krammer HJ, Schlieger F, Wedel T (2006) Intestinal comorbidity: diverticular disease and chronic inflammatory bowel disease. In Forbes, Jauch, Kruis, Wexner (eds) Diverticular Disease: Emerging Evidence in a common condition. Springer, pp 69-75

Wedel T, Böttner M, Krammer HJ (2006) Pathogenesis of Diverticular Disease: Enteric neuropathy. In Forbes, Jauch, Kruis, Wexner (eds) Diverticular Disease: Emerging Evidence in a common condition. Springer, pp 17-23

2005
Wedel T, Krammer HJ (2005) Neuroanatomie und Physiologie des Kolons. In Jost W (ed) Neurologie des Beckenbodens - Neuroproktologie, 1. Auflage. Verlag Uni-Med. Bremen, London, Boston

2002
Wedel T, Krammer HJ (2002) Kolorektale Innervationsstörungen. In Buchmann P (ed) Lehrbuch der Proktologie, 4. Auflage. Verlag Hans Huber. Bern, Göttingen, Toronto, Seattle, pp 180-189

2001
Wedel T, Roblick UJ, Schiedeck THK, Schrader S, von Koschitzky H, Bruch HP, Krammer HJ. (2001) Ist die Divertikelkrankheit mit intestinalen Innervationsstörungen assoziiert? In Schumpelick V, Kasperk R (eds) Divertikulitis - Eine Standortbestimmung. Springer. Berlin, Heidelberg, New York, pp 38-43

Krammer HJ, Wedel T, Schäfer KH, Schiedeck THK, Roblick UJ, Bruch HP (2001) Intrinsic innervation and innervational abnormalities of the colorectum - from morphology to molecular genetics. In Bruch HP, Frühmorgen P (eds) Non-Neoplastic Diseases of the Anorectum - An Interdisciplinary Approach. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 26-37

2000
Krieger F, Wedel T, Meier-Ruge W, Singer MV, Krammer HJ (2000) Immunohistochemical evaluation of the cholinergic, nitrergic and peptidergic innervation of intestinal neuronal dysplasia (IND) in children. The architectural heterogeneity of the enteric nervous system in the forestomach of ruminants. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 504-510

Schneider GBT, Wedel T, Dembowski C, Ehrenreich J, Singer MV, Krammer HJ (2000) Three-dimensional architecture of the enteric nervous system in homozygous endothelin-B-receptor (ETB) deficient (spotting lethal) rats compared to patients with Hirschsprung´s disease. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 485-492

Wedel T, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ (2000) The enteric nervous system of the human colon demonstrated by wholemount immunohistochemistry: normal structure and histopathlogy in chronic intestinal motility disorders. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 441-453

Teixeira AF, Wedel T, Kühnel W, Krammer HJ (2000) The architectural heterogeneity of the enteric nervous system in the forestomach of ruminants. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 107-115

Leffler A, Wedel T, Busch LC (2000) Abnormalities of the enteric nervous system in an animal model for Down´s Syndrome. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 496-503

Wedel T, Krammer HJ, Holschneider AM (2000) Electron microscopical studies of Hirschsprung´s disease. In Holschneider AM, Puri P (eds) Hirschsprung´s disease and allied disorders. Harwood Academic Publishers. Amsterdam, pp 280-290

1999
Krammer HJ, Wedel T, Singer MV (1999) Kolorektale Innervation und Innervationsstörungen - von der Morphologie zur Molekulargenetik. In Kirchner T, Lembcke B, Kist M (eds) Ökosystem Darm VIII. Springer. Berlin, pp 215-232

1998
Krammer HJ, Wedel T, Krieger F, Wessel L, Meier-Ruge W, Singer MV (1998) Evaluation of the intrinsic nervous system in human colonic biopsies by immunohistochemistry for neuronal and glial proteins. In Holtmann G, Goebell H, Talley NJ (eds) Functional and irritable bowel syndrom: Concepts and controversies. Kluwer Academic Publishers. Dordrecht, Boston, Londen, pp 60-66

1995
Freund U, Krammer HJ, Sigge W, Wedel T, Kühnel W (1995) Nerves and endocrine cells in the neomucosa. In Singer MV, Ziegler R, Rohr G (eds) Gastrointestinal Tract and Endocrine System. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 89-92