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Geilfus, C.-M., Ober, D., Eichacker, L. A., Mühling, K. H., Zörb, C. (2015)

Down regulation of ZmEXPB6 is correlated with salt mediated growth reduction in leaves of Zea mays L.

J. Biol. Chem., in press


Irmer, S., Podzun, N., Langel, D., Heidemann, F., Kaltenegger, E., Schemmerling, B., Geilfus, C.-M., Zörb, C., Ober, D. (2015)

A new aspect of plant-rhizobia interaction - alkaloid biosynthesis in Crotalaria depends on nodulation.

Proc. Natl. Acad. Sci. U. S. A., in press


Kaltenegger, E., Eich, E., Ober, D. (2013)

Evolution of homospermidine synthase in the Convolvulaceae – a story of gene duplication, gene loss, and periods of various selection pressures.

Plant Cell, 25: 1213-1227 [PubMed ][][OpenAccess ]


Niemüller, D., Reimann, A., Ober, D. (2012)

Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the Boraginales.

Plant Physiology, 159: 920-929 [PubMed ][DOI:10.1104/pp.112.195024 ][OpenAccess ]


Wang, L., Beuerle, T., Timbilla, J., Ober, D. (2012)

Independent recruitment of a flavin-dependent monooxygenase for safe accumulation of sequestered pyrrolizidine alkaloids in grasshoppers and moths.

PLoS ONE 7: e31796  [PubMed](DOI:10.1371/journal.pone.0031796)


Langel, D., Ober, D. (2011)

Evolutionary recruitment of a flavin-dependent monooxygenase for stabilization of sequestered pyrrolizidine alkaloids in arctiids.

Phytochemistry, 72: 1576-1584 [PubMed] (DOI: 10.1016/j.phytochem.2010.12.014)


Langel, D., Ober, D., Pelser, P. (2010)

The evolution of pyrrolizidine alkaloid biosynthesis and the diversity in the Senecioneae.

Phytochemistry Reviews, 10(1): 3-74 (DOI: 10.1007/s11101-010-9184-y)


Sehlmeyer, S., Wang, L., Langel, D., Heckel, D.G., Mohagheghi, H., Petschenka, G., Ober, D. (2010)

Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (Lepidoptera).

PLoS ONE 5(5): e10435 [PubMed] (DOI:doi:10.1371/journal.pone.0010435)


Ober, D. (2010)

Gene duplications and the time thereafter - examples from plant secondary metabolism.

Plant Biology,12: 570-577 [PubMed]


Abdelhady, M. I. S., Beuerle, T., Ober, D. (2009)

Homospermidine in transgenic tobacco results in considerably reduced spermidine levels but is not converted to pyrrolizidine alkaloid precursors.

Plant Molecular Biology, 71: 145-155 [PubMed]


Ober, D., Kaltenegger, E. (2009)

Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism.

Phytochemistry, 70: 1687-1695 [PubMed]


Nurhayati; N., Gondé, D., Ober, D. (2009)

Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: Identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes.

Phytochemistry, 70: 508-516 [PubMed]


Bilger, W., Dauborn, B., Ober, D. (2009)

Sekundärstoffwechsel.

In: Taschenbuch Biologie - Botanik, Munk, K. (Ed.),  Thieme , Stuttgart: 359-401 [Additional Information]


Anke, S., Gondé, D., Kaltenegger, E., Hänsch, R., Theuring, C., Ober, D. (2008)

Pyrrolizidine alkaloid biosynthesis in Phalaenopsis orchids: Developmental expression of alkaloid-specific homospermidine synthase in root tips and young flower buds.

Plant Physiology 148 : 751-760 [PubMed]


Michalski, C., Mohagheghi, H., Nimtz, M., Pasteels, J., Ober, D. (2008)

Salicyl alcohol oxidase of the chemical defense secretion of two chrysomelid leaf beetles: Molecular and functional characterization of two new members of the GMC oxidoreductase gene family.

J. Biol. Chem. 283 : 19219-19228 [PubMed]


Hartmann, T. , Ober, D. (2008)

Defense by Pyrrolizidine Alkaloids: Developed by Plants and Recruited by Insects. 

In: "Induced Plant Resistance to Herbivory", Schaller, A. (Ed.), Springer Science+Business Media B.V.: 213-231 [Additional Information]


Ober, D. (2007)

Keine Wunderwaffe aus dem Regenwald!

In: "Vorbild Natur. Stand und Perspektiven der Naturstoff-Forschung in Deutschland", DECHEMA, Frankfurt/M. [pdf]  


Ober, D. (2007)

Pflanzenextrakte als Arzneimittel?

In: "Vorbild Natur. Stand und Perspektiven der Naturstoff-Forschung in Deutschland", DECHEMA, Frankfurt/M. [pdf]  


Frölich, C., Ober, D., Hartmann, T. (2007)

Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species

Phytochemistry 68 : 1026-1037 [PubMed]


Frölich, C., Hartmann, T., Ober, D. (2006)

Tissue distribution and biosynthesis of 1,2-saturated pyrrolizidine alkaloids in Phalaenopsis hybrides (Orchidaceae).

Phytochemistry 67 : 1493-1502 [PubMed]  


Ober, D. (2005)

Seeing double – gene duplication and diversification in plant secondary metabolism.

Trends Plant Sci. 10 : 444-449 [PubMed]


Nurhayati, N., Ober, D. (2005)

Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: does Crotalaria possess a functional HSS that still has DHS activity?

Phytochemistry 66 : 1346-1357 [PubMed]


Anke, S., Niemüller, D., Moll, S., Hänsch, R., Ober, D. (2004)

Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae: Evidence from differential tissue expression of homospermidine synthase.

Plant Physiology 136 : 4037-4047 [PubMed]


Reimann, A., Nurhayati, N., Backenköhler, A., and Ober, D. (2004)

Repeated evolution of the pyrrolizidine-mediated defense system in separate angiosperm lineages.

Plant Cell 16 : 2772-2784 [PubMed]


Ober, D. (2003)

Chemical ecology of alkaloids exemplified with the pyrrolizidines.

Recent Adv. Phytochem. (J. T. Romeo et al., eds., Pergamon, Amsterdam) 37, : 203-230 [Request Reprint]


Ober, D., Harms, R., Witte, L., Hartmann, T. (2003)

Molecular evolution by change of function: Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein.

J. Biol. Chem. 278 : 12805-12812 [PubMed]


Ober, D., Gibas, L., Witte, L., Hartmann, T. (2003)

Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase.

Phytochemistry 62 : 339-344 [PubMed]


Hartmann,T., Ober,D. (2003)

Der pflanzliche Sekundärstoffwechsel: Biologische Notwendigkeit und pharmazeutischer Nutzen.

Carolo-Wilhelmina: Forschungsmagazin der Technischen Universität Braunschweig 38 : 26-32 [pdf ]


Moll, S. ,Anke, S., Kahmann, U., Hansch, R., Hartmann, T., Ober, D. (2002)

Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase.

Plant Physiology 130 : 47-57 [PubMed]


Naumann, C., Hartmann, T., Ober, D. (2002)

Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae.

Proc. Natl. Acad. Sci. U. S. A. 99 : 6085-90 [PubMed]


Ober, D. (2001)

Warum gibt es Gift- und Arzneipflanzen? Die Evolution des pflanzlichen Sekundärstoffwechsels am Beispiel der Pyrrolizidin-Alkaloide.

Deutsche Apotheker Zeitung 141 : 2127-2131


Ober, D., Hartmann, T. (2000)

Phylogenetic origin of a secondary pathway: The case of pyrrolizidine alkaloids.

Plant Mol. Biol. 44 : 445-450 [PubMed]


Ober, D., Harms, R., Hartmann, T. (2000)

Cloning and expression of homospermidine synthase from Senecio vulgaris: A revision.

Phytochemistry 55 : 305-309 [PubMed]


Hartmann, T., Ober, D. (2000)

Biosynthesis and metabolism of pyrrolizidine alkaloids in plants and specialized insect herbivores.

Top. Curr. Chem. 209 : 207-244


Ober, D., Hartmann, T. (1999)

Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase.

Proc. Natl. Acad. Sci. U. S. A. 96 : 14777-14782 [PubMed]


Ober, D., Hartmann, T. (1999)

Deoxyhypusine synthase from tobacco: cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity.

J. Biol. Chem. 274 : 32040-32047 [PubMed]


Tholl, D., Ober, D., Martin, W., Kellermann, J., Hartmann, T. (1996)

Purification, molecular cloning and expression in Escherichia coli of homospermidine synthase from Rhodopseudomonas viridis.

Eur. J. Biochem. 240 : 373-379 [PubMed]


Ober, D.,Tholl, D.,Martin, W.,Hartmann, T. (1996)

Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli.

J. Gen. Appl. Microbiol. 42 : 411-419


Böttcher, F., Ober, D., Hartmann, T. (1994)

Biosynthesis of pyrrolizidine alkaloids: Putrescine and spermidine are essentail substrates of enzymatic homospermidine formation.

Can. J. Chem. 72 : 80-85

 
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