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Kaltenegger, E., Eich, E., Ober, D. (2013)

Evolution of homospermidine synthase in the Convolvulaceae – a story of gene duplication, gene loss, and periods of various selection pressures.

Plant Cell, 25: 1213-1227 [PubMed ][][OpenAccess ]


Niemüller, D., Reimann, A., Ober, D. (2012)

Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the Boraginales.

Plant Physiology, 159: 920-929 [PubMed ][DOI:10.1104/pp.112.195024 ][OpenAccess ]


Wang, L., Beuerle, T., Timbilla, J., Ober, D. (2012)

Independent recruitment of a flavin-dependent monooxygenase for safe accumulation of sequestered pyrrolizidine alkaloids in grasshoppers and moths.

PLoS ONE 7: e31796  [PubMed](DOI:10.1371/journal.pone.0031796)


Langel, D., Ober, D. (2011)

Evolutionary recruitment of a flavin-dependent monooxygenase for stabilization of sequestered pyrrolizidine alkaloids in arctiids.

Phytochemistry, 72: 1576-1584 [PubMed] (DOI: 10.1016/j.phytochem.2010.12.014)


Langel, D., Ober, D., Pelser, P. (2010)

The evolution of pyrrolizidine alkaloid biosynthesis and the diversity in the Senecioneae.

Phytochemistry Reviews, 10(1): 3-74 (DOI: 10.1007/s11101-010-9184-y)


Sehlmeyer, S., Wang, L., Langel, D., Heckel, D.G., Mohagheghi, H., Petschenka, G., Ober, D. (2010)

Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (Lepidoptera).

PLoS ONE 5(5): e10435 [PubMed] (DOI:doi:10.1371/journal.pone.0010435)


Ober, D. (2010)

Gene duplications and the time thereafter - examples from plant secondary metabolism.

Plant Biology,12: 570-577 [PubMed]


Abdelhady, M. I. S., Beuerle, T., Ober, D. (2009)

Homospermidine in transgenic tobacco results in considerably reduced spermidine levels but is not converted to pyrrolizidine alkaloid precursors.

Plant Molecular Biology, 71: 145-155 [PubMed]


Ober, D., Kaltenegger, E. (2009)

Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism.

Phytochemistry, 70: 1687-1695 [PubMed]


Nurhayati; N., Gondé, D., Ober, D. (2009)

Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: Identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes.

Phytochemistry, 70: 508-516 [PubMed]


Bilger, W., Dauborn, B., Ober, D. (2009)

Sekundärstoffwechsel.

In: Taschenbuch Biologie - Botanik, Munk, K. (Ed.),  Thieme , Stuttgart: 359-401 [Additional Information]


Anke, S., Gondé, D., Kaltenegger, E., Hänsch, R., Theuring, C., Ober, D. (2008)

Pyrrolizidine alkaloid biosynthesis in Phalaenopsis orchids: Developmental expression of alkaloid-specific homospermidine synthase in root tips and young flower buds.

Plant Physiology 148 : 751-760 [PubMed]


Michalski, C., Mohagheghi, H., Nimtz, M., Pasteels, J., Ober, D. (2008)

Salicyl alcohol oxidase of the chemical defense secretion of two chrysomelid leaf beetles: Molecular and functional characterization of two new members of the GMC oxidoreductase gene family.

J. Biol. Chem. 283 : 19219-19228 [PubMed]


Hartmann, T. , Ober, D. (2008)

Defense by Pyrrolizidine Alkaloids: Developed by Plants and Recruited by Insects. 

In: "Induced Plant Resistance to Herbivory", Schaller, A. (Ed.), Springer Science+Business Media B.V.: 213-231 [Additional Information]


Ober, D. (2007)

Keine Wunderwaffe aus dem Regenwald!

In: "Vorbild Natur. Stand und Perspektiven der Naturstoff-Forschung in Deutschland", DECHEMA, Frankfurt/M. [pdf]  


Ober, D. (2007)

Pflanzenextrakte als Arzneimittel?

In: "Vorbild Natur. Stand und Perspektiven der Naturstoff-Forschung in Deutschland", DECHEMA, Frankfurt/M. [pdf]  


Frölich, C., Ober, D., Hartmann, T. (2007)

Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species

Phytochemistry 68 : 1026-1037 [PubMed]


Frölich, C., Hartmann, T., Ober, D. (2006)

Tissue distribution and biosynthesis of 1,2-saturated pyrrolizidine alkaloids in Phalaenopsis hybrides (Orchidaceae).

Phytochemistry 67 : 1493-1502 [PubMed]  


Ober, D. (2005)

Seeing double – gene duplication and diversification in plant secondary metabolism.

Trends Plant Sci. 10 : 444-449 [PubMed]


Nurhayati, N., Ober, D. (2005)

Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: does Crotalaria possess a functional HSS that still has DHS activity?

Phytochemistry 66 : 1346-1357 [PubMed]


Anke, S., Niemüller, D., Moll, S., Hänsch, R., Ober, D. (2004)

Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae: Evidence from differential tissue expression of homospermidine synthase.

Plant Physiology 136 : 4037-4047 [PubMed]


Reimann, A., Nurhayati, N., Backenköhler, A., and Ober, D. (2004)

Repeated evolution of the pyrrolizidine-mediated defense system in separate angiosperm lineages.

Plant Cell 16 : 2772-2784 [PubMed]


Ober, D. (2003)

Chemical ecology of alkaloids exemplified with the pyrrolizidines.

Recent Adv. Phytochem. (J. T. Romeo et al., eds., Pergamon, Amsterdam) 37, : 203-230 [Request Reprint]


Ober, D., Harms, R., Witte, L., Hartmann, T. (2003)

Molecular evolution by change of function: Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein.

J. Biol. Chem. 278 : 12805-12812 [PubMed]


Ober, D., Gibas, L., Witte, L., Hartmann, T. (2003)

Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase.

Phytochemistry 62 : 339-344 [PubMed]


Hartmann,T., Ober,D. (2003)

Der pflanzliche Sekundärstoffwechsel: Biologische Notwendigkeit und pharmazeutischer Nutzen.

Carolo-Wilhelmina: Forschungsmagazin der Technischen Universität Braunschweig 38 : 26-32 [pdf ]


Moll, S. ,Anke, S., Kahmann, U., Hansch, R., Hartmann, T., Ober, D. (2002)

Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase.

Plant Physiology 130 : 47-57 [PubMed]


Naumann, C., Hartmann, T., Ober, D. (2002)

Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae.

Proc. Natl. Acad. Sci. U. S. A. 99 : 6085-90 [PubMed]


Ober, D. (2001)

Warum gibt es Gift- und Arzneipflanzen? Die Evolution des pflanzlichen Sekundärstoffwechsels am Beispiel der Pyrrolizidin-Alkaloide.

Deutsche Apotheker Zeitung 141 : 2127-2131


Ober, D., Hartmann, T. (2000)

Phylogenetic origin of a secondary pathway: The case of pyrrolizidine alkaloids.

Plant Mol. Biol. 44 : 445-450 [PubMed]


Ober, D., Harms, R., Hartmann, T. (2000)

Cloning and expression of homospermidine synthase from Senecio vulgaris: A revision.

Phytochemistry 55 : 305-309 [PubMed]


Hartmann, T., Ober, D. (2000)

Biosynthesis and metabolism of pyrrolizidine alkaloids in plants and specialized insect herbivores.

Top. Curr. Chem. 209 : 207-244


Ober, D., Hartmann, T. (1999)

Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase.

Proc. Natl. Acad. Sci. U. S. A. 96 : 14777-14782 [PubMed]


Ober, D., Hartmann, T. (1999)

Deoxyhypusine synthase from tobacco: cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity.

J. Biol. Chem. 274 : 32040-32047 [PubMed]


Tholl, D., Ober, D., Martin, W., Kellermann, J., Hartmann, T. (1996)

Purification, molecular cloning and expression in Escherichia coli of homospermidine synthase from Rhodopseudomonas viridis.

Eur. J. Biochem. 240 : 373-379 [PubMed]


Ober, D.,Tholl, D.,Martin, W.,Hartmann, T. (1996)

Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli.

J. Gen. Appl. Microbiol. 42 : 411-419


Böttcher, F., Ober, D., Hartmann, T. (1994)

Biosynthesis of pyrrolizidine alkaloids: Putrescine and spermidine are essentail substrates of enzymatic homospermidine formation.

Can. J. Chem. 72 : 80-85

 
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