Kiel University at the Hannover Messe 2018

CHANNELMAT: Microchannels for controlling cellular mechanotransduction

HEALTH SOLUTIONS
lecture: 27.4.2018, Hannover Messe, Hall 2, CAU booth C07
time: 2:00 pm
language: English
with day exhibit


Cellular mechanotransduction is the process of transferring mechanical signals into cellular reactions. It has great impact on cellular activity by modifying their proliferation, migration, differentiation and cell adhesion. These cellular properties are also influenced by the 3D architecture of their extracellular environment. We present a highly attractive 3D interconnected micro-channeled soft biomaterial to mimic architecture and mechanical properties of the natural cellular environment and thus to control cellular mechanotransduction pathways. The fabrication process is based on hydrolyzing micrometered-sized ZnO tetrapods within a hydrogel, leading to hollow interconnected channels inside the hydrogel. The material possesses unique features such as a high micropore fraction >75 vol% as well as adoptable mechanical properties of the hydrogel. Hence, by providing large cell-material contact area and controllable mechanical properties, an excellent control on cells can be achieved.

Speaker Prof. Christine Selhuber-Unkel

Kaiserstraße 2, R. A-104
Phone: +49 431 880-6198
Telefax: +49 431 880-6290
cse@tf.uni-kiel.de

  • Since 2011 Professor (W2) for Biocompatible Nanomaterials, University of Kiel
  • 2010-2011 Assistant Professor (W1) for Biocompatible Nanomaterials, University of Kiel
  • and Emmy Noether Group Leader
  • 2009-2010 Postdoc, Zoological Institute, University of Kiel (Prof. Leippe)
  • 2007-2009 Postdoc, Niels Bohr Institute, University of Copenhagen, Denmark
  • (Prof.Oddershede)
  • 2007-2008 Adjunktpædagogikum, i.e. Danish Higher Education Teaching Training
  • 2007 Postdoc, University of Heidelberg & MPI for Metals Research (Prof. J. Spatz)
  • 2003-2006 Dr. rer. nat. in Physics, Department Biophysical Chemistry, University of
  • Heidelberg, Prof. J. Spatz, „summa cum laude“
  • 2002-2003 Master degree studies and Master thesis in Physics, Uppsala University, Sweden
  • 2001-2002 Research assistant, German Cancer Research Center (DKFZ), Heidelberg
  • 2000-2002 Master studies in Physics, University of Heidelberg

 

AWARDS

  • 2014 Feodor -Lynen-fellowship for experienced scientists of the Alexander-von-
  • Humboldt-Foundation for a research stay at Cornell University
  • 2013 ERC Starting Grant
  • 2008 Otto-Hahn-Medal of the Max-Planck-Society
  • 2007 Dieter-Rampacher-Prize of the Max-Planck-Society
  • 2006 Wilma-Moser-Prize from the University of Heidelberg
  • 2001-2003 Scholarship from the German National Academic Foundation (Studienstiftung)
  • 2000-2003 Scholarship from the Bavarian Education Program for Excellent Students

 

FIELDS OF INTEREST

  • Nano-and microstructured biomaterials, adaptive cell-inspired materials, biophysics of cells (mechanotransduction, cell adhesion, intracellular dynamics)