Genetic architecture of natural variation in pathogen avoidance

Parasite-mediated selection is well known to be a driving force in the evolution of animal behavior, especially those behaviours that reduce contact with parasites (i.e., avoidance behaviours). As a consequence of the selective pressure, hosts often show substantial intra-specific variation in these defensive behaviours. In turn, the study of the genetic basis of such natural variation should enable us to identify potential targets of parasite-mediated selection and yield insight into the underlying genetic architecture (e.g. genetic interactions, which contribute to specific behaviours). During this project, we focus on an analysis of quantitative trait loci (QTL) using recombinant inbred lines (RILs) and near isogenic lines (NILs) derived from a cross of two genetically as well as phenotypically distinct natural isolates. More details on this project will appear on this page in the future.

Involved people: Rania Nakad, Timm Mohr, Katja Dierking, Hinrich Schulenburg

Co-supervisor: Jan Kammenga, Basten Snoek (both Wageningen, NL)

Funding: German Science Foundation (Deutsche Forschungsgemeinschaft, DFG; project SCHU 1415/6-1)