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Univ. Prof. Dr. Stefan Rose-John

Stefan Rose-John
Stefan Rose-John
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Molecular Biology of Cytokines

Publications

 
Original Publications
Reviews
 

Selected Original Publications

309
Soluble interleukin-6 receptor in patients with JAK2V617F somatic mutation and myeloproliferative neoplasm.
Garbers C, Rose-John S.
EClinicalMedicine. 2020 May 3;22:100340
 
308
Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells.
Lokau J, Kleinegger F, Garbers Y, Waetzig GH, Grötzinger J, Rose-John S, Haybaeck J, Garbers C.
PLoS One. 2020 May 4;15(5):e0232612
 
307
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner.
Willis EF, MacDonald KPA, Nguyen QH, Garrido AL, Gillespie ER, Harley SBR, Bartlett PF, Schroder WA, Yates AG, Anthony DC, Rose-John S, Ruitenberg MJ, Vukovic J.
Cell. 2020 Mar 5;180(5):833-846
 
306
Interleukin-6 plays a critical role in aldosterone-induced macrophage recruitment and infiltration in the myocardium.
Liao CW, Chou CH, Wu XM, Chen ZW, Chen YH, Chang YY, Wu VC, Rose-John S, Hung CS, Lin YH; TAIPAI Study Group.
Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165627
 
305
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C.
Cell Mol Life Sci. 2020 Jan;77(2):331-350
 
304
IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling.
Wilkinson AN, Chang K, Kuns RD, Henden AS, Minnie SA, Ensbey KS, Clouston AD, Zhang P, Koyama M, Hidalgo J, Rose-John S, Varelias A, Vuckovic S, Gartlan KH, Hill GR.
Blood. 2019 Dec 5;134(23):2092-2106
 
303
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C.
Gut. 2019 Nov 4. pii: gutjnl-2019-319200. doi: 10.1136/gutjnl-2019-319200. [Epub ahead of print]
 
302
IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.
Escrig A, Canal C, Sanchis P, Fernández-Gayol O, Montilla A, Comes G, Molinero A, Giralt M, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J.
Brain Behav Immun. 2019 Nov;82:145-159
 
301
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C.
FASEB J. 2019 Nov;33(11):11925-11940
 
300
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, Yang C, Kowalski GM, O'Reilly L, Egan C, Sun E, Thai LM, Krippner G, Adams TE, Lee RS, Grötzinger J, Garbers C, Risis S, Kraakman MJ, Mellet NA, Sligar J, Kimber ET, Young RL, Cowley MA, Bruce CR, Meikle PJ, Baldock PA, Gregorevic P, Biden TJ, Cooney GJ, Keating DJ, Drucker DJ, Rose-John S, Febbraio MA.
Nature. 2019 Oct;574(7776):63-68
 
299
Interleukin 6 Dependent Synaptic Plasticity in a Social Defeat-Susceptible Prefrontal Cortex Circuit.
Esquivel-Rendón E, Vargas-Mireles J, Cuevas-Olguín R, Miranda-Morales M, Acosta-Mares P, García-Oscos F, Pineda JC, Salgado H, Rose-John S, Atzori M.
Neuroscience 2019 Aug 21;414:280-296
 
298
Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.
Scherger AK, Al-Maarri M, Maurer HC, Schick M, Maurer S, Öllinger R, Gonzalez-Menendez I, Martella M, Thaler M, Pechloff K, Steiger K, Sander S, Ruland J, Rad R, Quintanilla-Martinez L, Wunderlich FT, Rose-John S, Keller U.
JCI Insight 2019 Aug 8;4(15)
 
297
The IL-6-neutralizing sIL-6R/sgp130 buffer system is disturbed in patients with type 2 diabetes.
Aparicio-Siegmund S, Garbers Y, Flynn CM, Waetzig GH, Gouni-Berthold I, Krone W, Berthold HK, Laudes M, Rose-John S, Garbers C.
Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E411-E420
 
296
The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients.
Dos Santos Guilherme M, Stoye NM, Rose-John S, Garbers C, Fellgiebel A, Endres K.
Front Aging Neurosci. 2019 Jul 23;11:182
 
295
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.
Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.
Int J Mol Sci. 2019 Jul 26;20(15)
 
294
The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis.
Saad MI, McLeod L, Yu L, Ebi H, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
Carcinogenesis 2019 Jun 27. pii: bgz123. doi: 10.1093/carcin/bgz123. [Epub ahead of print]
 
293
Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3.
Servais FA, Kirchmeyer M, Hamdorf M, Minoungou NWE, Rose-John S, Kreis S, Haan C, Behrmann I.
Mol Ther Nucleic Acids. 2019 Jun 7;16:419-433
 
292
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation.
Pavlenko E, Cabron AS, Arnold P, Dobert JP, Rose-John S, Zunke F.
Int J Mol Sci. 2019 May 4;20(9)
 
291
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
EMBO Mol Med. 2019 Apr;11(4)
 
290
ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury.
Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, Bogie J, Vanmierlo T, Vidal PM, Rose-John S, Gou-Fabregas M, Hendrix S.
Brain Behav Immun. 2019 Mar 6
 
289
Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown.
Quarta S, Mitrić M, Kalpachidou T, Mair N, Schiefermeier-Mach N, Andratsch M, Qi Y, Langeslag M, Malsch P, Rose-John S, Kress M.
FASEB J. 2019 Mar;33(3):4418-4431
 
288
Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.
Kleinegger F, Hofer E, Wodlej C, Golob-Schwarzl N, Birkl-Toeglhofer AM, Stallinger A, Petzold J,Orlova A, Krassnig S, Reihs R, Niedrist T, Mangge H, Park YN, Thalhammer M, Aigelsreiter A, Lax S, Garbers C, Fickert P, Rose-John S, Moriggl R, Rinner B, Haybaeck J.
Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):308-321
 
287
Correction to: A new multiple trauma model of the mouse.
Fitschen-Oestern S, Lippross S, Klueter T, Weuster M, Varoga D, Tohidnezhad M, Pufe T, Rose-John S, Andruszkow H, Hildebrand F, Steubesand N, Seekamp A, Neunaber C.
BMC Musculoskelet Disord. 2019 Feb 11;20(1):72
 
286
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Paige E, Clément M, Lareyre F, Sweeting M, Raffort J, Grenier C, Finigan A, Harrison J, Peters JE, Sun BB, Butterworth AS, Harrison SC, Bown MJ, Lindholt JS, Badger SA, Kullo IJ, Powell J, Norman PE, Scott DJA, Bailey MA, Rose-John S, Danesh J, Freitag DF, Paul DS, Mallat Z.
Circ Genom Precis Med. 2019 Feb;12(2):e002413
 
285
Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation byproteolytic cleavage.
Prenissl N, Lokau J, Rose-John S, Haybaeck J, Garbers C.
Cytokine. 2019 Feb;114:1-5
 
284
Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.
Agthe M, Brügge J, Garbers Y, Wandel M, Kespohl B, Arnold P, Flynn CM, Lokau J, Aparicio-Siegmund S, Bretscher C, Rose-John S, Waetzig GH, Putoczki T, Grötzinger J, Garbers C.
Cell rep. 2019 Jan;156(1):145-159.e19
 
283
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice.
Aden K, Bartsch K, Dahl J, Reijns MAM, Esser D, Sheibani-Tezerji R, Sinha A, Wottawa F, Ito G, Mishra N, Knittler K, Burkholder A, Welz L, van Es J, Tran F, Lipinski S, Kakavand N, Boeger C, Lucius R, von Schoenfels W, Schafmayer C, Lenk L, Chalaris A, Clevers H, Röcken C, Kaleta C, Rose-John S, Schreiber S, Kunkel T, Rabe B, Rosenstiel P.
Gastroenterology. 2019 Jan;156(1):145-159.e19
 
282
Interleukin 6 Trans-Signalling and Risk of Future Cardiovascular Events.
Ziegler L, Gajulapuri A, Frumento P, Bonomi A, Wallén H, de Faire U, Rose-John S, Gigante B.
Cardiovasc Res 2019 Jan 1;115(1):213-221
 
281
Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T.
J Clin Invest 2018 Nov 1;128(11):5056-5072
 
280
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
Cabron AS, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert JP, Pavlenko E, Schumacher N,Renné T, Taylor PR, Linder S, Rose-John S, Zunke F.
J Immunol 2018 Nov 15;201(10):3106-3118
 
279
Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis.
Stahl FR, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck PC, Brune W, Renné T.
Sci Rep 2018 Oct 4;8(1):14823
 
278
Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Nivarthi H, Gordziel C,Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S,Friedrich K, Moriggl R.
Oncotarget 2018 Sep 18;9(73):33865
 
277
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells.
Lücke K, Yan I, Krohn S, Volmari A, Klinge S, Schmid J, Schumacher V, Steinmetz OM, Rose-John S, Mittrücker HW.
PLoS One 2018 Aug 31;13(8):e0203395
 
276
Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice.
Holz K, Prinz M, Brendecke SM, Hölscher A, Deng F, Mitrücker HW, Rose-John S, Hölscher C.
Front Immunol 2018 May 2;9:836
 
275
Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.
Kaiser K, Prystaz K, Vikman A, Haffner-Luntzer M, Bergdolt S, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Naunyn Schmiedebergs Arch Pharmacol 2018 May;391(5):523-536
 
274
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.
J Exp Med 2018 Apr 2;215(4):1205-1225
 
273
BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.
Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K.
J Clin Invest 2018 Mar 1;128(3):916-930
 
272
Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer.
Garbers C, Rose-John S.
Methods Mol Biol. 2018;1725:127-140
 
271
The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpectedfunction of ADAM-17 in necroptosis.
Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D.
Oncotarget 2018 Feb 5;9(16):12941-12958
 
270
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.
Prystaz K, Kaiser K, Kovtun A, Haffner-Luntzer M, Fischer V, Rapp AE, Liedert A, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Am J Pathol. 2018 Feb;188(2):474-490
 
269
The ADAM17 Metalloproteinase Maintains Arterial Elasticity.
Nicolaou A, Northoff BH, Zhao Z, Kohlmaier A, Sass K, Rose-John S, Steffens S, Weber C, Teupser D, Holdt LM.
Thromb Haemost 2018 Jan;118(1):210-213
 
268
Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.
Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker HW, Squire A, Engel DR.
J Leukoc Biol. 2018 Jan;103(1):13-22
 
267
Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C.
Front Immunol. 2017 Nov 10;8:1537
 
266
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.
Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.
Oncoimmunology 2017 Oct 26;7(1):e1368603
 
265
Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.
Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.
Front Physiol. 2017 Oct 9;8:775
 
264
The role of ADAM17 in the T-cell response against bacterial pathogens.
Link MA, Lücke K, Schmid J, Schumacher V, Eden T, Rose-John S, Mittrücker HW.
PLoS One. 2017 Sep 6;12(9):e0184320
 
263
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice.
Tode J, Richert E, Koinzer S, Klettner A, Pickhinke U, Garbers C, Rose-John S, Nölle B, Roider J.
Cytokine. 2017 Aug;96:8-15
 
262
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C.
Oncotarget 2017 Jul 4;8(33):54873-54888
 
261
EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.
Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.
Gastroenterology 2017 Jul;153(1):178-190.e10
 
2260
Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.
Kammoun HL, Allen TL, Henstridge DC, Kraakman MJ, Peijs L, Rose-John S, Febbraio MA.
PLoS One. 2017 Jun 20;12(6):e0179099
 
259
IL6-Dependent Genomic Instability Heralds Accelerated Carcinogenesis Following Liver Regeneration on a Background of Chronic Hepatitis.
Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, Rosenberg N, Paldor M, Goldenberg D, Sonnenblick A, Peled A, Rose-John S, Galun E, Axelrod JH.
Hepatology. 2017 May;65(5):1600-1611
 
258
Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.
Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose-John S, Knolle PA, Wohlleber D.
J Hepatol. 2017 May;66(5):978-986
 
257
IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.
Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC.
Cell Rep. 2017 Apr 11;19(2):267-280
 
256
The balance between Treg and TH17 cells: CD11b and interleukin-6.
Garbers C, Rose-John S.
Eur J Immunol. 2017 Apr;47(4):629-632
 
255
Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Balic JJ, Garbers C, Rose-John S, Yu L, Jenkins BJ.
Cytokine. 2017 Apr;92:118-123
 
254
Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.
Sontag S, Förster M, Qin J, Wanek P, Mitzka S, Schüler HM, Koschmieder S, Rose-John S, Seré K, Zenke M.
Stem Cells. 2017 Apr;35(4):898-908
 
253
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.
Sci Rep. 2017 Mar 9;7:44053
 
252
Instructive Role of the Microenvironment in Preventing Renal Fibrosis.
Matsumoto K, Xavier S, Chen J, Kida Y, Lipphardt M, Ikeda R, Gevertz A, Caviris M, Hatzopoulos AK, Kalajzic I, Dutton J, Ratliff BB, Zhao H, Darzynkiewicz Z, Rose-John S, Goligorsky MS.
Stem Cells Transl Med. 2017 Mar;6(3):992-1005
 
251
Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth.
Burger R, Günther A, Klausz K, Staudinger M, Peipp M, Penas EM, Rose-John S, Wijdenes J, Gramatzki M.
Haematologica. 2017 Feb;102(2):381-390
 
250
Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM.
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):247-257
 
249
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.
PLoS Biol. 2017 Jan 6;15(1):e2000080
 
248
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.
Nat Immunol. 2017 Jan;18(1):74-85
 
247
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D.
Hepatology. 2017 Jan;65(1):89-103
 
246
Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.
Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505
 
245
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.
Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P.
Oncogenesis. 2016 Nov 21;5(11):e270
 
244
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.
Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.
J Immunol. 2016 Nov 1;197(9):3705-3715
 
243
Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts.
Heckt T, Keller J, Peters S, Streichert T, Chalaris A, Rose-John S, Mell B, Joe B, Amling M, Schinke T.
Bone. 2016 Nov;92:85-93
 
242
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schäfers M, Holl R.
J Med Chem. 2016 Oct 27;59(20):9541-9559
 
241
ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A.
JCI Insight. 2016 Aug 18;1(13)
 
240
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response.
Heim D, Gil-Ibanez I, Herden J, Parplys AC, Borgmann K, Schmidt-Arras D, Lohse AW, Rose-John S, Wege H.
Oncotarget. 2016 Aug 23;7(34):55639-55648
 
239
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A.
Elife. 2016 Aug 1;5
 
238
Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.
Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C.
J Biol Chem. 2016 Jul 29;291(31):16186-96
 
237
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
Wörmann SM, Song L, Ai J, Diakopoulos KN, Kurkowski MU, Görgülü K, Ruess D, Campbell A, Doglioni C, Jodrell D, Neesse A, Demir IE, Karpathaki AP, Barenboim M, Hagemann T, Rose-John S, Sansom O, Schmid RM, Protti MP, Lesina M, Algül H.
Gastroenterology. 2016 Jul;151(1):180-193.e12
 
236
Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer.
Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K
Gut. 2016 Jul;65(7):1139-50
 
235
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, White JC, Nazimuddin F, Wertheim G, Levine BL, June CH, Porter DL, Grupp SA.
Cancer Discov. 2016 Jun;6(6):664-79
 
234
Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.
Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.
Sci Rep. 2016 May 6;6:25550
 
233
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.
J Leukoc Biol. 2016 May;99(5):749-60
 
232
Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts.
Malysheva K, de Rooij K, Lowik CW, Baeten DL, Rose-John S, Stoika R, Korchynskyi O.
Croat Med J. 2016 Apr 23;57(2):89-98
 
231
Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.
Birner P, Heider S, Petzelbauer P, Wolf P, Kornauth C, Kuroll M, Merkel O, Steiner G, Kishimoto T, Rose-John S, Soleiman A, Moriggl R, Kenner L.
Exp Dermatol. 2016 Apr;25(4):305-10
 
230
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D.
Oncotarget. 2016 Apr 5;7(14):17431-41.
 
229
Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation.
Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, Eliashar R, Mizrachi L, Orfaig-Geva C, Baum BJ, Rose-John S, Galun E, Axelrod JH.
Cancer Res. 2016 Mar 1;76(5):1170-80
 
228
Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA.
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3006-11
 
227
KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.
Rosean TR, Holman CJ, Tompkins VS, Jing X, Krasowski MD, Rose-John S, Janz S.
Blood Cancer J. 2016 Feb 26;6:e398
 
226
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.
Cell Rep. 2016 Feb 23;14(7):1761-1773
 
225
A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.
Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C.
Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6
 
224
IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.
Brooks GD, McLeod L, Alhayyani S, Miller A, Russell PA, Ferlin W, Rose-John S, Ruwanpura S, Jenkins BJ.
Cancer Res. 2016 Feb 15;76(4):866-76
 
223
IL-6 Trans-Signaling Drives Murine Crescentic GN.
Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J
J Am Soc Nephrol. 2016 Jan;27(1):132-42
 
222
Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.
Holmer R, Wätzig GH, Tiwari S, Rose-John S, Kalthoff H.
BMC Cancer. 2015 Dec 16;15:975.
 
221
RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.
Mittelberger F, Meyer C, Waetzig GH, Zacharias M, Valentini E, Svergun DI, Berg K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U.
RNA Biol. 2015;12(9):1043-53
 
220
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.
Schumacher N, Meyer D, Mauermann A, von der Heyde J, Wolf J, Schwarz J, Knittler K, Murphy G, Michalek M, Garbers C, Bartsch JW, Guo S, Schacher B, Eickholz P, Chalaris A, Rose-John S, Rabe B.
J Biol Chem. 2015 Oct 23;290(43):26059-71
 
219
Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
Grill M, Syme TE, Noçon AL, Lu AZ, Hancock D, Rose-John S, Campbell IL
Glia. 2015 Oct;63(10):1738-52
 
218
Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.
Ullah MA, Revez JA, Loh Z, Simpson J, Zhang V, Bain L, Varelias A, Rose-John S, Blumenthal A, Smyth MJ, Hill GR, Sukkar MB, Ferreira MA, Phipps S
J Allergy Clin Immunol. 2015 Oct;136(4):1065-73
 
217
Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer.
Goumas FA, Holmer R, Egberts JH, Gontarewicz A, Heneweer C, Geisen U, Hauser C, Mende MM, Legler K, Röcken C, Becker T, Waetzig GH, Rose-John S, Kalthoff H
Int J Cancer. 2015 Sep 1;137(5):1035-46
 
216
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
Kreins AY, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT, Halwani R, Grant AV, Boisson B, Bogunovic D, Itan Y, Moncada-Velez M, Martinez-Barricarte R, Migaud M, Deswarte C, Alsina L, Kotlarz D, Klein C, Muller-Fleckenstein I, Fleckenstein B, Cormier-Daire V, Rose-John S, Picard C, Hammarstrom L, Puel A, Al-Muhsen S, Abel L, Chaussabel D, Rosenzweig SD, Minegishi Y, Tangye SG, Bustamante J, Casanova JL, Boisson-Dupuis S.
J Exp Med. 2015 Sep 21;212(10):1641-62
 
215
STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.
Nat Commun. 2015 Jul 22;6:7736
 
214
A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.
Hong SS, Choi JH, Lee SY, Park YH, Park KY, Lee JY, Kim J, Gajulapati V, Goo JI, Singh S, Lee K, Kim YK, Im SH, Ahn SH, Rose-John S, Heo TH, Choi Y.
J Immunol. 2015 Jul 1;195(1):237-45
 
213
Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM.
J Am Soc Nephrol. 2015 Jul;26(7):1597-607
 
212
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.
Beyer C, Huang J, Beer J, Zhang Y, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Maier C, Munoz L, Krönke G, Uderhardt S, Distler O, Jones S, Rose-John S, Oravecz T, Schett G, Distler JH
Ann Rheum Dis. 2015 Jun;74(6):1317-24
 
211
Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat.
Garcia-Oscos F, Peña D, Housini M, Cheng D, Lopez D, Cuevas-Olguin R, Saderi N, Salgado Delgado R, Galindo Charles L, Salgado Burgos H, Rose-John S, Flores G, Kilgard MP, Atzori M
J Neurosci Res. 2015 Jun;93(6):859-65
 
210
Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma.
Mackiewicz J, Karczewska-Dzionk A, Laciak M, Kapcinska M, Wiznerowicz M, Burzykowski T, Zakowska M, Rose-John S, Mackiewicz A.
Medicine (Baltimore). 2015 May;94(21):e853
 
209
IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans.
Müller N, Schulte DM, Türk K, Freitag-Wolf S, Hampe J, Zeuner R, Schröder JO, Gouni-Berthold I, Berthold HK, Krone W, Rose-John S, Schreiber S, Laudes M
J Lipid Res. 2015 May;56(5):1034-42
 
208
Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.
van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM
Am J Pathol. 2015 Apr;185(4):1145-55
 
207
Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.
Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, EstevezE, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S,Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A,Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA
Cell Metab. 2015 Mar 3;21(3):403-16
 
206
Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome.
Garbers C, Rose-John S
J Proteome Res. 2015 Feb 6;14(2):1330-2
 
205
ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis.
Caolo V, Swennen G, Chalaris A, Wagenaar A, Verbruggen S, Rose-John S, Molin DG, Vooijs M, Post MJ
Angiogenesis. 2015 Jan;18(1):13-22
 
 
203
Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex.
Garcia-Oscos F, Peña D, Housini M, Cheng D, Lopez D, Borland MS, Salgado-Delgado R, Salgado H, D'Mello S, Kilgard MP, Rose-John S, Atzori M
Brain Behav Immun. 2015 Jan;43:149-58
 
202
Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease.
Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reißig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T
Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2658-68
 
201
GP130 activation induces myeloma and collaborates with MYC.
Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U
J Clin Invest. 2014 Dec;124(12):5263-74
 
200
Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6.
Reif A, Siebenhaar S, Tröster A, Schmälzlein M, Lechner C, Velisetty P, Gottwald K, Pöhner C, Boos I, Schubert V, Rose-John S, Unverzagt C
Angew Chem Int Ed Engl. 2014 Nov 3;53(45):12125-31
 
199
Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency.
Martínez-Barricarte R, Megged O, Stepensky P, Casimir P, Moncada-Velez M, Averbuch D, Assous MV, Abuzaitoun O, Kong XF, Pedergnana V, Deswarte C, Migaud M, Rose-John S, Itan Y, Boisson B, Belkadi A, Conti F, Abel L, Vogt G, Boisson-Dupuis S, Casanova JL, Bustamante J
J Clin Immunol. 2014 Nov;34(8):904-9
 
198
Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.
Effenberger T, von der Heyde J, Bartsch K, Garbers C, Schulze-Osthoff K, Chalaris A, Murphy G, Rose-John S, Rabe B
FASEB J. 2014 Nov;28(11):4847-56
 
197
Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.
Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C
PLoS One. 2014 Sep 26;9(9):e107990
 
196
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.
Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF
Cell Metab. 2014 Sep 2;20(3):433-47
 
195
Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.
Quarta S, Baeumer BE, Scherbakov N, Andratsch M, Rose-John S, Dechant G, Bandtlow CE, Kress M
J Neurosci. 2014 Sep 24;34(39):13222-33
 
194
The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.
Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J
J Immunol. 2014 Sep 15;193(6):2753-63
 
193
IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.
Böttcher JP, Schanz O, Garbers C, Zaremba A, Hegenbarth S, Kurts C, Beyer M, Schultze JL, Kastenmüller W, Rose-John S, Knolle PA
Cell Rep. 2014 Sep 11;8(5):1318-27
 
192
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J
Biochim Biophys Acta. 2014 Sep;1842(9):1485-94
 
191
Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.
Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA
Diabetes. 2014 Sep;63(9):2984-95
 
190
Dendritic cell development requires histone deacetylase activity.
Chauvistré H, Küstermann C, Rehage N, Klisch T, Mitzka S, Felker P, Rose-John S, Zenke M, Seré KM
Eur J Immunol. 2014 Aug;44(8):2478-88
 
189
RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.
Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N
Cardiovasc Res. 2014 Jul 15;103(2):206-16
 
188
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.
Schlecker E, Fiegler N, Arnold A, Altevogt P, Rose-John S, Moldenhauer G, Sucker A, Paschen A, von Strandmann EP, Textor S, Cerwenka A
Cancer Res. 2014 Jul 1;74(13):3429-40
 
187
The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).
Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J
J Biol Chem. 2014 Jun 27;289(26):18442-50
 
186
A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.
Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J
J Biol Chem. 2014 Jun 6;289(23):16336-48
 
185
Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.
Aparicio-Siegmund S, Sommer J, Monhasery N, Schwanbeck R, Keil E, Finkenstädt D, Pfeffer K, Rose-John S, Scheller J, Garbers C
Oncotarget. 2014 Apr 30;5(8):2131-48
 
184
IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions.
Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A
J Invest Dermatol. 2014 Mar;134(3):728-735
 
183
Stabilized Interleukin-6 receptor binding RNA aptamers.
Meyer C, Berg K, Eydeler-Haeder K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U
RNA Biol. 2014;11(1):57-65
 
182
Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.
Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J
Biochim Biophys Acta. 2014 Feb;1843(2):275-87
 
181
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J
J Neurosci. 2014 Feb 12;34(7):2503-13
 
180
Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.
Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A
J Biol Chem. 2014 Jan 31;289(5):3080-93
 
179
Oncogenic deletion mutants of gp130 signal from intracellular compartments.
Schmidt-Arras D, Müller M, Stevanovic M, Horn S, Schütt A, Bergmann J, Wilkens R, Lickert A, Rose-John S
J Cell Sci. 2014 Jan 15;127(Pt 2):341-53
 
178
"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells.
Trilling M, Le VT, Rashidi-Alavijeh J, Katschinski B, Scheller J, Rose-John S, Androsiac GE, Jonjic S, Poli V, Pfeffer K, Hengel H
J Immunol. 2014 Jan 1;192(1):447-58
 
177
T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
Dewitz C, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S
FEBS J. 2014 Jan;281(1):157-74
 
176
ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.
Vidal PM, Lemmens E, Avila A, Vangansewinkel T, Chalaris A, Rose-John S, Hendrix S
Cell Death Dis. 2013 Dec 12;4:e954
 
175
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A
Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367
 
174
Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
J Immunol. 2013 Dec 1;191(11):5574-82
 
173
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3).
Möller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J
J Biol Chem. 2013 Nov 29;288(48):34529-44
 
172
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).
Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J
Cell Cycle. 2013 Nov 1;12(21):3421-32
 
171
Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions.
Martin P, Palmer G, Vigne S, Lamacchia C, Rodriguez E, Talabot-Ayer D, Rose-John S, Chalaris A, Gabay C
J Leukoc Biol. 2013 Oct;94(4):791-802
 
170
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice.
Tsantikos E, Maxwell MJ, Putoczki T, Ernst M, Rose-John S, Tarlinton DM, Hibbs ML.
Arthritis Rheum. 2013 Oct;65(10):2691-702
 
169
Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets.
Marino M, Scuderi F, Ponte E, Maiuri MT, De Cristofaro R, Provenzano C, Rose-John S, Cittadini A, Bartoccioni E
J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):841-52
 
168
Trp53 deficiency protects against acute intestinal inflammation.
Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.
J Immunol. 2013 Jul 15;191(2):837-47
 
167
An analysis of the function and expression of D6 on lymphatic endothelial cells.
McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ
Blood. 2013 May 2;121(18):3768-77
 
166
In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, Shriki A, Klaus S, Rosen S, Rose-John S, Galun E, Axelrod JH, Heyman SN
Clin Exp Pharmacol Physiol. 2013 Apr;40(4):262-72
 
165
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H
J Clin Invest. 2013 Mar;123(3):1019-31
 
164
The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model.
Wei LH, Chou CH, Chen MW, Rose-John S, Kuo ML, Chen SU, Yang YS
J Clin Endocrinol Metab. 2013 Mar;98(3):E472-84
 
163
gp130 activation is regulated by D2-D3 interdomain connectivity.
Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D
Biochem J. 2013 Mar 15;450(3):487-96
 
162
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.
Braun O, Dewitz C, Möller-Hackbarth K, Scheller J, Schiffelholz T, Baier PC, Rose-John S (2013)
J Interferon Cytokine Res. 2013 May;33(5):254-60
 
161
ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.
Trad A, Hansen HP, Shomali M, Peipp M, Klausz K, Hedemann N, Yamamoto K, Mauermann A, Desel C, Lorenzen I, Lemke H, Rose-John S, Grötzinger J
Cancer Immunol Immunother. 2013 Mar;62(3):411-21
 
160
mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.
Derer S, Till A, Haesler R, Sina C, Grabe N, Jung S, Nikolaus S, Kuehbacher T, Groetzinger J, Rose-John S, Rosenstiel PC, Schreiber S
Gut. 2013 Mar;62(3):376-86
 
159
d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers.
Magbanua E, Zivkovic T, Hansen B, Beschorner N, Meyer C, Lorenzen I, Grötzinger J, Hauber J, Torda AE, Mayer G, Rose-John S, Hahn U
RNA Biol. 2013 Feb;10(2):216-27
 
158
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, Rose-John S, Grötzinger J, Lorenzen I, Scheller J
J Biol Chem. 2013 Feb 8;288(6):4346-54
 
157
Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction.
Samavedam UK, Kalies K, Scheller J, Sadeghi H, Gupta Y, Jonkman MF, Schmidt E, Westermann J, Zillikens D, Rose-John S, Ludwig RJ
J Autoimmun. 2013 Feb;40:74-85
 
156
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, Engel DR, Scheller J, Rose-John S, Mittrücker HW
J Immunol. 2013 Jan 15;190(2):703-11
 
155
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C
Cell Mol Life Sci. 2013 Jan;70(2):309-33
 
154
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B
J Thromb Haemost. 2012 Dec;10(12):2581-92
 
153
Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.
Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, Rose-John S, Scheller J, Thiery J, Kratzsch J.
PLoS One. 2012;7(4):e34787
 
152
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis.
Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John S, Ehlers S, Hölscher C
Immunobiology. 2012 Oct;217(10):996-1004
 
151
Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.
ElSharawy A, Warner J, Olson J, Forster M, Schilhabel MB, Link DR, Rose-John S, Schreiber S, Rosenstiel P, Brayer J, Franke A
BMC Genomics. 2012 Sep 20;13:500
 
150
Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis.
Gerlach K, Daniel C, Lehr HA, Nikolaev A, Gerlach T, Atreya R, Rose-John S, Neurath MF, Weigmann B
Cancer Res. 2012 Sep 1;72(17):4340-50
 
149
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.
O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE
EMBO Mol Med. 2012 Sep;4(9):939-51
 
148
A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.
Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S
Biochem J. 2012 Jul 1;445(1):135-44
 
147
Dendritic cell lineage commitment is instructed by distinct cytokine signals.
Seré KM, Lin Q, Felker P, Rehage N, Klisch T, Ortseifer I, Hieronymus T, Rose-John S, Zenke M
Eur J Cell Biol. 2012 Jun-Jul;91(6-7):515-23
 
146
Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection.
Mackiewicz A, Mackiewicz J, Wysocki PJ, Wiznerowicz M, Kapcinska M, Laciak M, Rose-John S, Izycki D, Burzykowski T, Karczewska-Dzionk A
Expert Opin Investig Drugs. 2012 Jun;21(6):773-83. Erratum in: Expert Opin Investig Drugs. 2012 Jul;21(7):1065.
 
145
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, Janz S, Scheller J, Rose-John S
Blood. 2012 May 31;119(22):5173-81
 
144
The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.
Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J
FEBS Lett. 2012 Apr 24;586(8):1093-100
 
143
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J
J Biol Chem. 2012 Apr 20;287(17):13743-51
 
142
The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling.
Garcia-Oscos F, Salgado H, Hall S, Thomas F, Farmer GE, Bermeo J, Galindo LC, Ramirez RD, D'Mello S, Rose-John S, Atzori M
Biol Psychiatry. 2012 Apr 1;71(7):574-82
 
141
A designer hyper interleukin 11 (H11) is a biologically active cytokine.
Dams-Kozlowska H, Gryska K, Kwiatkowska-Borowczyk E, Izycki D, Rose-John S, Mackiewicz A
BMC Biotechnol. 2012 Mar 21;12:8
 
140
IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.
Traum D, Timothee P, Silver J, Rose-John S, Ernst M, LaRosa DF
J Leukoc Biol. 2012 Mar;91(3):427-35
 
139
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K
Arterioscler Thromb Vasc Biol 2012 Feb;32(2):281-90
 
138
Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells.
Meyer C, Eydeler K, Magbanua E, Zivkovic T, Piganeau N, Lorenzen I, Grötzinger J, Mayer G, Rose-John S, Hahn U
RNA Biol. 2012 Jan;9(1):67-80
 
137
Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells.
Ding X, Lin Q, Ensenat-Waser R, Rose-John S, Zenke M
Stem Cells Dev. 2012 Jan;21(1):121-32
 
136
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J
J Biol Chem 2011 Dec 16;286(50):42959-70
 
135
Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.
Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, Hildner K, Hoffman A, Kiesslich R, Rink AD, Rau TT, Rose-John S, Kessler H, Schmidt J, Neurath MF
Gastroenterology. 2011 Dec;141(6):2026-38
 
134
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS
J Clin Invest. 2011 Oct;121(10):3846-59
 
133
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model.
Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH
Crit Care Med. 2011 Jun;39(6):1407-13
 
132
The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution.
Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):515-20
 
131
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, Pappo O, Rose-John S, Galun E, Axelrod JH
J Hepatol. 2011 May;54(5):922-9
 
130
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.
Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P, Rose-John S, Neurath MF, Geissler EK, Schlitt HJ, Strober W, Fichtner-Feigl S
J Clin Invest. 2011 May;121(5):1692-708
 
129
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H
Cancer Cell. 2011 Apr 12;19(4):456-69
 
128
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J
J Biol Chem. 2011 Apr 29;286(17):14804-11
 
127
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Loppnow H, Zhang L, Buerke M, Lautenschläger M, Chen L, Frister A, Schlitt A, Luther T, Song N, Hofmann B, Rose-John S, Silber RE, Müller-Werdan U, Werdan K
J Cell Mol Med. 2011 Apr;15(4):994-1004
 
126
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
Malchow S, Thaiss W, Jänner N, Waetzig GH, Gewiese-Rabsch J, Garbers C, Yamamoto K, Rose-John S, Scheller J
Biochim Biophys Acta. 2011 Mar;1812(3):290-301
 
125
Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis.
Loppnow H, Buerke M, Werdan K, Rose-John S
J Cell Mol Med. 2011 Mar;15(3):484-500
 
124
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ
J Immunol. 2011 Jan 15;186(2):1199-208
 
123
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer.
Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, Chang JS, Lai TC, Rose-John S, Kuo ML, Wei LH
Cancer Res. 2011 Jan 15;71(2):424-34
 
122
ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.
Conrad U, Plagmann I, Malchow S, Sack M, Floss DM, Kruglov AA, Nedospasov SA, Rose-John S, Scheller J
Plant Biotechnol J. 2011 Jan;9(1):22-31
 
121
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF(2010)
J Exp Med. 2010 Dec 20;207(13):2855-68
 
120
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA
Nat Immunol. 2010 Dec;11(12):1119-26
 
119
Role of IL-6 trans-signaling in CCl₄induced liver damage.
Gewiese-Rabsch J, Drucker C, Malchow S, Scheller J, Rose-John S
Biochim Biophys Acta. 2010 Nov;1802(11):1054-61
 
118
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.
Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R
Immunology. 2010 Nov;131(3):395-404
 
 
116
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B
Blood. 2010 Oct 28;116(17):3347-55
 
115
Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6
Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R
J Leukoc Biol. 2010 Sep;88(3):579-87
 
114
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J Exp Med. 2010 Aug 2;207(8):1617-24
 
113
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.
Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J
Mol Biol Cell. 2010 Aug 1;21(15):2797-807. Erratum in: Mol Biol Cell. 2011 Jun;22(12):2132
 
112
Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.
McGreal EP, Davies PL, Powell W, Rose-John S, Spiller OB, Doull I, Jones SA, Kotecha S
Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58
 
111
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J Immunol. 2010 Feb 15;184(4):2130-9
 
 
109
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.
Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J
Biochim Biophys Acta. 2010 Feb;1803(2):234-45
 
108
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D
J Biol Chem. 2010 Jan 15;285(3):1781-9
 
107
TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.
Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell HW, Rose-John S, Engert A, von Strandmann EP, Hansen HP
Leukemia. 2010 Jan;24(1):51-7
 
106
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U
Hepatology. 2009 Dec;50(6):1773-82
 
105
G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation.
Sina C, Gavrilova O, Förster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Häsler R, Nikolaus S, Fölsch UR, Rose-John S, Jiang HP, Li J, Schreiber S, Rosenstiel P
J Immunol. 2009 Dec 1;183(11):7514-22
 
104
Interleukin-6 trans-signaling regulates glycogen consumption after D-galactosamine-induced liver damage.
Drucker C, Rabe B, Chalaris A, Schulz E, Scheller J, Rose-John S
J Interferon Cytokine Res. 2009 Nov;29(11):711-8
 
103
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M
J Neurosci. 2009 Oct 28;29(43):13473-83
 
102
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep.
Benedict C, Scheller J, Rose-John S, Born J, Marshall L
FASEB J. 2009 Oct;23(10):3629-36
 
101
Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.
Plagmann I, Chalaris A, Kruglov AA, Nedospasov S, Rosenstiel P, Rose-John S, Scheller J
J Biotechnol. 2009 Jun 15;142(2):170-8
 
100
IL-6-trans-signalling increases rapid-eye-movement sleep in rats.
May U, Schiffelholz T, Baier PC, Krueger JM, Rose-John S, Scheller J
Eur J Pharmacol. 2009 Jun 24;613(1-3):141-5
 
99
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Baier PC, May U, Scheller J, Rose-John S, Schiffelholz T
Behav Brain Res. 2009 Jun 8;200(1):192-6
 
98
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J
J Virol. 2009 May;83(10):5117-26
 
97
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production.
Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H
Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H987-96
 
96
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M
Cancer Cell. 2009 Feb 3;15(2):103-13
 
95
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, Richards PJ, Slinn S, Ernst M, Jenkins BJ, Topley N, Rose-John S, Jones SA
J Immunol. 2009 Jan 1;182(1):613-22
 
94
Interleukin-6 and neural stem cells: more than gliogenesis.
Islam O, Gong X, Rose-John S, Heese K
Mol Biol Cell. 2009 Jan;20(1):188-99
 
93
Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.
von Bismarck P, Claass A, Schickor C, Krause MF, Rose-John S
Exp Lung Res. 2008 Dec;34(10):694-706
 
92
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier.
Linker RA, Lühder F, Kallen KJ, Lee DH, Engelhardt B, Rose-John S, Gold R
J Neuroimmunol. 2008 Dec 15;205(1-2):64-72
 
91
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130
Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J
J Biol Chem. 2008 Oct 3;283(40):27200-7
 
90
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C
J Cell Biol. 2008 Sep 8;182(5):993-1005
 
89
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis.
Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, Schmidt J, Galle PR, Rose-John S, Neurath MF
J Exp Med. 2008 Sep 1;205(9):2099-110
 
88
The transcription factor repertoire of Flt3+ hematopoietic stem cells.
Hieronymus T, Ruau D, Ober-Blöbaum J, Baek JH, Rolletschek A, Rose-John S, Wobus AM, Müller AM, Zenke M
Cells Tissues Organs. 2008;188(1-2):103-15
 
87
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
Mudter J, Amoussina L, Schenk M, Yu J, Brüstle A, Weigmann B, Atreya R, Wirtz S, Becker C, Hoffman A, Atreya I, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF
J Clin Invest. 2008 Jul;118(7):2415-26
 
86
IL-6/IL-6R axis plays a critical role in acute kidney injury.
Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH
J Am Soc Nephrol. 2008 Jun;19(6):1106-15
 
85
IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.
Marino M, Scuderi F, Provenzano C, Scheller J, Rose-John S, Bartoccioni E
J Neuroimmunol. 2008 May 30;196(1-2):41-8
 
84
Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
Sudarman E, Bollati-Fogolín M, Hafner M, Müller W, Scheller J, Rose-John S, Eichler J
Chem Biol Drug Des. 2008 May;71(5):494-500
 
83
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
Walker F, Zhang HH, Matthews V, Weinstock J, Nice EC, Ernst M, Rose-John S, Burgess AW
Blood. 2008 Apr 15;111(8):3978-85
 
82
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Benrick A, Jirholt P, Wernstedt I, Gustafsson M, Scheller J, Eriksson AL, Borén J, Hedner T, Ohlsson C, Härd T, Rose-John S, Jansson JO
Regul Pept. 2008 Feb 7;146(1-3):189-96
 
81
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J
Blood. 2008 Feb 1;111(3):1021-8
 
80
Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling.
Wei LH, Baumann H, Tracy E, Wang Y, Hutson A, Rose-John S, Henderson BW
Br J Cancer. 2007 Dec 3;97(11):1513-22
 
79
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
Koch M, May U, Kuhns S, Drechsler H, Adam N, Hattermann K, Wirtz S, Rose-John S, Scheller J
Biochem Biophys Res Commun. 2007 Dec 21;364(3):483-7
 
78
Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress.
Appenheimer MM, Girard RA, Chen Q, Wang WC, Bankert KC, Hardison J, Bain MD, Ridgley F, Sarcione EJ, Buitrago S, Kothlow S, Kaspers B, Robert J, Rose-John S, Baumann H, Evans SS
Eur J Immunol. 2007 Oct;37(10):2856-67
 
77
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J
Blood. 2007 Sep 15;110(6):1748-55
 
76
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C
J Immunol. 2007 Aug 15;179(4):2041-5
 
 
74
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF
Int Immunol. 2007 Jun;19(6):685-93
 
73
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.
Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB
Hepatology. 2007 Feb;45(2):486-94
 
72
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP
Cancer Res. 2007 Jan 1;67(1):332-8
 
71
Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.
Chattopadhyay S, Tracy E, Liang P, Robledo O, Rose-John S, Baumann H
J Biol Chem. 2007 Feb 2;282(5):3014-26
 
70
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism.
Chen Q, Fisher DT, Clancy KA, Gauguet JM, Wang WC, Unger E, Rose-John S, von Andrian UH, Baumann H, Evans SS
Nat Immunol. 2006 Dec;7(12):1299-308
 
69
Sleep enhances IL-6 trans-signaling in humans.
Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA, Scheller J, Rose-John S, Born J
FASEB J. 2006 Oct;20(12):2174-6
 
68
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.
Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grötzinger J
Biol Chem. 2006 Sep;387(9):1255-9
 
67
Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display.
Kovaleva M, Bussmeyer I, Rabe B, Grötzinger J, Sudarman E, Eichler J, Conrad U, Rose-John S, Scheller J
J Virol. 2006 Sep;80(17):8510-20
 
 
65
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice.
Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, Handa K, Tsuruta O, Funabashi H, Scheller J, Toyonaga A, Sata M
Gut. 2006 Sep;55(9):1263-9
 
64
gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes.
Tenhumberg S, Schuster B, Zhu L, Kovaleva M, Scheller J, Kallen KJ, Rose-John S
Biochem Biophys Res Commun. 2006 Aug 4;346(3):649-57
 
63
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.
Stuhlmann-Laeisz C, Lang S, Chalaris A, Krzysztof P, Enge S, Eichler J, Klingmüller U, Samuel M, Ernst M, Rose-John S, Scheller J
Mol Biol Cell. 2006 Jul;17(7):2986-95
 
62
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
Watt MJ, Dzamko N, Thomas WG, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio MA, Steinberg GR
Nat Med. 2006 May;12(5):541-8
 
61
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA
Arthritis Rheum. 2006 May;54(5):1662-72
 
60
Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells.
Campard D, Vasse M, Rose-John S, Poyer F, Lamacz M, Vannier JP
Stem Cells. 2006 May;24(5):1302-14
 
59
Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.
Oberg HH, Wesch D, Grüssel S, Rose-John S, Kabelitz D
Int Immunol. 2006 Apr;18(4):555-63
 
58
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K
Mol Cell Biol. 2005 Oct;25(20):9040-53
 
57
Viral IL-6 blocks neutrophil infiltration during acute inflammation.
Fielding CA, McLoughlin RM, Colmont CS, Kovaleva M, Harris DA, Rose-John S, Topley N, Jones SA
J Immunol. 2005 Sep 15;175(6):4024-9
 
56
Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
Obreja O, Biasio W, Andratsch M, Lips KS, Rathee PK, Ludwig A, Rose-John S, Kress M
Brain. 2005 Jul;128(Pt 7):1634-41
 
55
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.
Klein C, Wüstefeld T, Assmus U, Roskams T, Rose-John S, Müller M, Manns MP, Ernst M, Trautwein C
J Clin Invest. 2005 Apr;115(4):860-9
 
54
Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro.
Hieronymus T, Gust TC, Kirsch RD, Jorgas T, Blendinger G, Goncharenko M, Supplitt K, Rose-John S, Müller AM, Zenke M
J Immunol. 2005 Mar 1;174(5):2552-62
 
53
Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.
Schroers A, Hecht O, Kallen KJ, Pachta M, Rose-John S, Grötzinger J
Protein Sci. 2005 Mar;14(3):783-90
 
52
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.
Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, Haddad el-B, Lehr HA, Schmitt E, Bopp T, Kallen KJ, Herz U, Schmitt S, Luft C, Hecht O, Hohlfeld JM, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S
J Clin Invest. 2005 Feb;115(2):313-25. Erratum in: J Clin Invest. 2005 May;115(5):1388. Lehr, Hans A [added]
 
51
IL-6 signaling promotes tumor growth in colorectal cancer.
Becker C, Fantini MC, Wirtz S, Nikolaev A, Lehr HA, Galle PR, Rose-John S, Neurath MF
Cell Cycle. 2005 Feb;4(2):217-20
 
50
No inhibition of IL-27 signaling by soluble gp130
Scheller J, Schuster B, Hölscher C, Yoshimoto T, Rose-John S
Biochem Biophys Res Commun. 2005 Jan 28;326(4):724-8
 
49
Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1
Waetzig GH, Rosenstiel P, Arlt A, Till A, Bräutigam K, Schäfer H, Rose-John S, Seegert D, Schreiber S
FASEB J. 2005 Jan;19(1):91-3
 
48
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF
Immunity. 2004 Oct;21(4):491-501
 
47
Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling.
Curnow SJ, Scheel-Toellner D, Jenkinson W, Raza K, Durrani OM, Faint JM, Rauz S, Wloka K, Pilling D, Rose-John S, Buckley CD, Murray PI, Salmon M
J Immunol. 2004 Oct 15;173(8):5290-7
 
46
Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells.
Matthews VB, Rose-John S, Yeoh GC
Hepatology. 2004 Sep;40(3):759; author reply 760
 
44
Maintenance of pluripotency in human embryonic stem cells is STAT3 independent.
Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo MT, Rose-John S, Hayek A
Stem Cells. 2004;22(4):522-30
 
44
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC, Bulfone-Paus S
J Biol Chem. 2004 Sep 24;279(39):40368-75. Epub 2004 Jun 23. Retraction in: J Biol Chem. 2011 Mar 18;286(11):9894
 
43
Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.
Scheller J, Kovaleva M, Rabe B, Eichler J, Kallen KJ, Rose-John S
J Immunol Methods. 2004 Aug;291(1-2):93-100
 
42
Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons.
März P, Probst A, Lang S, Schwager M, Rose-John S, Otten U, Ozbek S
J Biol Chem. 2004 Aug 20;279(34):35542-50
 
41
1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor.
Schwantner A, Dingley AJ, Ozbek S, Hecht O, Rose-John S, Grötzinger J
J Biomol NMR. 2004 Jul;29(3):407-8
 
40
The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis.
Wang XP, Schunck M, Kallen KJ, Neumann C, Trautwein C, Rose-John S, Proksch E
J Invest Dermatol. 2004 Jul;123(1):124-31
 
39
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A
J Immunol. 2004 May 15;172(10):6362-72
 
38
Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy.
Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J
J Biol Chem. 2004 Jan 2;279(1):571-6
 
37
Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction.
Fuchs M, Hilfiker A, Kaminski K, Hilfiker-Kleiner D, Guener Z, Klein G, Podewski E, Schieffer B, Rose-John S, Drexler H
FASEB J. 2003 Nov;17(14):2118-20
 
36
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen KJ, Rose-John S
J Biol Chem. 2003 Oct 3;278(40):38829-39
 
35
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130
Nowell MA, Richards PJ, Horiuchi S, Yamamoto N, Rose-John S, Topley N, Williams AS, Jones SA
J Immunol. 2003 Sep 15;171(6):3202-9
 
34
Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
J Clin Invest. 2003 Aug;112(4):598-607
 
33
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A
Blood. 2003 Aug 15;102(4):1186-95
 
32
Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines.
Aasland D, Schuster B, Grötzinger J, Rose-John S, Kallen KJ
Biochemistry. 2003 May 13;42(18):5244-52
 
31
Transcriptional profiling identifies Id2 function in dendritic cell development.
Hacker C, Kirsch RD, Ju XS, Hieronymus T, Gust TC, Kuhl C, Jorgas T, Kurz SM, Rose-John S, Yokota Y, Zenke M
Nat Immunol. 2003 Apr;4(4):380-6
 
30
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.
Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, Rose-John S, Kallen KJ
J Biol Chem. 2003 Mar 14;278(11):9528-35
 
29
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane.
Schuster B, Meinert W, Rose-John S, Kallen KJ
FEBS Lett. 2003 Mar 13;538(1-3):113-6
 
28
Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling.
Ju XS, Hacker C, Madruga J, Kurz SM, Knespel S, Blendinger G, Rose-John S, Martin Z
Eur J Cell Biol. 2003 Feb;82(2):75-86
 
27
 
 
25
Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12
Löhr HF, Pingel S, Böcher WO, Bernhard H, Herzog-Hauff S, Rose-John S, Galle PR
Clin Exp Immunol. 2002 Oct;130(1):107-14
 
24
The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons.
Sun Y, März P, Otten U, Ge J, Rose-John S
Biochem Biophys Res Commun. 2002 Jul 12;295(2):532-9
 
23
Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor.
März P, Ozbek S, Fischer M, Voltz N, Otten U, Rose-John S
Eur J Biochem. 2002 Jun;269(12):3023-31
 
22
Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells.
Klouche M, Brockmeyer N, Knabbe C, Rose-John S
AIDS. 2002 May 24;16(8):F9-18
 
21
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6
Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW
Stem Cells. 2002;20(2):119-38
 
 
19
Humoral responses to melanoma vaccine, genetically modified with interleukin 6 and soluble interleukin 6 receptor.
Nawrocki S, Łaciak M, Izycki D, Gryska K, Wysocki PJ, Grabarczyk P, Karczewska A, Kaczmarek A, Murawa P, Malicki J, Rose-John S, Mackiewicz A
Adv Exp Med Biol. 2001;495:411-8
 
 
17
Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.
Böcher WO, Dekel B, Schwerin W, Geissler M, Hoffmann S, Rohwer A, Arditti F, Cooper A, Bernhard H, Berrebi A, Rose-John S, Shaul Y, Galle PR, Löhr HF, Reisner Y
Eur J Immunol. 2001 Jul;31(7):2071-9
 
 
15
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA
Immunity. 2001 Jun;14(6):705-14
 
14
In vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130
Chow D, Ho J, Nguyen Pham TL, Rose-John S, Garcia KC
Biochemistry. 2001 Jun 26;40(25):7593-603
 
13
Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis B virus infection.
Heinz D, Peters M, Prange R, Gerken G, Rose-John S
J Viral Hepat. 2001 May;8(3):186-93
 
12
Hyper-IL-6 gene therapy reverses fulminant hepatic failure.
Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH
Mol Ther. 2001 May;3(5 Pt 1):683-7
 
 
10
Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.
Mann A, Breuhahn K, Schirmacher P, Wilhelmi A, Beyer C, Rosenau A, Ozbek S, Rose-John S, Blessing M
Cancer Res. 2001 Mar 1;61(5):2311-9
 
9
Structure of an extracellular gp130 cytokine receptor signaling complex.
Chow D, He X, Snow AL, Rose-John S, Garcia KC
Science. 2001 Mar 16;291(5511):2150-5
 
8
The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells.
Ozbek S, Peters M, Breuhahn K, Mann A, Blessing M, Fischer M, Schirmacher P, Mackiewicz A, Rose-John S
Oncogene. 2001 Feb 22;20(8):972-9
 
7
Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells.
Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1757-62
 
6
Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.
Althoff K, Müllberg J, Aasland D, Voltz N, Kallen K, Grötzinger J, Rose-John S
Biochem J. 2001 Feb 1;353(Pt 3):663-72
 
5
Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro.
Peters M, Solem F, Goldschmidt J, Schirmacher P, Rose-John S
Exp Hematol. 2001 Feb;29(2):146-55
 
4
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.
Jostock T, Müllberg J, Ozbek S, Atreya R, Blinn G, Voltz N, Fischer M, Neurath MF, Rose-John S
Eur J Biochem. 2001 Jan;268(1):160-7
 
3
Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration.
Peters M, Blinn G, Jostock T, Schirmacher P, Meyer zum Büschenfelde KH, Galle PR, Rose-John S
Gastroenterology. 2000 Dec;119(6):1663-71
 
2
Astrocytic alterations in interleukin-6/Soluble interleukin-6 receptor alpha double-transgenic mice.
Brunello AG, Weissenberger J, Kappeler A, Vallan C, Peters M, Rose-John S, Weis J
Am J Pathol. 2000 Nov;157(5):1485-93
 
1
Generation of tumor-reactive CTL against the tumor-associated antigen HER2 using retrovirally transduced dendritic cells derived from CD34+ hemopoietic progenitor cells.
Meyer zum Büschenfelde C, Nicklisch N, Rose-John S, Peschel C, Bernhard H
J Immunol. 2000 Oct 1;165(7):4133-40
 
 
 
 
51
Necroptosis, ADAM proteases and intestinal (dys)function.
Heib M, Rose-John S, Adam D.
Int Rev Cell Mol Biol. 2020;353:83-152
 
50
ADAM17: An Emerging Therapeutic Target for Lung Cancer.
Saad MI, Rose-John S, Jenkins BJ.
Cancers (Basel). 2019 Aug 21;11(9)
 
49
Interleukin-6: designing specific therapeutics for a complex cytokine.
Garbers C, Heink S, Korn T, Rose-John S.
Nat Rev Drug Discov 2018 Jun;17(6):395-412
 
48
Interleukin-6 Family Cytokines.
Rose-John S.
Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2). pii: a028415
 
47
Proteolytic steps within signaling cascades make these signaling pathways irreversible.
Rose-John S.
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2057-2058
 
46
The shedding protease ADAM17: Physiology and pathophysiology.
Zunke F, Rose-John S.
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2059-2070
 
45
The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation.
Rose-John S.
Clin Pharmacol Ther. 2017 Oct;102(4):591-598
 
44
Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis.
Bender L, Weidmann H, Rose-John S, Renné T, Long AT.
Front Immunol. 2017 Sep 15;8:1115
 
43
The role of IL-6 in host defence against infections: immunobiology and clinical implications.
Rose-John S, Winthrop K, Calabrese L.
Nat Rev Rheumatol. 2017 Jul;13(7):399-409
 
42
The role of interleukin-6 signaling in nervous tissue.
Rothaug M, Becker-Pauly C, Rose-John S.
Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1218-27
 
41
The soluble interleukin-6 receptor and related proteins.
Rose-John S.
Best Pract Res Clin Endocrinol Metab. 2015 Oct;29(5):787-97
 
 
39
Interleukin-6: Biology, signaling and strategies of blockade.
Schaper F, Rose-John S
Cytokine Growth Factor Rev. 2015 Oct;26(5):475-87
 
38
ADAM17, shedding, TACE as therapeutic targets.
Rose-John S
Pharmacol Res. 2013 May;71:19-22
 
37
The regenerative activity of interleukin-6
Galun E, Rose-John S
Methods Mol Biol. 2013;982:59-77
 
 
35
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Chalaris A, Schmidt-Arras D, Yamamoto K, Rose-John S
Dig Dis. 2012;30(5):492-9
 
34
The interleukin 6 pathway and atherosclerosis.
Scheller J, Rose-John S
Lancet. 2012 Jul 28;380(9839):338
 
33
Plasticity and cross-talk of interleukin 6-type cytokines.
Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J
Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97
 
32
Therapeutic blockade of interleukin-6 in chronic inflammatory disease.
Yamamoto K, Rose-John S
Clin Pharmacol Ther. 2012 Apr;91(4):574-6
 
31
Hitting a complex target: an update on interleukin-6 trans-signalling.
Waetzig GH, Rose-John S
Expert Opin Ther Targets. 2012 Feb;16(2):225-36
 
30
Interleukin-6 in sepsis and capillary leakage syndrome.
Krüttgen A, Rose-John S
J Interferon Cytokine Res. 2012 Feb;32(2):60-5
 
29
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.
Jones SA, Scheller J, Rose-John S
J Clin Invest. 2011 Sep;121(9):3375-83
 
28
ADAM17: a molecular switch to control inflammation and tissue regeneration.
Scheller J, Chalaris A, Garbers C, Rose-John S
Trends Immunol. 2011 Aug;32(8):380-7
 
27
Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization.
Suthaus J, Adam N, Grötzinger J, Scheller J, Rose-John S
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):495-504
 
26
The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.
Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J
Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94
 
25
The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S
Biochim Biophys Acta. 2011 May;1813(5):878-88
 
24
Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases?
Febbraio MA, Rose-John S, Pedersen BK
Clin Pharmacol Ther. 2010 Apr;87(4):396-8
 
23
Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration.
Drucker C, Gewiese J, Malchow S, Scheller J, Rose-John S
J Autoimmun. 2010 Feb;34(1):29-37
 
22
Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application.
Floss DM, Schallau K, Rose-John S, Conrad U, Scheller J
Trends Biotechnol. 2010 Jan;28(1):37-45
 
21
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Rose-John S, Mitsuyama K, Matsumoto S, Thaiss WM, Scheller J
Curr Pharm Des. 2009;15(18):2095-103
 
20
The IL-6/sIL-6R complex as a novel target for therapeutic approaches.
Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D
Expert Opin Ther Targets. 2007 May;11(5):613-24
 
19
Cytokines are a therapeutic target for the prevention of inflammation-induced cancers.
Rose-John S, Schooltink H
Recent Results Cancer Res. 2007;174:57-66
 
 
17
Interleukin-6 trans-signaling in inflammatory bowel disease.
Mitsuyama K, Sata M, Rose-John S
Cytokine Growth Factor Rev. 2006 Dec;17(6):451-61
 
16
Interleukin-6 and its receptor: from bench to bedside.
Scheller J, Rose-John S
Med Microbiol Immunol. 2006 Dec;195(4):173-83
 
15
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.
Rose-John S, Scheller J, Elson G, Jones SA
J Leukoc Biol. 2006 Aug;80(2):227-36
 
14
Interleukin-6 trans-signalling in chronic inflammation and cancer.
Scheller J, Ohnesorge N, Rose-John S
Scand J Immunol. 2006 May;63(5):321-9
 
13
IL-6 transsignaling: the in vivo consequences.
Jones SA, Richards PJ, Scheller J, Rose-John S
J Interferon Cytokine Res. 2005 May;25(5):241-53
 
12
Designing cytokine variants by phage-display.
Schooltink H, Rose-John S
Comb Chem High Throughput Screen. 2005 Mar;8(2):173-9
 
11
Virokines in the pathogenesis of cancer: focus on human herpesvirus 8
Klouche M, Carruba G, Castagnetta L, Rose-John S
Ann N Y Acad Sci. 2004 Dec;1028:329-39
 
10
IL-6 trans-signaling: the heat is on.
Rose-John S, Neurath MF
Immunity. 2004 Jan;20(1):2-4
 
9
CDP-870. Celltech/Pfizer
Rose-John S, Schooltink H
Curr Opin Investig Drugs. 2003 May;4(5):588-92
 
8
 
7
The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex.
Jones SA, Rose-John S
Biochim Biophys Acta. 2002 Nov 11;1592(3):251-63
 
6
Cytokines come of age.
Rose-John S
Biochim Biophys Acta. 2002 Nov 11;1592(3):213-4
 
5
GP130 stimulation and the maintenance of stem cells.
Rose-John S
Trends Biotechnol. 2002 Oct;20(10):417-9
 
4
Cytokines as therapeutic drugs.
Schooltink H, Rose-John S
J Interferon Cytokine Res. 2002 May;22(5):505-16
 
3
Signals regulating neurotrophin expression in glial cells.
Otten U, März P, Heese K, Hock C, Kunz D, Rose-John S
Prog Brain Res. 2001;132:545-54
 
2
Cytokines and neurotrophins interact in normal and diseased states.
Otten U, März P, Heese K, Hock C, Kunz D, Rose-John S
Ann N Y Acad Sci. 2000;917:322-30
 
1
New perspectives on the design of cytokines and growth factors.
Kallen KJ, Grötzinger J, Rose-John S
Trends Biotechnol. 2000 Nov;18(11):455-61
 
 
Letzte Änderung / Last change: Mai 20, 2020