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Univ. Prof. Dr. Stefan Rose-John

Stefan Rose-John
Stefan Rose-John
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Molecular Biology of Cytokines

Publications

 
Original Publications
Reviews
 

Selected Original Publications

302
IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.
Escrig A, Canal C, Sanchis P, Fernández-Gayol O, Montilla A, Comes G, Molinero A, Giralt M, Giménez-Llort L, Becker-Pauly C, Rose-John S, Hidalgo J.
Brain Behav Immun. 2019 Aug 8. pii: S0889-1591(19)30150-3. doi: 10.1016/j.bbi.2019.08.005. [Epub ahead of print]
 
301
The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients.
Dos Santos Guilherme M, Stoye NM, Rose-John S, Garbers C, Fellgiebel A, Endres K.
Front Aging Neurosci. 2019 Jul 23;11:182
 
300
Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma.
Scherger AK, Al-Maarri M, Maurer HC, Schick M, Maurer S, Öllinger R, Gonzalez-Menendez I, Martella M, Thaler M, Pechloff K, Steiger K, Sander S, Ruland J, Rad R, Quintanilla-Martinez L, Wunderlich FT, Rose-John S, Keller U.
JCI Insight 2019 Aug 8;4(15)
 
299
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C.
FASEB J. 2019 Aug 9:fj201801371R. doi: 10.1096/fj.201801371R. [Epub ahead of print]
 
298
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.
Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.
Int J Mol Sci. 2019 Jul 26;20(15)
 
297
Interleukin 6 Dependent Synaptic Plasticity in a Social Defeat-Susceptible Prefrontal Cortex Circuit.
Esquivel-Rendón E, Vargas-Mireles J, Cuevas-Olguín R, Miranda-Morales M, Acosta-Mares P, García-Oscos F, Pineda JC, Salgado H, Rose-John S, Atzori M.
Neuroscience 2019 Aug 21;414:280-296
 
296
The ADAM17 Protease Promotes Tobacco Smoke Carcinogen-induced Lung Tumourigenesis.
Saad MI, McLeod L, Yu L, Ebi H, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
Carcinogenesis 2019 Jun 27. pii: bgz123. doi: 10.1093/carcin/bgz123. [Epub ahead of print]
 
295
The IL-6-neutralizing sIL-6R/sgp130 buffer system is disturbed in patients with type 2 diabetes.
Aparicio-Siegmund S, Garbers Y, Flynn CM, Waetzig GH, Gouni-Berthold I, Krone W, Berthold HK, Laudes M, Rose-John S, Garbers C.
Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E411-E420
 
294
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation.
Pavlenko E, Cabron AS, Arnold P, Dobert JP, Rose-John S, Zunke F.
Int J Mol Sci. 2019 May 4;20(9). pii: E2198
 
293
Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3.
Servais FA, Kirchmeyer M, Hamdorf M, Minoungou NWE, Rose-John S, Kreis S, Haan C, Behrmann I.
Mol Ther Nucleic Acids. 2019 Jun 7;16:419-433
 
292
ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury.
Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, Bogie J, Vanmierlo T, Vidal PM, Rose-John S, Gou-Fabregas M, Hendrix S.
Brain Behav Immun. 2019 Mar 6. pii: S0889-1591(18)31201-7
 
291
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.
EMBO Mol Med. 2019 Apr;11(4)
 
290
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Paige E, Clément M, Lareyre F, Sweeting M, Raffort J, Grenier C, Finigan A, Harrison J, Peters JE, Sun BB, Butterworth AS, Harrison SC, Bown MJ, Lindholt JS, Badger SA, Kullo IJ, Powell J, Norman PE, Scott DJA, Bailey MA, Rose-John S, Danesh J, Freitag DF, Paul DS, Mallat Z.
Circ Genom Precis Med. 2019 Feb;12(2):e002413
 
289
Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown.
Quarta S, Mitrić M, Kalpachidou T, Mair N, Schiefermeier-Mach N, Andratsch M, Qi Y, Langeslag M, Malsch P, Rose-John S, Kress M.
FASEB J. 2019 Mar;33(3):4418-4431
 
288
Pharmacologic IL-6Rα inhibition in cholangiocarcinoma promotes cancer cell growth and survival.
Kleinegger F, Hofer E, Wodlej C, Golob-Schwarzl N, Birkl-Toeglhofer AM, Stallinger A, Petzold J,Orlova A, Krassnig S, Reihs R, Niedrist T, Mangge H, Park YN, Thalhammer M, Aigelsreiter A, Lax S, Garbers C, Fickert P, Rose-John S, Moriggl R, Rinner B, Haybaeck J.
Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):308-321
 
287
Correction to: A new multiple trauma model of the mouse.
Fitschen-Oestern S, Lippross S, Klueter T, Weuster M, Varoga D, Tohidnezhad M, Pufe T, Rose-John S, Andruszkow H, Hildebrand F, Steubesand N, Seekamp A, Neunaber C.
BMC Musculoskelet Disord. 2019 Feb 11;20(1):72
 
286
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Paige E, Clément M, Lareyre F, Sweeting M, Raffort J, Grenier C, Finigan A, Harrison J, Peters JE, Sun BB, Butterworth AS, Harrison SC, Bown MJ, Lindholt JS, Badger SA, Kullo IJ, Powell J, Norman PE, Scott DJA, Bailey MA, Rose-John S, Danesh J, Freitag DF, Paul DS, Mallat Z.
Circ Genom Precis Med. 2019 Feb;12(2):e002413
 
285
Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.
Agthe M, Brügge J, Garbers Y, Wandel M, Kespohl B, Arnold P, Flynn CM, Lokau J, Aparicio-Siegmund S, Bretscher C, Rose-John S, Waetzig GH, Putoczki T, Grötzinger J, Garbers C.
Cell rep. 2019 Jan;156(1):145-159.e19
 
284
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice.
Aden K, Bartsch K, Dahl J, Reijns MAM, Esser D, Sheibani-Tezerji R, Sinha A, Wottawa F, Ito G, Mishra N, Knittler K, Burkholder A, Welz L, van Es J, Tran F, Lipinski S, Kakavand N, Boeger C, Lucius R, von Schoenfels W, Schafmayer C, Lenk L, Chalaris A, Clevers H, Röcken C, Kaleta C, Rose-John S, Schreiber S, Kunkel T, Rabe B, Rosenstiel P.
Gastroenterology. 2019 Jan;156(1):145-159.e19
 
283
Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation byproteolytic cleavage.
Prenissl N, Lokau J, Rose-John S, Haybaeck J, Garbers C.
Cytokine. 2019 Feb;114:1-5
 
282
Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T.
J Clin Invest 2018 Nov 1;128(11):5056-5072
 
281
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
Cabron AS, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert JP, Pavlenko E, Schumacher N,Renné T, Taylor PR, Linder S, Rose-John S, Zunke F.
J Immunol 2018 Nov 15;201(10):3106-3118
 
280
Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Nivarthi H, Gordziel C,Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S,Friedrich K, Moriggl R.
Oncotarget 2018 Sep 18;9(73):33865
 
279
Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis.
Stahl FR, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck PC, Brune W, Renné T.
Sci Rep 2018 Oct 4;8(1):14823
 
278
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells.
Lücke K, Yan I, Krohn S, Volmari A, Klinge S, Schmid J, Schumacher V, Steinmetz OM, Rose-John S, Mittrücker HW.
PLoS One 2018 Aug 31;13(8):e0203395
 
277
Interleukin 6 Trans-Signalling and Risk of Future Cardiovascular Events.
Ziegler L, Gajulapuri A, Frumento P, Bonomi A, Wallén H, de Faire U, Rose-John S, Gigante B.
Cardiovasc Res 2019 Jan 1;115(1):213-221
 
276
Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice.
Holz K, Prinz M, Brendecke SM, Hölscher A, Deng F, Mitrücker HW, Rose-John S, Hölscher C.
Front Immunol 2018 May 2;9:836
 
275
The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpectedfunction of ADAM-17 in necroptosis.
Fuchslocher Chico J, Falk-Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, Schmidt-Arras D, Linkermann A, Becker C, Rosenstiel P, Rose-John S, Adam D.
Oncotarget 2018 Feb 5;9(16):12941-12958
 
274
Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.
Kaiser K, Prystaz K, Vikman A, Haffner-Luntzer M, Bergdolt S, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Naunyn Schmiedebergs Arch Pharmacol 2018 May;391(5):523-536
 
273
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.
J Exp Med 2018 Apr 2;215(4):1205-1225
 
272
BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.
Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K.
J Clin Invest 2018 Mar 1;128(3):916-930
 
271
Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer.
Garbers C, Rose-John S.
Methods Mol Biol. 2018;1725:127-140
 
270
The ADAM17 Metalloproteinase Maintains Arterial Elasticity.
Nicolaou A, Northoff BH, Zhao Z, Kohlmaier A, Sass K, Rose-John S, Steffens S, Weber C, Teupser D, Holdt LM.
Thromb Haemost 2018 Jan;118(1):210-213
 
269
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.
Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.
Oncoimmunology 2017 Oct 26;7(1):e1368603
 
268
Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C.
Front Immunol. 2017 Nov 10;8:1537
 
267
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.
Prystaz K, Kaiser K, Kovtun A, Haffner-Luntzer M, Fischer V, Rapp AE, Liedert A, Strauss G, Waetzig GH, Rose-John S, Ignatius A.
Am J Pathol. 2018 Feb;188(2):474-490
 
266
Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.
Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.
Front Physiol. 2017 Oct 9;8:775
 
265
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C.
Oncotarget 2017 Jul 4;8(33):54873-54888
 
264
Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.
Dixit A, Bottek J, Beerlage AL, Schuettpelz J, Thiebes S, Brenzel A, Garbers C, Rose-John S, Mittrücker HW, Squire A, Engel DR.
J Leukoc Biol. 2018 Jan;103(1):13-22
 
263
The role of ADAM17 in the T-cell response against bacterial pathogens.
Link MA, Lücke K, Schmid J, Schumacher V, Eden T, Rose-John S, Mittrücker HW.
PLoS One. 2017 Sep 6;12(9):e0184320
 
262
Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.
Kammoun HL, Allen TL, Henstridge DC, Kraakman MJ, Peijs L, Rose-John S, Febbraio MA.
PLoS One. 2017 Jun 20;12(6):e0179099
 
261
IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.
Timper K, Denson JL, Steculorum SM, Heilinger C, Engström-Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT, Brüning JC.
Cell Rep. 2017 Apr 11;19(2):267-280
 
260
EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.
Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.
Gastroenterology 2017 Jul;153(1):178-190.e10
 
259
The balance between Treg and TH17 cells: CD11b and interleukin-6.
Garbers C, Rose-John S.
Eur J Immunol. 2017 Apr;47(4):629-632
 
258
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.
Sci Rep. 2017 Mar 9;7:44053
 
257
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice.
Tode J, Richert E, Koinzer S, Klettner A, Pickhinke U, Garbers C, Rose-John S, Nölle B, Roider J.
Cytokine. 2017 Aug;96:8-15
 
256
Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Balic JJ, Garbers C, Rose-John S, Yu L, Jenkins BJ.
Cytokine. 2017 Apr;92:118-123
 
255
Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.
Sontag S, Förster M, Qin J, Wanek P, Mitzka S, Schüler HM, Koschmieder S, Rose-John S, Seré K, Zenke M.
Stem Cells. 2017 Apr;35(4):898-908
 
254
Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM.
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):247-257
 
253
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.
PLoS Biol. 2017 Jan 6;15(1):e2000080
 
252
IL6-Dependent Genomic Instability Heralds Accelerated Carcinogenesis Following Liver Regeneration on a Background of Chronic Hepatitis.
Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, Rosenberg N, Paldor M, Goldenberg D, Sonnenblick A, Peled A, Rose-John S, Galun E, Axelrod JH.
Hepatology. 2017 May;65(5):1600-1611
 
251
Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.
Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose-John S, Knolle PA, Wohlleber D.
J Hepatol. 2017 May;66(5):978-986
 
250
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.
Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.
Nat Immunol. 2017 Jan;18(1):74-85
 
249
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.
Aden K, Breuer A, Rehman A, Geese H, Tran F, Sommer J, Waetzig GH, Reinheimer TM, Schreiber S, Rose-John S, Scheller J, Rosenstiel P.
Oncogenesis. 2016 Nov 21;5(11):e270
 
248
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D.
Hepatology. 2017 Jan;65(1):89-103
 
247
Instructive Role of the Microenvironment in Preventing Renal Fibrosis.
Matsumoto K, Xavier S, Chen J, Kida Y, Lipphardt M, Ikeda R, Gevertz A, Caviris M, Hatzopoulos AK, Kalajzic I, Dutton J, Ratliff BB, Zhao H, Darzynkiewicz Z, Rose-John S, Goligorsky MS.
Stem Cells Transl Med. 2017 Mar;6(3):992-1005
 
246
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.
Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.
J Immunol. 2016 Nov 1;197(9):3705-3715
 
245
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Kalinin DV, Wagner S, Riemann B, Hermann S, Schmidt F, Becker-Pauly C, Rose-John S, Schäfers M, Holl R.
J Med Chem. 2016 Oct 27;59(20):9541-9559
 
244
Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth.
Burger R, Günther A, Klausz K, Staudinger M, Peipp M, Penas EM, Rose-John S, Wijdenes J, Gramatzki M.
Haematologica. 2017 Feb;102(2):381-390
 
243
ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A.
JCI Insight. 2016 Aug 18;1(13)
 
242
Parathyroid hormone induces expression and proteolytic processing of Rankl in primary murine osteoblasts.
Heckt T, Keller J, Peters S, Streichert T, Chalaris A, Rose-John S, Mell B, Joe B, Amling M, Schinke T.
Bone. 2016 Nov;92:85-93
 
241
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response.
Heim D, Gil-Ibanez I, Herden J, Parplys AC, Borgmann K, Schmidt-Arras D, Lohse AW, Rose-John S, Wege H.
Oncotarget. 2016 Aug 23;7(34):55639-55648
 
240
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A.
Elife. 2016 Aug 1;5
 
239
Therapeutic Targeting of the IL-6 Trans-Signaling/Mechanistic Target of Rapamycin Complex 1 Axis in Pulmonary Emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, Alhayyani S, Tate MD, Deswaerte V, Brooks GD, Bozinovski S, MacDonald M, Garbers C, King PT, Bardin PG, Vlahos R, Rose-John S, Anderson GP, Jenkins BJ.
Am J Respir Crit Care Med. 2016 Dec 15;194(12):1494-1505
 
238
Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.
Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C.
J Biol Chem. 2016 Jul 29;291(31):16186-96
 
237
Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.
Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.
Sci Rep. 2016 May 6;6:25550
 
236
Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts.
Malysheva K, de Rooij K, Lowik CW, Baeten DL, Rose-John S, Stoika R, Korchynskyi O.
Croat Med J. 2016 Apr 23;57(2):89-98
 
235
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia.
Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, White JC, Nazimuddin F, Wertheim G, Levine BL, June CH, Porter DL, Grupp SA.
Cancer Discov. 2016 Jun;6(6):664-79
 
234
Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.
Wörmann SM, Song L, Ai J, Diakopoulos KN, Kurkowski MU, Görgülü K, Ruess D, Campbell A, Doglioni C, Jodrell D, Neesse A, Demir IE, Karpathaki AP, Barenboim M, Hagemann T, Rose-John S, Sansom O, Schmid RM, Protti MP, Lesina M, Algül H.
Gastroenterology. 2016 Jul;151(1):180-193.e12
 
233
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D.
Oncotarget. 2016 Apr 5;7(14):17431-41.
 
232
Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA.
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3006-11
 
231
KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.
Rosean TR, Holman CJ, Tompkins VS, Jing X, Krasowski MD, Rose-John S, Janz S.
Blood Cancer J. 2016 Feb 26;6:e398
 
230
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.
Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.
Cell Rep. 2016 Feb 23;14(7):1761-1773
 
229
A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing.
Wolf J, Waetzig GH, Reinheimer TM, Scheller J, Rose-John S, Garbers C.
Biochem Biophys Res Commun. 2016 Feb 19;470(4):870-6
 
228
Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation.
Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, Eliashar R, Mizrachi L, Orfaig-Geva C, Baum BJ, Rose-John S, Galun E, Axelrod JH.
Cancer Res. 2016 Mar 1;76(5):1170-80
 
227
IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.
Brooks GD, McLeod L, Alhayyani S, Miller A, Russell PA, Ferlin W, Rose-John S, Ruwanpura S, Jenkins BJ.
Cancer Res. 2016 Feb 15;76(4):866-76
 
226
Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.
Birner P, Heider S, Petzelbauer P, Wolf P, Kornauth C, Kuroll M, Merkel O, Steiner G, Kishimoto T, Rose-John S, Soleiman A, Moriggl R, Kenner L.
Exp Dermatol. 2016 Apr;25(4):305-10
 
225
Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells.
Holmer R, Wätzig GH, Tiwari S, Rose-John S, Kalthoff H.
BMC Cancer. 2015 Dec 16;15:975.
 
224
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.
J Leukoc Biol. 2016 May;99(5):749-60
 
223
RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.
Mittelberger F, Meyer C, Waetzig GH, Zacharias M, Valentini E, Svergun DI, Berg K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U.
RNA Biol. 2015;12(9):1043-53
 
222
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.
Schumacher N, Meyer D, Mauermann A, von der Heyde J, Wolf J, Schwarz J, Knittler K, Murphy G, Michalek M, Garbers C, Bartsch JW, Guo S, Schacher B, Eickholz P, Chalaris A, Rose-John S, Rabe B.
J Biol Chem. 2015 Oct 23;290(43):26059-71
 
221
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
Kreins AY, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT, Halwani R, Grant AV, Boisson B, Bogunovic D, Itan Y, Moncada-Velez M, Martinez-Barricarte R, Migaud M, Deswarte C, Alsina L, Kotlarz D, Klein C, Muller-Fleckenstein I, Fleckenstein B, Cormier-Daire V, Rose-John S, Picard C, Hammarstrom L, Puel A, Al-Muhsen S, Abel L, Chaussabel D, Rosenzweig SD, Minegishi Y, Tangye SG, Bustamante J, Casanova JL, Boisson-Dupuis S.
J Exp Med. 2015 Sep 21;212(10):1641-62
 
220
STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.
Nat Commun. 2015 Jul 22;6:7736
 
219
A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.
Hong SS, Choi JH, Lee SY, Park YH, Park KY, Lee JY, Kim J, Gajulapati V, Goo JI, Singh S, Lee K, Kim YK, Im SH, Ahn SH, Rose-John S, Heo TH, Choi Y.
J Immunol. 2015 Jul 1;195(1):237-45
 
218
Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma.
Mackiewicz J, Karczewska-Dzionk A, Laciak M, Kapcinska M, Wiznerowicz M, Burzykowski T, Zakowska M, Rose-John S, Mackiewicz A.
Medicine (Baltimore). 2015 May;94(21):e853
 
217
Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
Grill M, Syme TE, Noçon AL, Lu AZ, Hancock D, Rose-John S, Campbell IL
Glia 63(10):1738-52
 
216
Batf-dependent Th17 cells critically regulate IL-23 driven colitis-associated colon cancer.
Punkenburg E, Vogler T, Büttner M, Amann K, Waldner M, Atreya R, Abendroth B, Mudter J, Merkel S, Gallmeier E, Rose-John S, Neurath MF, Hildner K
Gut 65(7):1139-50
 
215
IL-6 Trans-Signaling Drives Murine Crescentic GN.
Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J
J Am Soc Nephrol 27(1):132-42
 
214
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.
Beyer C, Huang J, Beer J, Zhang Y, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Maier C, Munoz L, Krönke G, Uderhardt S, Distler O, Jones S, Rose-John S, Oravecz T, Schett G, Distler JH
Ann Rheum Dis 74(6):1317-24
 
213
IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans.
Müller N, Schulte DM, Türk K, Freitag-Wolf S, Hampe J, Zeuner R, Schröder JO, Gouni-Berthold I, Berthold HK, Krone W, Rose-John S, Schreiber S, Laudes M
J Lipid Res 56(5):1034-42
 
212
Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.
Ullah MA, Revez JA, Loh Z, Simpson J, Zhang V, Bain L, Varelias A, Rose-John S, Blumenthal A, Smyth MJ, Hill GR, Sukkar MB, Ferreira MA, Phipps S
J Allergy Clin Immunol 137(5):1035-46
 
211
Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.
Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, EstevezE, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S,Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A,Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA
Cell Metab 21(3):403-16
 
210
Activation of the anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic inhibition in the temporal cortex of the rat.
Garcia-Oscos F, Peña D, Housini M, Cheng D, Lopez D, Cuevas-Olguin R, Saderi N, Salgado Delgado R, Galindo Charles L, Salgado Burgos H, Rose-John S, Flores G, Kilgard MP, Atzori M
J Neurosci Res 93(6):859-65
 
209
Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer.
Goumas FA, Holmer R, Egberts JH, Gontarewicz A, Heneweer C, Geisen U, Hauser C, Mende MM, Legler K, Röcken C, Becker T, Waetzig GH, Rose-John S, Kalthoff H
Int J Cancer 137(5):1035-46
 
208
Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome.
Garbers C, Rose-John S
J Proteome Res 14(2):1330-2
 
207
Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.
van der Vorst EP, Jeurissen M, Wolfs IM, Keijbeck A, Theodorou K, Wijnands E, Schurgers L, Weber S, Gijbels MJ, Hamers AA, Dreymueller D, Rose-John S, de Winther MP, Ludwig A, Saftig P, Biessen EA, Donners MM
Am J Pathol 185(4):1145-55
 
206
Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM.
J Am Soc Nephrol 26(7):1597-607
 
205
ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis.
Caolo V, Swennen G, Chalaris A, Wagenaar A, Verbruggen S, Rose-John S, Molin DG, Vooijs M, Post MJ
Angiogenesis 18(1):13-22
 
204
Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M.
Hsu MP, Frausto R, Rose-John S, Campbell IL
Glia 63(1):132-41
 
203
Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex.
Garcia-Oscos F, Peña D, Housini M, Cheng D, Lopez D, Borland MS, Salgado-Delgado R, Salgado H, D'Mello S, Kilgard MP, Rose-John S, Atzori M
Brain Behav Immun 43:149-58
 
202
Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease.
Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reißig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T
Arterioscler Thromb Vasc Biol 34(12):2658-68
 
201
Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.
Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C
PLoS One 9(9):e107990
 
200
Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6.
Reif A, Siebenhaar S, Tröster A, Schmälzlein M, Lechner C, Velisetty P, Gottwald K, Pöhner C, Boos I, Schubert V, Rose-John S, Unverzagt C
Angew Chem Int Ed Engl 53(45):12125-31
 
199
GP130 activation induces myeloma and collaborates with MYC.
Dechow T, Steidle S, Götze KS, Rudelius M, Behnke K, Pechloff K, Kratzat S, Bullinger L, Fend F, Soberon V, Mitova N, Li Z, Thaler M, Bauer J, Pietschmann E, Albers C, Grundler R, Schmidt-Supprian M, Ruland J, Peschel C, Duyster J, Rose-John S, Bassermann F, Keller U
J Clin Invest 124(12):5263-74
 
198
Mycobacterium simiae infection in two unrelated patients with different forms of inherited IFN-γR2 deficiency.
Martínez-Barricarte R, Megged O, Stepensky P, Casimir P, Moncada-Velez M, Averbuch D, Assous MV, Abuzaitoun O, Kong XF, Pedergnana V, Deswarte C, Migaud M, Rose-John S, Itan Y, Boisson B, Belkadi A, Conti F, Abel L, Vogt G, Boisson-Dupuis S, Casanova JL, Bustamante J
J Clin Immunol 34(8):904-9
 
197
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.
Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF
Cell Metab 20(3):433-47
 
196
Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.
Quarta S, Baeumer BE, Scherbakov N, Andratsch M, Rose-John S, Dechant G, Bandtlow CE, Kress M
J Neurosci 34(39):13222-33
 
195
Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.
Effenberger T, von der Heyde J, Bartsch K, Garbers C, Schulze-Osthoff K, Chalaris A, Murphy G, Rose-John S, Rabe B
FASEB J 28(11):4847-56
 
194
The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.
Marczynska J, Ozga A, Wlodarczyk A, Majchrzak-Gorecka M, Kulig P, Banas M, Michalczyk-Wetula D, Majewski P, Hutloff A, Schwarz J, Chalaris A, Scheller J, Rose-John S, Cichy J
J Immunol 193(6):2753-63
 
193
IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.
Böttcher JP, Schanz O, Garbers C, Zaremba A, Hegenbarth S, Kurts C, Beyer M, Schultze JL, Kastenmüller W, Rose-John S, Knolle PA
Cell Rep 8(5):1318-27
 
192
RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.
Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N
Cardiovasc Res 103(2):206-16
 
191
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J
Biochim Biophys Acta 1842(9):1485-94
 
190
Dendritic cell development requires histone deacetylase activity.
Chauvistré H, Küstermann C, Rehage N, Klisch T, Mitzka S, Felker P, Rose-John S, Zenke M, Seré KM
Eur J Immunol 44(8):2478-88
 
189
The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).
Wagener EM, Aurich M, Aparicio-Siegmund S, Floss DM, Garbers C, Breusing K, Rabe B, Schwanbeck R, Grötzinger J, Rose-John S, Scheller J
J Biol Chem 289(26):18442-50
 
188
A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.
Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J
J Biol Chem 289(23):16336-48
 
187
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.
Schlecker E, Fiegler N, Arnold A, Altevogt P, Rose-John S, Moldenhauer G, Sucker A, Paschen A, von Strandmann EP, Textor S, Cerwenka A
Cancer Res 74(13):3429-40
 
186
Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.
Chow SZ, Speck M, Yoganathan P, Nackiewicz D, Hansen AM, Ladefoged M, Rabe B, Rose-John S, Voshol PJ, Lynn FC, Herrera PL, Müller W, Ellingsgaard H, Ehses JA
Diabetes 63(9):2984-95
 
185
Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.
Aparicio-Siegmund S, Sommer J, Monhasery N, Schwanbeck R, Keil E, Finkenstädt D, Pfeffer K, Rose-John S, Scheller J, Garbers C
Oncotarget 5(8):2131-48
 
184
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J
J Neurosci 34(7):2503-13
 
183
Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.
Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A
J Biol Chem289(5):3080-93
 
182
Oncogenic deletion mutants of gp130 signal from intracellular compartments.
Schmidt-Arras D, Müller M, Stevanovic M, Horn S, Schütt A, Bergmann J, Wilkens R, Lickert A, Rose-John S
J Cell Sci 127(Pt 2):341-53
 
181
IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions.
Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A
J Invest Dermatol 134(3):728-35
 
180
Stabilized Interleukin-6 receptor binding RNA aptamers.
Meyer C, Berg K, Eydeler-Haeder K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U
RNA Biol 11(1):57-65
 
179
Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.
Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J
Biochim Biophys Acta 1843(2):275-87
 
178
"Activated" STAT proteins: a paradoxical consequence of inhibited JAK-STAT signaling in cytomegalovirus-infected cells.
Trilling M, Le VT, Rashidi-Alavijeh J, Katschinski B, Scheller J, Rose-John S, Androsiac GE, Jonjic S, Poli V, Pfeffer K, Hengel H
J Immunol 192(1):447-58
 
177
T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
Dewitz C, Möller-Hackbarth K, Schweigert O, Reiss K, Chalaris A, Scheller J, Rose-John S
FEBS J 281(1):157-74
 
176
ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.
Vidal PM, Lemmens E, Avila A, Vangansewinkel T, Chalaris A, Rose-John S, Hendrix S
Cell Death Dis 12;4:e954
 
175
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A
Biochim Biophys Acta 1833(12):3355-67
 
174
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3).
Möller-Hackbarth K, Dewitz C, Schweigert O, Trad A, Garbers C, Rose-John S, Scheller J
J Biol Chem 288(48):34529-44
 
173
Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets.
Marino M, Scuderi F, Ponte E, Maiuri MT, De Cristofaro R, Provenzano C, Rose-John S, Cittadini A, Bartoccioni E
J Biol Regul Homeost Agents 27(3):841-52
 
172
Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
J Immunol 191(11):5574-82
 
171
Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).
Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J
Cell Cycle 12(21):3421-32
 
170
Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions.
Martin P, Palmer G, Vigne S, Lamacchia C, Rodriguez E, Talabot-Ayer D, Rose-John S, Chalaris A, Gabay C
J Leukoc Biol 94(4):791-802
 
169
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice.
Tsantikos E, Maxwell MJ, Putoczki T, Ernst M, Rose-John S, Tarlinton DM, Hibbs ML.
Arthritis Rheum 65(10):2691-702
 
168
Trp53 deficiency protects against acute intestinal inflammation.
Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.
J Immunol 191(2):837-47.
 
167
An analysis of the function and expression of D6 on lymphatic endothelial cells.
McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ
Blood 121(18):3768-77
 
166
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H
J Clin Invest 123(3):1019-31
 
165
In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, Shriki A, Klaus S, Rosen S, Rose-John S, Galun E, Axelrod JH, Heyman SN
Clin Exp Pharmacol Physiol 40(4):262-72
 
164
The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model.
Wei LH, Chou CH, Chen MW, Rose-John S, Kuo ML, Chen SU, Yang YS
J Clin Endocrinol Metab 98(3):E472-84
 
163
gp130 activation is regulated by D2-D3 interdomain connectivity.
Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D
Biochem J 450(3):487-96
 
162
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, Engel DR, Scheller J, Rose-John S, Mittrücker HW
J Immunol 190(2):703-11
 
161
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C
Cell Mol Life Sci 70(2):309-33
 
160
d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers.
Magbanua E, Zivkovic T, Hansen B, Beschorner N, Meyer C, Lorenzen I, Grötzinger J, Hauber J, Torda AE, Mayer G, Rose-John S, Hahn U
RNA Biol 10(2):216-27
 
159
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.
Braun O, Dewitz C, Möller-Hackbarth K, Scheller J, Schiffelholz T, Baier PC, Rose-John S (2013)
J Interferon Cytokine Res 33(5):254-60
 
158
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, Rose-John S, Grötzinger J, Lorenzen I, Scheller J
J Biol Chem 288(6):4346-54
 
157
Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction.
Samavedam UK, Kalies K, Scheller J, Sadeghi H, Gupta Y, Jonkman MF, Schmidt E, Westermann J, Zillikens D, Rose-John S, Ludwig RJ
J Autoimmun 40:74-85
 
156
ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.
Trad A, Hansen HP, Shomali M, Peipp M, Klausz K, Hedemann N, Yamamoto K, Mauermann A, Desel C, Lorenzen I, Lemke H, Rose-John S, Grötzinger J
Cancer Immunol Immunother 62(3):411-21
 
155
mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.
Derer S, Till A, Haesler R, Sina C, Grabe N, Jung S, Nikolaus S, Kuehbacher T, Groetzinger J, Rose-John S, Rosenstiel PC, Schreiber S
Gut 62(3):376-86
 
154
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B
J Thromb Haemost 10(12):2581-92
 
153
Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.
ElSharawy A, Warner J, Olson J, Forster M, Schilhabel MB, Link DR, Rose-John S, Schreiber S, Rosenstiel P, Brayer J, Franke A
BMC Genomics 13:500
 
152
Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis.
Gerlach K, Daniel C, Lehr HA, Nikolaev A, Gerlach T, Atreya R, Rose-John S, Neurath MF, Weigmann B
Cancer Res 72(17):4340-50
 
151
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.
O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE
EMBO Mol Med 4(9):939-51
 
150
Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection.
Mackiewicz A, Mackiewicz J, Wysocki PJ, Wiznerowicz M, Kapcinska M, Laciak M, Rose-John S, Izycki D, Burzykowski T, Karczewska-Dzionk A
Expert Opin Investig Drugs 21(6):773-83
 
149
The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.
Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J
FEBS Lett 586(8):1093-100
 
148
Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.
Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, Rose-John S, Scheller J, Thiery J, Kratzsch J.
PLoS One 7(4):e34787
 
147
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Sommer J, Effenberger T, Volpi E, Waetzig GH, Bernhardt M, Suthaus J, Garbers C, Rose-John S, Floss DM, Scheller J
J Biol Chem 287(17):13743-51
 
146
A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.
Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S
Biochem J 445(1):135-44
 
145
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, Janz S, Scheller J, Rose-John S (2012)
Blood 119(22):5173-81
 
144
A designer hyper interleukin 11 (H11) is a biologically active cytokine.
Dams-Kozlowska H, Gryska K, Kwiatkowska-Borowczyk E, Izycki D, Rose-John S, Mackiewicz A
BMC Biotechnol 12:8
 
143
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis.
Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John S, Ehlers S, Hölscher C
Immunobiology 217(10):996-1004
 
142
Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells.
Meyer C, Eydeler K, Magbanua E, Zivkovic T, Piganeau N, Lorenzen I, Grötzinger J, Mayer G, Rose-John S, Hahn U
RNA Biol 9(1):67-80
 
141
The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling.
Garcia-Oscos F, Salgado H, Hall S, Thomas F, Farmer GE, Bermeo J, Galindo LC, Ramirez RD, D'Mello S, Rose-John S, Atzori M
Biol Psychiatry 71(7):574-82
 
140
IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.
Traum D, Timothee P, Silver J, Rose-John S, Ernst M, LaRosa DF
J Leukoc Biol 91(3):427-35
 
139
Dendritic cell lineage commitment is instructed by distinct cytokine signals.
Seré KM, Lin Q, Felker P, Rehage N, Klisch T, Ortseifer I, Hieronymus T, Rose-John S, Zenke M
Eur J Cell Biol 91(6-7):515-23
 
138
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, Wollert KC, Seegert D, Rose-John S, Tietge UJ, Schieffer B, Grote K
Arterioscler Thromb Vasc Biol 2012 Feb;32(2):281-90
 
137
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J
J Biol Chem 2011 Dec 16;286(50):42959-70
 
136
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS
J Clin Invest 121(10):3846-59
 
135
Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.
Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, Hildner K, Hoffman A, Kiesslich R, Rink AD, Rau TT, Rose-John S, Kessler H, Schmidt J, Neurath MF
Gastroenterology 141(6):2026-38
 
134
Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells.
Ding X, Lin Q, Ensenat-Waser R, Rose-John S, Zenke M
Stem Cells Dev 21(1):121-32
 
133
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.
Schiechl G, Bauer B, Fuss I, Lang SA, Moser C, Ruemmele P, Rose-John S, Neurath MF, Geissler EK, Schlitt HJ, Strober W, Fichtner-Feigl S
J Clin Invest 121(5):1692-708
 
132
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H
Cancer Cell 19(4):456-69
 
131
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J
J Biol Chem 286(17):14804-11
 
130
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model.
Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH
Crit Care Med 39(6):1407-13
 
129
Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis.
Loppnow H, Buerke M, Werdan K, Rose-John S
J Cell Mol Med 15(3):484-500
 
128
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ
J Immunol 186(2):1199-208
 
127
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, Pappo O, Rose-John S, Galun E, Axelrod JH
J Hepatol 54(5):922-9
 
126
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
Malchow S, Thaiss W, Jänner N, Waetzig GH, Gewiese-Rabsch J, Garbers C, Yamamoto K, Rose-John S, Scheller J
Biochim Biophys Acta 1812(3):290-301
 
125
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer.
Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, Chang JS, Lai TC, Rose-John S, Kuo ML, Wei LH
Cancer Res 71(2):424-34
 
124
ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.
Conrad U, Plagmann I, Malchow S, Sack M, Floss DM, Kruglov AA, Nedospasov SA, Rose-John S, Scheller J
Plant Biotechnol J 9(1):22-31
 
123
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Loppnow H, Zhang L, Buerke M, Lautenschläger M, Chen L, Frister A, Schlitt A, Luther T, Song N, Hofmann B, Rose-John S, Silber RE, Müller-Werdan U, Werdan K
J Cell Mol Med 15(4):994-1004
 
122
The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution.
Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J
Eur J Cell Biol 90(6-7):515-20
 
121
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF(2010)
J Exp Med207(13):2855-68
 
120
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA
Nat Immunol 11(12):1119-26
 
119
Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.
Lam SP, Luk JM, Man K, Ng KT, Cheung CK, Rose-John S, Lo CM
Liver Transpl 2010 Oct;16(10):1195-206
 
118
Role of IL-6 trans-signaling in CCl₄induced liver damage.
Gewiese-Rabsch J, Drucker C, Malchow S, Scheller J, Rose-John S
Biochim Biophys Acta 1802(11):1054-61
 
117
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B
Blood 116(17):3347-55
 
116
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J Exp Med 207(8):1617-24
 
115
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.
Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R
Immunology 131(3):395-404
 
114
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.
Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J
Mol Biol Cell 21(15):2797-807
 
113
Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6
Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R
J Leukoc Biol 88(3):579-87
 
112
Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.
McGreal EP, Davies PL, Powell W, Rose-John S, Spiller OB, Doull I, Jones SA, Kotecha S
Biochim Biophys Acta 1802(7-8):649-58
 
111
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J Immunol 184(4):2130-9
 
110
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T
J Immunol 184(3):1543-51
 
109
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.
Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J
Biochim Biophys Acta 1803(2):234-45
 
108
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U
Hepatology 50(6):1773-82
 
107
G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation.
Sina C, Gavrilova O, Förster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Häsler R, Nikolaus S, Fölsch UR, Rose-John S, Jiang HP, Li J, Schreiber S, Rosenstiel P
J Immunol 183(11):7514-22
 
106
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130
Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Vallés Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D
J Biol Chem 285(3):1781-9
 
105
TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.
Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell HW, Rose-John S, Engert A, von Strandmann EP, Hansen HP
Leukemia 24(1):51-7
 
104
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M
J Neurosci 29(43):13473-83
 
103
Interleukin-6 trans-signaling regulates glycogen consumption after D-galactosamine-induced liver damage.
Drucker C, Rabe B, Chalaris A, Schulz E, Scheller J, Rose-John S
J Interferon Cytokine Res 29(11):711-8
 
102
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep.
Benedict C, Scheller J, Rose-John S, Born J, Marshall L
FASEB J 3(10):3629-36
 
101
Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.
Plagmann I, Chalaris A, Kruglov AA, Nedospasov S, Rosenstiel P, Rose-John S, Scheller J
J Biotechnol 142(2):170-8
 
100
IL-6-trans-signalling increases rapid-eye-movement sleep in rats.
May U, Schiffelholz T, Baier PC, Krueger JM, Rose-John S, Scheller J
Eur J Pharmacol 613(1-3):141-5
 
99
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Baier PC, May U, Scheller J, Rose-John S, Schiffelholz T
Behav Brain Res 200(1):192-6
 
98
Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
J Virol 83(10):5117-26
 
97
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M
Cancer Cell 15(2):103-13
 
96
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production.
Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H
Am J Physiol Heart Circ Physiol 296(4):H987-96
 
95
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, Richards PJ, Slinn S, Ernst M, Jenkins BJ, Topley N, Rose-John S, Jones SA
J Immunol 182(1):613-22
 
94
Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.
von Bismarck P, Claass A, Schickor C, Krause MF, Rose-John S
Exp Lung Res 34(10):694-706
 
93
Interleukin-6 and neural stem cells: more than gliogenesis.
Islam O, Gong X, Rose-John S, Heese K
Mol Biol Cell 20(1):188-99
 
92
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier.
Linker RA, Lühder F, Kallen KJ, Lee DH, Engelhardt B, Rose-John S, Gold R
J Neuroimmunol 205(1-2):64-72
 
91
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C
J Cell Biol 182(5):993-1005
 
90
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis.
Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, Schmidt J, Galle PR, Rose-John S, Neurath MF
J Exp Med 205(9):2099-110
 
89
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130
Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J
J Biol Chem 283(40):27200-7
 
88
The transcription factor repertoire of Flt3+ hematopoietic stem cells.
Hieronymus T, Ruau D, Ober-Blöbaum J, Baek JH, Rolletschek A, Rose-John S, Wobus AM, Müller AM, Zenke M
Cells Tissues Organs 188(1-2):103-15
 
87
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
Mudter J, Amoussina L, Schenk M, Yu J, Brüstle A, Weigmann B, Atreya R, Wirtz S, Becker C, Hoffman A, Atreya I, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF
J Clin Invest 118(7):2415-26
 
86
IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.
Marino M, Scuderi F, Provenzano C, Scheller J, Rose-John S, Bartoccioni E
J Neuroimmunol 196(1-2):41-8
 
85
Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
Sudarman E, Bollati-Fogolín M, Hafner M, Müller W, Scheller J, Rose-John S, Eichler J
Chem Biol Drug Des 71(5):494-500
 
84
IL-6/IL-6R axis plays a critical role in acute kidney injury.
Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH
J Am Soc Nephrol 19(6):1106-15
 
83
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
Walker F, Zhang HH, Matthews V, Weinstock J, Nice EC, Ernst M, Rose-John S, Burgess AW
Blood 111(8):3978-85
 
82
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Benrick A, Jirholt P, Wernstedt I, Gustafsson M, Scheller J, Eriksson AL, Borén J, Hedner T, Ohlsson C, Härd T, Rose-John S, Jansson JO
Regul Pept 146(1-3):189-96
 
81
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J
Blood 111(3):1021-8
 
80
Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling.
Wei LH, Baumann H, Tracy E, Wang Y, Hutson A, Rose-John S, Henderson BW
Br J Cancer 97(11):1513-22
 
79
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
Koch M, May U, Kuhns S, Drechsler H, Adam N, Hattermann K, Wirtz S, Rose-John S, Scheller J
Biochem Biophys Res Commun 364(3):483-7
 
78
Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress.
Appenheimer MM, Girard RA, Chen Q, Wang WC, Bankert KC, Hardison J, Bain MD, Ridgley F, Sarcione EJ, Buitrago S, Kothlow S, Kaspers B, Robert J, Rose-John S, Baumann H, Evans SS
Eur J Immunol 37(10):2856-67
 
77
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C
J Immunol 179(4):2041-5
 
76
Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo.
Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA, O'Donnell VB
Am J Pathol 171(1):315-25Erratum in: Am J Pathol 171(3):1078
 
75
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J
Blood 110(6):1748-55
 
74
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF
Int Immunol 19(6):685-93
 
73
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.
Yeoh GC, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB
Hepatology 45(2):486-94
 
72
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP
Cancer Res 67(1):332-8
 
71
Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.
Chattopadhyay S, Tracy E, Liang P, Robledo O, Rose-John S, Baumann H
J Biol Chem 282(5):3014-26
 
70
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism.
Chen Q, Fisher DT, Clancy KA, Gauguet JM, Wang WC, Unger E, Rose-John S, von Andrian UH, Baumann H, Evans SS
Nat Immunol 7(12):1299-308
 
69
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.
Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grötzinger J
Biol Chem 387(9):1255-9
 
68
Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display.
Kovaleva M, Bussmeyer I, Rabe B, Grötzinger J, Sudarman E, Eichler J, Conrad U, Rose-John S, Scheller J
J Virol 80(17):8510-20
 
67
Sleep enhances IL-6 trans-signaling in humans.
Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA, Scheller J, Rose-John S, Born J
FASEB J 20(12):2174-6
 
66
gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes.
Tenhumberg S, Schuster B, Zhu L, Kovaleva M, Scheller J, Kallen KJ, Rose-John S
Biochem Biophys Res Commun 346(3):649-57
 
65
Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.
Lin M, Rose-John S, Grötzinger J, Conrad U, Scheller J
Biochem J 398(3):577-83
 
64
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice.
Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, Handa K, Tsuruta O, Funabashi H, Scheller J, Toyonaga A, Sata M
Gut 55(9):1263-9
 
63
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA
Arthritis Rheum 54(5):1662-72
 
62
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.
Stuhlmann-Laeisz C, Lang S, Chalaris A, Krzysztof P, Enge S, Eichler J, Klingmüller U, Samuel M, Ernst M, Rose-John S, Scheller J
Mol Biol Cell 17(7):2986-95
 
61
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
Watt MJ, Dzamko N, Thomas WG, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio MA, Steinberg GR
Nat Med 12(5):541-8
 
60
Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.
Oberg HH, Wesch D, Grüssel S, Rose-John S, Kabelitz D
Int Immunol 18(4):555-63
 
59
Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells.
Campard D, Vasse M, Rose-John S, Poyer F, Lamacz M, Vannier JP
Stem Cells 24(5):1302-14
 
58
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K
Mol Cell Biol 25(20):9040-53
 
57
Viral IL-6 blocks neutrophil infiltration during acute inflammation.
Fielding CA, McLoughlin RM, Colmont CS, Kovaleva M, Harris DA, Rose-John S, Topley N, Jones SA
J Immunol 175(6):4024-9
 
56
Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
Obreja O, Biasio W, Andratsch M, Lips KS, Rathee PK, Ludwig A, Rose-John S, Kress M
Brain 128(Pt 7):1634-41
 
55
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.
Klein C, Wüstefeld T, Assmus U, Roskams T, Rose-John S, Müller M, Manns MP, Ernst M, Trautwein C
J Clin Invest 115(4):860-9
 
54
Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro.
Hieronymus T, Gust TC, Kirsch RD, Jorgas T, Blendinger G, Goncharenko M, Supplitt K, Rose-John S, Müller AM, Zenke M
J Immunol 174(5):2552-62
 
53
Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.
Schroers A, Hecht O, Kallen KJ, Pachta M, Rose-John S, Grötzinger J
Protein Sci 14(3):783-90
 
52
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.
Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, Haddad el-B, Lehr HA, Schmitt E, Bopp T, Kallen KJ, Herz U, Schmitt S, Luft C, Hecht O, Hohlfeld JM, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S
J Clin Invest 115(5):1388Lehr, Hans A [added].
 
51
IL-6 signaling promotes tumor growth in colorectal cancer.
Becker C, Fantini MC, Wirtz S, Nikolaev A, Lehr HA, Galle PR, Rose-John S, Neurath MF
Cell Cycle 4(2):217-20
 
50
No inhibition of IL-27 signaling by soluble gp130
Scheller J, Schuster B, Hölscher C, Yoshimoto T, Rose-John S
Biochem Biophys Res Commun 326(4):724-8
 
49
Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1
Waetzig GH, Rosenstiel P, Arlt A, Till A, Bräutigam K, Schäfer H, Rose-John S, Seegert D, Schreiber S
FASEB J 19(1):91-3
 
48
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF
Immunity 21(4):491-501
 
47
Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling.
Curnow SJ, Scheel-Toellner D, Jenkinson W, Raza K, Durrani OM, Faint JM, Rauz S, Wloka K, Pilling D, Rose-John S, Buckley CD, Murray PI, Salmon M
J Immunol 173(8):5290-7
 
46
Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells.
Matthews VB, Rose-John S, Yeoh GC
Hepatology author reply 760
 
45
Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.
Scheller J, Kovaleva M, Rabe B, Eichler J, Kallen KJ, Rose-John S
J Immunol Methods 291(1-2):93-100
 
44
Maintenance of pluripotency in human embryonic stem cells is STAT3 independent.
Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo MT, Rose-John S, Hayek A
Stem Cells. 2004;22(4):522-30
 
43
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC, Bulfone-Paus S
J Biol Chem 286(11):9894
 
42
1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor.
Schwantner A, Dingley AJ, Ozbek S, Hecht O, Rose-John S, Grötzinger J
J Biomol NMR 29(3):407-8
 
41
Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons.
März P, Probst A, Lang S, Schwager M, Rose-John S, Otten U, Ozbek S
J Biol Chem 279(34):35542-50
 
40
The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis.
Wang XP, Schunck M, Kallen KJ, Neumann C, Trautwein C, Rose-John S, Proksch E
J Invest Dermatol 123(1):124-31
 
39
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A
J Immunol 172(10):6362-72
 
38
Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy.
Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J
J Biol Chem 279(1):571-6
 
37
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130
Nowell MA, Richards PJ, Horiuchi S, Yamamoto N, Rose-John S, Topley N, Williams AS, Jones SA
J Immunol 171(6):3202-9
 
36
Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction.
Fuchs M, Hilfiker A, Kaminski K, Hilfiker-Kleiner D, Guener Z, Klein G, Podewski E, Schieffer B, Rose-John S, Drexler H
FASEB J 17(14):2118-20
 
35
Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
J Clin Invest 112(4):598-607
 
34
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen KJ, Rose-John S
J Biol Chem 278(40):38829-39
 
33
Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines.
Aasland D, Schuster B, Grötzinger J, Rose-John S, Kallen KJ
Biochemistry 42(18):5244-52
 
32
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A
Blood 102(4):1186-95
 
31
Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling.
Ju XS, Hacker C, Madruga J, Kurz SM, Knespel S, Blendinger G, Rose-John S, Martin Z
Eur J Cell Biol 82(2):75-86
 
30
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.
Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, Rose-John S, Kallen KJ
J Biol Chem 278(11):9528-35
 
29
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane.
Schuster B, Meinert W, Rose-John S, Kallen KJ
FEBS Lett 538(1-3):113-6
 
28
Transcriptional profiling identifies Id2 function in dendritic cell development.
Hacker C, Kirsch RD, Ju XS, Hieronymus T, Gust TC, Kuhl C, Jorgas T, Kurz SM, Rose-John S, Yokota Y, Zenke M
Nat Immunol 4(4):380-6
 
27
Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth.
Lacroix S, Chang L, Rose-John S, Tuszynski MH
J Comp Neurol 454(3):213-28
 
26
Murine stromal cells producing hyper-interleukin-6 and Flt3 ligand support expansion of early human hematopoietic progenitor cells without need of exogenous growth factors.
Keller U, Götze KS, Duyster J, Schmidt B, Rose-John S, Peschel C
Leukemia 16(10):2122-8
 
25
Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12
Löhr HF, Pingel S, Böcher WO, Bernhard H, Herzog-Hauff S, Rose-John S, Galle PR
Clin Exp Immunol 130(1):107-14
 
24
The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons.
Sun Y, März P, Otten U, Ge J, Rose-John S
Biochem Biophys Res Commun 295(2):532-9
 
23
Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor.
März P, Ozbek S, Fischer M, Voltz N, Otten U, Rose-John S
Eur J Biochem 269(12):3023-31
 
22
Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells.
Klouche M, Brockmeyer N, Knabbe C, Rose-John S
AIDS 16(8):F9-18
 
21
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6
Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW
Stem Cells. 2002;20(2):119-38
 
20
The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex.
Aasland D, Oppmann B, Grötzinger J, Rose-John S, Kallen KJ
J Mol Biol 315(4):637-46
 
19
Humoral responses to melanoma vaccine, genetically modified with interleukin 6 and soluble interleukin 6 receptor.
Nawrocki S, Łaciak M, Izycki D, Gryska K, Wysocki PJ, Grabarczyk P, Karczewska A, Kaczmarek A, Murawa P, Malicki J, Rose-John S, Mackiewicz A
Adv Exp Med Biol. 2001;495:411-8
 
18
Coordination of interleukin-6 biology by membrane bound and soluble receptors.
Rose-John S
Adv Exp Med Biol. 2001;495:145-51
 
17
Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.
Böcher WO, Dekel B, Schwerin W, Geissler M, Hoffmann S, Rohwer A, Arditti F, Cooper A, Bernhard H, Berrebi A, Rose-John S, Shaul Y, Galle PR, Löhr HF, Reisner Y
Eur J Immunol 31(7):2071-9
 
16
gp130-stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells.
Götze KS, Keller U, Rose-John S, Peschel C
Exp Hematol 29(7):822-32
 
15
Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis B virus infection.
Heinz D, Peters M, Prange R, Gerken G, Rose-John S
J Viral Hepat 8(3):186-93
 
14
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA
Immunity 14(6):705-14
 
13
In vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130
Chow D, Ho J, Nguyen Pham TL, Rose-John S, Garcia KC
Biochemistry 40(25):7593-603
 
12
Hyper-IL-6 gene therapy reverses fulminant hepatic failure.
Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH
Mol Ther 3(5 Pt 1):683-7
 
11
A novel and rapid prediction assay for the effectiveness of IL-6 receptor specific antisense oligonucleotides by proliferation inhibition of an interleukin-6 dependent cell line.
Lia Varga V, Falus A, Pallinger E, Novák I, Fülöp KA, Toth S, Rose-John S
Cell Biol Int. 2001;25(3):253-6
 
10
The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells.
Ozbek S, Peters M, Breuhahn K, Mann A, Blessing M, Fischer M, Schirmacher P, Mackiewicz A, Rose-John S
Oncogene 20(8):972-9
 
9
Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.
Mann A, Breuhahn K, Schirmacher P, Wilhelmi A, Beyer C, Rosenau A, Ozbek S, Rose-John S, Blessing M
Cancer Res 61(5):2311-9
 
8
Structure of an extracellular gp130 cytokine receptor signaling complex.
Chow D, He X, Snow AL, Rose-John S, Garcia KC
Science 291(5511):2150-5
 
7
Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells.
Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ
Proc Natl Acad Sci U S A 98(4):1757-62
 
6
Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.
Althoff K, Müllberg J, Aasland D, Voltz N, Kallen K, Grötzinger J, Rose-John S
Biochem J 353(Pt 3):663-72
 
5
Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro.
Peters M, Solem F, Goldschmidt J, Schirmacher P, Rose-John S
Exp Hematol 29(2):146-55
 
4
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.
Jostock T, Müllberg J, Ozbek S, Atreya R, Blinn G, Voltz N, Fischer M, Neurath MF, Rose-John S
Eur J Biochem 268(1):160-7
 
3
Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration.
Peters M, Blinn G, Jostock T, Schirmacher P, Meyer zum Büschenfelde KH, Galle PR, Rose-John S
Gastroenterology 119(6):1663-71
 
2
Astrocytic alterations in interleukin-6/Soluble interleukin-6 receptor alpha double-transgenic mice.
Brunello AG, Weissenberger J, Kappeler A, Vallan C, Peters M, Rose-John S, Weis J
Am J Pathol 157(5):1485-93
 
1
Generation of tumor-reactive CTL against the tumor-associated antigen HER2 using retrovirally transduced dendritic cells derived from CD34+ hemopoietic progenitor cells.
Meyer zum Büschenfelde C, Nicklisch N, Rose-John S, Peschel C, Bernhard H
J Immunol 165(7):4133-40
 
 
 

Reviews

 
49
Interleukin-6: designing specific therapeutics for a complex cytokine.
Garbers C, Heink S, Korn T, Rose-John S.
Nat Rev Drug Discov 2018 Jun;17(6):395-412
 
48
Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis.
Bender L, Weidmann H, Rose-John S, Renné T, Long AT.
Front Immunol 8:1115.
 
47
Proteolytic steps within signaling cascades make these signaling pathways irreversible.
Rose-John S.
Biochim Biophys Acta 1864(11 Pt B):2057-2058. Editorial - no abstract available.
 
46
The shedding protease ADAM17: Physiology and pathophysiology.
Zunke F, Rose-John S.
Biochim Biophys Acta 1864(11 Pt B):2059-2070
 
45
The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation.
Rose-John S.
Clin Pharmacol Ther 102(4):591-598.
 
44
Interleukin-6 Family Cytokines.
Rose-John S.
Cold Spring Harb Perspect Biol 10(2)
 
43
The role of IL-6 in host defence against infections: immunobiology and clinical implications.
Rose-John S, Winthrop K, Calabrese L.
Nat Rev Rheumatol 13(7):399-409.
 
42
The role of interleukin-6 signaling in nervous tissue.
Rothaug M, Becker-Pauly C, Rose-John S.
Biochim Biophys Acta 1863(6 Pt A):1218-27.
 
41
The soluble interleukin-6 receptor and related proteins.
Rose-John S.
Best Pract Res Clin Endocrinol Metab 29(5):787-97.
 
40
"Family reunion"--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines.
Rose-John S, Scheller J, Schaper F.
Cytokine Growth Factor Rev 26(5):471-4.
 
39
Interleukin-6: Biology, signaling and strategies of blockade.
Schaper F, Rose-John S
Cytokine Growth Factor Rev 26(5):475-87. doi: 10.1016/j.cytogfr.2015.07.004. Review.
 
38
ADAM17, shedding, TACE as therapeutic targets.
Rose-John S
Pharmacol Res 71:19-22
 
37
The regenerative activity of interleukin-6
Galun E, Rose-John S
Methods Mol Biol. 982:59-77
 
36
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
Rose-John S
Int J Biol Sci. 8(9):1237-47
 
35
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Chalaris A, Schmidt-Arras D, Yamamoto K, Rose-John S
Dig Dis. 30(5):492-9
 
34
The interleukin 6 pathway and atherosclerosis.
Scheller J, Rose-John S
Lancet 380(9839):338
 
33
Plasticity and cross-talk of interleukin 6-type cytokines.
Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J
Cytokine Growth Factor Rev 23(3):85-97
 
32
Therapeutic blockade of interleukin-6 in chronic inflammatory disease.
Yamamoto K, Rose-John S
Clin Pharmacol Ther 91(4):574-6
 
31
Hitting a complex target: an update on interleukin-6 trans-signalling.
Waetzig GH, Rose-John S
Expert Opin Ther Targets 16(2):225-36
 
30
Interleukin-6 in sepsis and capillary leakage syndrome.
Krüttgen A, Rose-John S
J Interferon Cytokine Res 32(2):60-5
 
29
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.
Jones SA, Scheller J, Rose-John S
J Clin Invest 121(9):3375-83
 
28
ADAM17: a molecular switch to control inflammation and tissue regeneration.
Scheller J, Chalaris A, Garbers C, Rose-John S
Trends Immunol 32(8):380-7
 
27
The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S
Biochim Biophys Acta 1813(5):878-88
 
26
Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization.
Suthaus J, Adam N, Grötzinger J, Scheller J, Rose-John S
Eur J Cell Biol 90(6-7):495-504
 
25
The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.
Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J
Eur J Cell Biol 90(6-7):484-94
 
24
Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases?
Febbraio MA, Rose-John S, Pedersen BK
Clin Pharmacol Ther 87(4):396-8
 
23
Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application.
Floss DM, Schallau K, Rose-John S, Conrad U, Scheller J
Trends Biotechnol 28(1):37-45
 
22
Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration.
Drucker C, Gewiese J, Malchow S, Scheller J, Rose-John S
J Autoimmun 34(1):29-37
 
21
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Rose-John S, Mitsuyama K, Matsumoto S, Thaiss WM, Scheller J
Curr Pharm Des. 2009;15(18):2095-103
 
20
The IL-6/sIL-6R complex as a novel target for therapeutic approaches.
Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D
Expert Opin Ther Targets 11(5):613-24
 
19
Cytokines are a therapeutic target for the prevention of inflammation-induced cancers.
Rose-John S, Schooltink H
Recent Results Cancer Res. 2007;174:57-66
 
18
Designer cytokines for human haematopoietic progenitor cell expansion: impact for tissue regeneration.
Rose-John S
Handb Exp Pharmacol. 2006;(174):229-47
 
17
Interleukin-6 trans-signaling in inflammatory bowel disease.
Mitsuyama K, Sata M, Rose-John S
Cytokine Growth Factor Rev 17(6):451-61
 
16
Interleukin-6 and its receptor: from bench to bedside.
Scheller J, Rose-John S
Med Microbiol Immunol 195(4):173-83
 
15
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.
Rose-John S, Scheller J, Elson G, Jones SA
J Leukoc Biol 80(2):227-36
 
14
Interleukin-6 trans-signalling in chronic inflammation and cancer.
Scheller J, Ohnesorge N, Rose-John S
Scand J Immunol 63(5):321-9
 
13
IL-6 transsignaling: the in vivo consequences.
Jones SA, Richards PJ, Scheller J, Rose-John S
J Interferon Cytokine Res 25(5):241-53
 
12
Designing cytokine variants by phage-display.
Schooltink H, Rose-John S
Comb Chem High Throughput Screen 8(2):173-9
 
11
Virokines in the pathogenesis of cancer: focus on human herpesvirus 8
Klouche M, Carruba G, Castagnetta L, Rose-John S
Ann N Y Acad Sci 1028:329-39
 
10
IL-6 trans-signaling: the heat is on.
Rose-John S, Neurath MF
Immunity 20(1):2-4
 
9
CDP-870Celltech/Pfizer.
Rose-John S, Schooltink H
Curr Opin Investig Drugs 4(5):588-92
 
8
Interleukin-6 biology is coordinated by membrane bound and soluble receptors.
Rose-John S
Acta Biochim Pol. 2003;50(3):603-11
 
7
The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex.
Jones SA, Rose-John S
Biochim Biophys Acta 1592(3):251-63
 
6
Cytokines come of age.
Rose-John S
Biochim Biophys Acta 1592(3):213-4
 
5
GP130 stimulation and the maintenance of stem cells.
Rose-John S
Trends Biotechnol 20(10):417-9
 
4
Cytokines as therapeutic drugs.
Schooltink H, Rose-John S
J Interferon Cytokine Res 22(5):505-16
 
3
Signals regulating neurotrophin expression in glial cells.
Otten U, März P, Heese K, Hock C, Kunz D, Rose-John S
Prog Brain Res. 132:545-54
 
2
Cytokines and neurotrophins interact in normal and diseased states.
Otten U, März P, Heese K, Hock C, Kunz D, Rose-John S
Ann N Y Acad Sci. 2000;917:322-30
 
1
New perspectives on the design of cytokines and growth factors.
Kallen KJ, Grötzinger J, Rose-John S
Trends Biotechnol 18(11):455-61
 
 
Original Publications
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Letzte Änderung / Last change: Oktober 8, 2019