Univ. Prof. Dr. Stefan Rose-John

Stefan Rose-John
Stefan Rose-John
Molecular Biology of Cytokines
Research Areas
Structural aspects of cytokines and cytokine receptor complexes
Biochemistry and physiology of soluble cytokine receptors
Characterization of shedding enzymes
Role of cytokines in cellular differentiation
Molecular and physiological characterization of viral cytokines
Molecular and physiological characterization of matrix metalloproteinases


Hyper-IL-6: a highly active designer cytokine consisting of Interleukin-6 (IL-6) and soluble Interleukin-6 receptor (sIL-6R). Molecular model of the fusion protein consisting of IL-6 (gray) and sIL-6R (yellow) fused by a flexible peptide linker (green). A, B, C, and D denote the four helices of IL-6; D-II and D-III are the two cytokinebinding receptor domains of the soluble IL-6R used for the construction of the fusion protein. The fusion protein Hyper-IL-6 is 100-1000 times more active than the separate proteins IL-6 and sIL-6R. Hyper-IL-6 can be used to stimulate several types of target cells, which are not stimulated by IL-6 alone, since they do not express the membrane bound IL-6R. Such cells include embryonic stem cells, endothelial cells, hematopoietic progenitor cells, osteoclasts and neuronal cells.
Structure of hIL6