Banner

 

Univ. Prof. Dr. Paul Saftig

Paul Saftig
Paul Saftig
Home
Research
CV
Group
Publications
Contact
Molecular Cell Biology and Transgenic Research
 
News
News - Biochemisches Institut - Paul Saftig

News

1 newsitems found. Page 1 of 1.
Intracellular cholesterol transporter identified
In a new study we provide multiple lines of evidence that the lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) participates in lipid transport from lysosomes by transporting cholesterol (and possibly also other lipid species) through its luminal cavity to the lysosomal membrane.

Our experiments support a fundamental physiological role of LIMP-2 in lipid transport alongside the known NPC1 and NPC2 pathways. Our results may help direct the development of drugs that can enhance lipid recycling out of the lysosome and/or alleviate the negative consequences of lipidoses.

This study is a nice example of a successful collabporative effort with experiments performed in Canada (S. Grinstein), China (D. Neculai) and Europe (E.Ikonen, P. Saftig).

Suggested reading:

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D. (2019)
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Nat Commun.10(1):3521.


Show all items | Show topics

Latest Headlines

Intracellular cholesterol transporter identified
In a new study we provide multiple lines of...
read more >>>
 
 
 
Back to top
Meter odometer
Tumblr Counter