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PD Dr. Dirk Schmidt-Arras

Dirk Schmidt-Arras
Dirk Schmidt-Arras
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Inflammation and Cancer

Publications

Original Publications & Reviews

24
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice.
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich FT, Mittrücker HW, Rose-John S, Schmidt-Arras D.
Hepatology. 2017 Jan;65(1):89-103
 
23
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response.
Heim D, Gil-Ibanez I, Herden J, Parplys AC, Borgmann K, Schmidt-Arras D, Lohse AW, Rose-John S, Wege H.
Oncotarget. 2016 Aug 23;7(34):55639-55648
 
22
Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.
Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, Becker-Pauly C.
Biol Chem. 2016 Sep 1;397(9):857-69
 
21
A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis.
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zboda­kova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker JE, Saftig P, Schmidt-Arras D.
Oncotarget. 2016 Apr 5;7(14):17431-41
 
20
IL-6 pathway in the liver: From physiopathology to therapy.
Schmidt-Arras D, Rose-John S.
J Hepatol. 2016 Jun;64(6):1403-15. Review.
 
19
Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.
Cayla M, Rachidi N, Leclercq O, Schmidt-Arras D, Rosenqvist H, Wiese M, Späth GF.
PLoS Pathog. 2014 Sep 18;10(9):e1004347
 
18
Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.
Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A.
J Biol Chem. 2014 Jan 31;289(5):3080-93
 
17
Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G.
J Immunol. 2013 Dec 1;191(11):5574-82
 
16
Oncogenic deletion mutants of gp130 signal from intracellular compartments.
Schmidt-Arras D, Müller M, Stevanović M, Horn S, Schütt A, Bergmann J, Wilkens R, Lickert A, Rose-John S.
J Cell Sci. 2014 Jan 15;127(Pt 2):341-53
 
15
Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A.
Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367
 
14
gp130 activation is regulated by D2-D3 interdomain connectivity.
Schütt A, Zacharias M, Schneider N, Horn S, Grötzinger J, Rose-John S, Schmidt-Arras D.
Biochem J. 2013 Mar 15;450(3):487-96
 
13
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
Prox J, Willenbrock M, Weber S, Lehmann T, Schmidt-Arras D, Schwanbeck R, Saftig P, Schwake M.
Cell Mol Life Sci. 2012 Sep;69(17):2919-32
 
12
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Chalaris A, Schmidt-Arras D, Yamamoto K, Rose-John S.
Dig Dis. 2012;30(5):492-9
 
11
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.
Horjales S, Schmidt-Arras D, Limardo RR, Leclercq O, Obal G, Prina E, Turjanski AG, Späth GF, Buschiazzo A.
Structure. 2012 Oct 10;20(10):1649-60
 
10
The pro- and anti-inflammatory properties of the cytokine interleukin-6.
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S.
Biochim Biophys Acta. 2011 May;1813(5):878-88
 
9
Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani.
Schmidt-Arras D, Leclercq O, Gherardini PF, Helmer-Citterich M, Faigle W, Loew D, Späth GF.
J Proteomics. 2011 Aug 24;74(9):1644-51
 
8
Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.
Yau WL, Blisnick T, Taly JF, Helmer-Citterich M, Schiene-Fischer C, Leclercq O, Li J, Schmidt-Arras D, Morales MA, Notredame C, Romo D, Bastin P, Späth GF.
PLoS Negl Trop Dis. 2010 Jun 29;4(6):e729
 
7
Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes.
Choudhary C, Olsen JV, Brandts C, Cox J, Reddy PN, Böhmer FD, Gerke V, Schmidt-Arras DE, Berdel WE, Müller-Tidow C, Mann M, Serve H.
Mol Cell. 2009 Oct 23;36(2):326-39
 
6
Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality.
Schmidt-Arras D, Böhmer SA, Koch S, Müller JP, Blei L, Cornils H, Bauer R, Korasikha S, Thiede C, Böhmer FD.
Blood. 2009 Apr 9;113(15):3568-76
 
5
Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives.
Stuible M, Zhao L, Aubry I, Schmidt-Arras D, Böhmer FD, Li CJ, Tremblay ML.
Chembiochem. 2007 Jan 22;8(2):179-86
 
4
Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.
Schmidt-Arras DE, Böhmer A, Markova B, Choudhary C, Serve H, Böhmer FD.
Mol Cell Biol. 2005 May;25(9):3690-703
 
3
Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1.
Imhof D, Wieligmann K, Hampel K, Nothmann D, Zoda MS, Schmidt-Arras D, Zacharias M, Böhmer FD, Reissmann S.
J Med Chem. 2005 Mar 10;48(5):1528-39
 
2
Flt3 receptor tyrosine kinase as a drug target in leukemia.
Schmidt-Arras D, Schwäble J, Böhmer FD, Serve H.
Curr Pharm Des. 2004;10(16):1867-83. Review.
 
1
Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.
Burger R, Bakker F, Guenther A, Baum W, Schmidt-Arras D, Hideshima T, Tai YT, Shringarpure R, Catley L, Senaldi G, Gramatzki M, Anderson KC.
Br J Haematol. 2003 Dec;123(5):869-78
 
Original Publications Back to Top
Letzte Änderung / Last change: August 14, 2019