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PD Dr. Bernd Schröder

Bernd Schröder
Bernd Schröder
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Intramembrane Proteases and Novel Lysosomal Membrane Proteins

Publications

Original Publications & Reviews

37
Mentrup T, Loock AC, Fluhrer R, Schröder B. (2017)
Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?
Biochim Biophys Acta 1864(11 Pt B):2169-2182
 
36
Schneppenheim J, Loock AC, Hüttl S, Schweizer M, Lüllmann-Rauch R, Oberg HH, Arnold P, Lehmann CHK, Dudziak D, Kabelitz D, Lucius R, Lennon-Duménil AM, Saftig P, Schröder B. (2017)
The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.
J Immunol 199(1):172-185
 
35
Nguyen TL, Schneppenheim J, Rudnik S, Lüllmann-Rauch R, Bernreuther C, Hermans-Borgmeyer I, Glatzel M, Saftig P, Schröder B. (2017)
Functional characterization of the lysosomal membrane protein TMEM192 in mice.
Oncotarget 8(27):43635-43652
 
34
Mentrup T, Fluhrer R, Schröder B. (2017)
Latest emerging functions of SPP/SPPL intramembrane proteases.
Eur J Cell Biol 96(5):372-382
 
33
Klionsky DJ, Abdelmohsen K, …, Schröder B, …, Zughaier SM (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12, 1-222.
 
32
Schröder B, Saftig P. (2016)
Intramembrane Proteolysis within lysosomes.
Ageing Res Rev 32:51-64. Review
 
31
Schröder B. (2016)
The multifaceted roles of the invariant chain CD74 - More than just a chaperone.
Biochim Biophys Acta 1863(6 Pt A):1269-81. Review
 
30
Hüttl S, Helfrich F, Mentrup T, Held S, Fukumori A, Steiner H, Saftig P, Fluhrer R, Schröder B. (2016)
Substrate determinants of Signal peptide peptidase-like 2a (SPPL2a)-mediated Intramembrane Proteolysis of the Invariant chain CD74.
Biochem J 473(10):1405-22.
 
29
Hüttl S, Kläsener K, Schweizer M, Schneppenheim J, Oberg HH, Kabelitz D, Reth M, Saftig P, Schröder B. (2015)
Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells.
J Immunol 195(4):1548-63.
 
28
Mentrup T, Häsler R, Fluhrer R, Saftig P, Schröder B. (2015)
A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.
Traffic 16(8):871-92.
 
27
Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R. (2015)
Secretome analysis identifies novel signal Peptide peptidase-like 3 (sppl3) substrates and reveals a role of sppl3 in multiple Golgi glycosylation pathways.
Mol Cell Proteomics 14(6):1584-98.
 
26
Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R. (2014)
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.
EMBO J 17;33(24):2890-905
 
25
Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. (2014)
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
Nat Commun 5:4699.
 
24
Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, Schneppenheim R, Martin CL, Schröder B. (2014)
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells.
Biochem Biophys Res Commun 451(1):48-53.
 
23
Videm P, Gunasekaran D, Schröder B, Mayer B, Biniossek ML, Schilling O. (2014)
Automated peptide mapping and protein-topographical annotation of proteomics data.
BMC Bioinformatics 15:207.
 
22
Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B. (2014)
The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
Mol Cell Biol 34(8):1398-411
 
21
Kraft S, Jouvin MH, Kulkarni N, Kissing S, Morgan ES, Dvorak AM, Schröder B, Saftig P, Kinet JP. (2013)
The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.
J Immunol 191(6):2871-8.
 
20
Voss M, Schröder B, Fluhrer R. (2013)
Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.
Biochim Biophys Acta 1828(12):2828-39. Review.
 
19
Bronckers AL, Gueneli N, Lüllmann-Rauch R, Schneppenheim J, Moraru AP, Himmerkus N, Bervoets TJ, Fluhrer R, Everts V, Saftig P, Schröder B. (2013)
The intramembrane protease SPPL2A is critical for tooth enamel formation.
J Bone Miner Res 28(7):1622-30.
 
18
Schwake M, Schröder B, Saftig P. (2013)
Lysosomal membrane proteins and their central role in physiology.
Traffic 14(7):739-48
 
17
Schneppenheim J, Dressel R, Hüttl S, Lüllmann-Rauch R, Engelke M, Dittmann K, Wienands J, Eskelinen EL, Hermans-Borgmeyer I, Fluhrer R, Saftig P, Schröder B. (2013)
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.
J Exp Med 210(1):41-58
 
16
Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R. (2012)
Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).
J Biol Chem 287(52):43401-9.
 
15
Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P, Schröder B. (2011)
Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.
FEBS Lett 585(19):2951-7.
 
14
Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jézégou A, Reinheckel T, Hasilik A, Saftig P, Schröder B. (2011)
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
Biochem J 439(1):113-28.
 
13
Behnke J, Eskelinen EL, Saftig P, Schröder B. (2011)
Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers.
Biochem J 434(2):219-31.
 
12
Saftig P, Schröder B, Blanz J. (2010)
Lysosomal membrane proteins: life between acid and neutral conditions.
Biochem Soc Trans 38(6):1420-3.
 
11
Schröder BA, Wrocklage C, Hasilik A, Saftig P. (2010)
The proteome of lysosomes.
Proteomics 10(22):4053-76.
 
10
Schröder B, Saftig P. (2010)
Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP).
Biochem J 427(3):e1-3.
 
9
Schröder B, Wrocklage C, Hasilik A, Saftig P. (2010)
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane.
Biol Chem 391(6):695-704
 
8
Hasilik A, Wrocklage C, Schröder B. (2009)
Intracellular trafficking of lysosomal proteins and lysosomes.
Int J Clin Pharmacol Ther 47 Suppl 1:S18-33. Review.
 
7
Schieweck O, Damme M, Schröder B, Hasilik A, Schmidt B, Lübke T. (2009)
NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.
Biochem J 422(1):83-90.
 
6
Schröder J, Lüllmann-Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, Koch-Nolte F, Schröder B, Bleich M, Saftig P. (2009)
Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.
Mol Cell Biol 29(4):1083-94.
 
5
Beertsen W, Willenborg M, Everts V, Zirogianni A, Podschun R, Schröder B, Eskelinen EL, Saftig P. (2008)
Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice.
J Immunol 180(1):475-82.
 
4
Schröder B, Wrocklage C, Pan C, Jäger R, Kösters B, Schäfer H, Elsässer HP, Mann M, Hasilik A. (2007)
Integral and associated lysosomal membrane proteins.
Traffic 8(12):1676-86.
 
3
Schröder B, Elsässer HP, Schmidt B, Hasilik A. (2007)
Characterisation of lipofuscin-like lysosomal inclusion bodies from human placenta.
FEBS Lett 581(1):102-8.
 
2
Schröder B, Hasilik A. (2006)
A protocol for combined delipidation and subfractionation of membrane proteins using organic solvents.
Anal Biochem 357(1):144-6.
 
1
Melcher R, Hillebrand A, Bahr U, Schröder B, Karas M, Hasilik A. (2000)
Glycosylation-site-selective synthesis of N-acetyl-lactosamine repeats in bis-glycosylated human lysozyme.
Biochem J 348 Pt 3:507-15.
 
Original Publications
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