|Dr. Matthias Voss|
|Unit for Cytokine and Metalloproteinase Research|
|Matthias was recently recruited to and is currently in the process of setting up an independent
research group at the Institute of Biochemistry in Kiel. Until autumn 2018 he was a postdoctoral fellow at
Karolinska Institutet in Stockholm, Sweden, where his work focussed on cell biology and biochemistry of
novel genes implicated in primary immunodeficiencies and cancer predispositions. His stay in Sweden
was supported by fellowships and research grants from Swedish national but also international funding bodies. Before that
he conducted his PhD research in the lab of Christian Haass and Regina Fluhrer in Munich and working on
the intramembrane protease SPPL3.
As a main focus, the junior group will study the proteolytic shedding of glycosyltransferases and other glycan-modifying enzymes and thus aligns with the institute‘s and the CRC877‘s focus on proteolytic posttranslational modifications. Through their role in protein glycosylation, these enzymes are indispensable for secretory protein quality control and function. Even though their activity is foremost required in the ER and the Golgi network, it had been established decades ago that secretion of glycosyltransferases is a widespread phenomenon - but its physiological impact remained obscure. Given that most glycosyltransferases are single-pass membrane proteins, their secretion inevitably depends on proteolytic separation from their membrane anchors. My PhD research established SPPL3 as a major sheddase of Golgi glycosyltransferases. Building on this, the group’s research aims to systematically examine proteolytic processing of Golgi-resident glycan-modifying enzymes.In addition, in collaboration with my previous host lab at Karolinska Institutet and other institutions, a continuing interest lies in the cell biology and biochemistry of genes linked to primary immunodeficiencies and cancer predispositions. A notable example includes the twin tumour suppressors SAMD9 and SAMD9L, mutations in which have only recently emerged as cause of human hematologic malignancies and severe developmental defects.
|As a recently established research group, the voss lab will be growing further and we are thus eager to have motivated, gifted
and hard-working individuals – in particular students – join our team. If this applies to you and you are interested in our research,
don't hesitate to email Matthias to discuss project opportunities.
|Back to Top|
|Letzte Änderung / Last change: April 11, 2019|