Dr. Friederike Zunke

Athena Chalaris-Rissmann
Friederike Zunke
The Shedding Protease ADAM17


Original Publications

Original Publications
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.
Cuddy LK, Wani WY, Morella ML, Pitcairn C, Tsutsumi K, Fredriksen K, Justman CJ, Grammatopoulos TN, Belur NR, Zunke F, Subramanian A, Affaneh A, Lansbury PT Jr, Mazzulli JR.
Neuron. 2019 Dec 4;104(5):869-884.e11.
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
Cabron AS, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert JP, Pavlenko E, Schumacher N, Renné T, Taylor PR, Linder S, Rose-John S, Zunke F.
J Immunol. 2018 Nov 15;201(10):3106-3118
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.
J Exp Med. 2018 Apr 2;215(4):1205-1225
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.
Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR.
Neuron. 2018 Jan 3;97(1):92-107.e10
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D.
J Neurosci. 2016 Jul 20;36(29):7693-706
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.
Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M.
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3791-6
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.
Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D.
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1931-6
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
Blanz J, Zunke F, Markmann S, Damme M, Braulke T, Saftig P, Schwake M.
Traffic. 2015 Oct;16(10):1127-36
Calcium negatively regulates meprin β activity and attenuates substrate cleavage.
Arnold P, Schmidt F, Prox J, Zunke F, Pietrzik C, Lucius R, Becker-Pauly C.
FASEB J. 2015 Aug;29(8):3549-57
LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease.
Rothaug M, Stroobants S, Schweizer M, Peters J, Zunke F, Allerding M, D'Hooge R, Saftig P, Blanz J.
Acta Neuropathol Commun. 2015 Jan 31;3:6
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.
Peters J, Rittger A, Weisner R, Knabbe J, Zunke F, Rothaug M, Damme M, Berkovic SF, Blanz J, Saftig P, Schwake M.
Biochem Biophys Res Commun. 2015 Feb 13;457(3):334-40
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance. Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J.
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8
Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis.
Gaspar P, Kallemeijn WW, Strijland A, Scheij S, Van Eijk M, Aten J, Overkleeft HS, Balreira A, Zunke F, Schwake M, Sá Miranda C, Aerts JM.
J Lipid Res. 2014 Jan;55(1):138-45
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.
Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S.
Nature. 2013 Dec 5;504(7478):172-6
Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension.
Chadha PS, Zunke F, Zhu HL, Davis AJ, Jepps TA, Olesen SP, Cole WC, Moffatt JD, Greenwood IA.
Hypertension. 2012 Apr;59(4):877-84
Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.
Chadha PS, Zunke F, Davis AJ, Jepps TA, Linders JT, Schwake M, Towart R, Greenwood IA.
Br J Pharmacol. 2012 Jun;166(4):1377-87


α-Synuclein in Parkinson's disease: causal or bystander?
Riederer P, Berg D, Casadei N, Cheng F, Classen J, Dresel C, Jost W, Krüger R, Müller T, Reichmann H, Rieß O, Storch A, Strobel S, van Eimeren T, Völker HU, Winkler J, Winklhofer KF, Wüllner U, Zunke F, Monoranu CM.
J Neural Transm (Vienna). 2019 Jul;126(7):815-840. Review.
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation.
Pavlenko E, Cabron AS, Arnold P, Dobert JP, Rose-John S, Zunke F.
Int J Mol Sci. 2019 May 4;20(9). Review.
Modeling neuronopathic storage diseases with patient-derived culture systems.
Zunke F, Mazzulli JR.
Neurobiol Dis. 2019 Jul;127:147-162. Review.
The shedding protease ADAM17: Physiology and pathophysiology.
Zunke F, Rose-John S. (2017)
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2059-2070. Review
Original Publications Back to Top
Letzte Änderung / Last change: Januar 7, 2020